36期

最新文章

• Capturing the native structure of membrane proteins AI翻译
  作者：Liu, Hang; Tse, Chun Mong; Dang, Shangyu
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Membrane proteins play crucial roles in numerous biological processes and are important drug targets. However, structural studies of membrane proteins often rely on solubilization with detergents, which may not accurately reflect their native states in a cellular context. Additionally, identifying suitable detergents for individual membrane proteins can be a detailed and time-consuming process. Here, we developed a vesicle-based method that preserves the native lipid environment for subsequent...
• Dynamic spatial representation of self and others' actions in the macaque frontal cortex (vol 121, e2403445121, 2024) AI翻译
  作者：Ninomiya, Taihei
• A thermodynamic perspective on mammalian neural crest ingression AI翻译
  作者：Pasiliao, Clarissa C.; Thomas, Evan C.; Yung, Theodora; Zhu, Min; Tao, Hirotaka; Sun, Yu; Goyal, Sidhartha; Hopyan, Sevan
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto
  摘要：The ingression of neural crest cells from an ectodermal to a mesodermal layer is regulated by instructive, directional cues and potentially stochastic, biophysical parameters such as differential cell adhesion and tension heterogeneity.However, a cohesive framework in which to consider how various influences contribute to ingression remains elusive. Here, we observe the cell behaviors of the murine neural crest in three dimensions over time and apply a free energy framework to more wholly unde...
• Tumor-expressed GPNMB orchestrates Siglec-9+TAM polarization and EMT to promote metastasis in triple-negative breast cancer AI翻译
  作者：Cao, Thuy Linh Dang; Kawanishi, Kunio; Hashimoto, Sachie; Hengphasatporn, Kowit; Nagai-Okatani, Chiaki; Kimura, Takaharu; Abdelaziz, Mohammed; Shiratani, Rie; Poullikkas, Thanasis; Azmi, Nuriza Ulul; Baba, Masaki; Okita, Yukari; Watanabe, Yukihide; Bando, Hiroko; Yamazaki, Satoshi; Shigeta, Yasuteru; Kuno, Atsushi; Kato, Mitsuyasu
  作者单位：University of Tsukuba; Showa Medical University; University of Tsukuba; University of Tsukuba; National Institute of Advanced Industrial Science & Technology (AIST); University of Tsukuba; University of Tokyo; Egyptian Knowledge Bank (EKB); Sohag University; University of Tsukuba; Juntendo University; University of Tsukuba
  摘要：Metastasis remains the leading cause of cancer-related mortality, driven by complex interactions within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a pivotal role in metastatic progression, yet their molecular diversity and upstream regulators remain poorly defined. Glycoprotein nonmetastatic melanoma protein B (GPNMB), overexpressed in subsets of tumors including triple-negative breast cancer (TNBC), is implicated in epithelial-mesenchymal transition (EMT) and c...
• Collective behavior of flexicles AI翻译
  作者：Schonhofer, Philipp W. A.; Glotzer, Sharon C.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：In recent years the functionality of synthetic active microparticles has edged even closer to that of their biological counterparts. However, we still lack the understanding needed to recreate at the microscale key features of autonomous behavior exhibited by microorganisms or swarms of macroscopic robots. In this study, we propose a model for a three-dimensional deformable cellular composite particle consisting of self-propelled rod-shaped colloids confined within a flexible vesicle-represent...
• Origami frustration and its influence on energy landscapes of origami assemblies AI翻译
  作者：Zang, Shixi; Zhao, Tuo; Misseroni, Diego; Paulino, Glaucio H.
  作者单位：Princeton University; University of Trento; Princeton University
  摘要：Harnessing instabilities of multicomponent multistable structural assemblies can potentially lead to scalable and reversible functionalities, which can be enhanced by exploring frustration. For instance, standard Kresling origami cells exhibit nontunable intrinsic energy landscapes determined by their geometry and material properties, limiting their adaptability after fabrication. To overcome this limitation, we introduce frustration to enable fine-tuning of the energy landscape and resulting ...
• Migration shapes senescence in a long-lived bird AI翻译
  作者：Cayuela, Hugo; Roques, Sebastien; Arnaud, Antoine; Germain, Christophe; Bechet, Arnaud; Champagnon, Jocelyn
  作者单位：Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); VetAgro Sup; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier
  摘要：Each year, billions of animals migrate across the globe on diverse spatial and temporal scales. Migration behavior thus plays a fundamental role in the life cycle and Darwinian fitness of many organisms. While the influence of migration on early-life survival and reproduction is well documented, its effects on senescence (aging) in advanced age remain largely unexplored. Using a unique 44-y ring-resighting dataset from long-lived, partially migratory bird species, the Greater Flamingo (Phoenic...
• The RNA- binding protein TRIM71 is essential for hearing in humans and mice and times auditory sensory organ development AI翻译
  作者：Li, Xiao - Jun; Morgan, Charles; Duy, Phan Q.; Evsen, Lale; Hao, Le T.; Machavoine, Roxane; Belhous, Kahina; Ernest, Sylvain; Denoyelle, Francoise; Mignot, Cyril; Brioude, Frederic; Parodi, Marine; Li, Lin; Huang, He; Ponniah, Prathamesh T. Nadar; Kolanus, Waldemar; Kahle, Kristopher T.; Marlin, Sandrine; Doetzlhofer, Angelika
  作者单位：Johns Hopkins University; Xi'an Jiaotong University; Yale University; Yale University; Yale University; Yale University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Hopital Universitaire Saint-Louis - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Hopital Universitaire Armand-Trousseau - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne Universite; Hopital Universitaire Armand-Trousseau - APHP; University of Bonn; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Johns Hopkins University; University of Sydney; Kolling Institute of Medical Research
  摘要：The RNA-binding protein TRIM71 is essential for brain development, and recent genetic studies in humans have identified TRIM71 as a risk gene for congenital hydrocephal-us (CH). Here, we show that monoallelic missense mutations in TRIM71 are associated with hearing loss (HL) and inner ear aplasia in humans. Utilizing conditional Trim71 knockout mice carrying a CH and HL-associated mutation, we demonstrate that loss of TRIM71 function during early otic development (embryonic day 9 to 10) causes...
• William S. Sly (1932-2025): A compassionate pioneer in biochemical genetics AI翻译
  作者：Sands, Mark S.; Grubb, Jeffrey H.; Vogler, Carole A.; Waheed, Abdul; Montano, Adriana M.
  作者单位：Washington University (WUSTL); Saint Louis University; Saint Louis University; Saint Louis University
  摘要：William S. Sly, MD (1932-2025) was a biochemical geneticist who received his medical degree from Saint Louis University. He received additional training at the NIH with several members of the National Academy of Science and Nobel Prize winner Marshall Nirenberg. He is best known for discovering mucopolysaccharidosis type VII and developing a Food and Drug Administration-approved treatment for it. He served in several long-term leadership roles and won many accolades, including the Passano Foun...
• Pdgf mediates a transient regeneration-activated cell state in planarian tissue regeneration AI翻译
  作者：Xu, Hao; Li, Yucong; Yang, Ling; Li, Nan; Lei, Kai
  作者单位：Zhejiang University; Westlake University; Westlake Laboratory; Westlake University; Fudan University
  摘要：The role of induced gene expression is crucial for tissue regeneration. The transient regenerative cellular state that discriminates between missing-tissue and non-missing-tissue injuries remains to be fully elucidated. In this study, we identified a homolog of Platelet-Derived Growth Factor (PDGF), named pdgf-like (pdgfl), in the planarian Schmidtea mediterranea. This gene exhibits inducible expression following missing-tissue injury in a back-and-forth manner between myosin+ muscular cells a...