36期

最新文章

• Fatty acid 2-hydroxylase facilitates rotavirus uncoating and endosomal escape AI翻译
  作者：Li, Enkai; Zang, Ruochen; Kawagishi, Takahiro; Zhang, Wei; Iyer, Kruthika; Hou, Gaopeng; Zeng, Qiru; Meganck, Rita M.; Ross, Susan R.; Wang, Xin; Su, Xiong; Ding, Siyuan
  作者单位：Washington University (WUSTL); Shandong University; University of Osaka; Washington University (WUSTL); University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Hainan University; Hainan University; Soochow University - China
  摘要：Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped double- stranded RNA viruses and the leading cause of severe dehydrating diarrhea in infants and young children. We identified fatty acid 2- hydroxylase (encoded by FA2H) in the fatty acid 2- hydroxylation pathway as a proviral gene that supports RV infection. Genetic ablation of FA2H interfered wi...
• AhR signaling in skin-resident CD207+cells is involved in UV-B-induced amelioration of neuroinflammation AI翻译
  作者：Mykicki, Nadine; Eble, Johannes A.; Weighardt, Heike; Gonnelli, Elena; Schneeweiss, Maria; Esser, Charlotte; Weishaupt, Carsten; Rezaei, Maryam; Foerster, Irmgard; Schwab, Nicholas; Wiendl, Heinz; Clausen, Bjoern E.; Meuth, Sven G.; Loser, Karin
  作者单位：Carl von Ossietzky Universitat Oldenburg; University of Munster; University of Bonn; University of Munster; Leibniz Association; Leibniz Institut fur Umweltmedizinische Forschung (IUF); University of Munster; University of Munster; University of Freiburg; Johannes Gutenberg University of Mainz; Heinrich Heine University Dusseldorf
  摘要：Environmental stimuli, including the exposure to ultraviolet (UV)-B light, are known to play a role in the modulation of immune-mediated mechanisms in multiple sclerosis (MS). In experimental autoimmune encephalomyelitis (EAE), we have shown that UV-B irradiation ameliorates disease outcome by regulatory T cells (Treg) expansion. Moreover, the UV-B-mediated induction of Treg numbers was also observed in MS. The aryl hydrocarbon receptor (AhR) can be activated by environmental factors including...
• 12/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation AI翻译
  作者：Thomas, Christopher P.; Tyrrell, Victoria J.; Burston, James J.; Johnson, Sam R. C.; Aldrovandi, Maceler; Alvarez-Jarreta, Jorge; Inglis, Rossa; Leonard, Adam; Fice, Lydia; Costales, Jeremie; Vidal-Puig, Antonio; Protty, Majd; Guy, Carol; Andrews, Robert; Szomolay, Barbara; Cossins, Ben C.; Figueras, Ana Cardus; Carobbio, Stefania; Jones, Simon A.; O'Donnell, Valerie B.
  作者单位：Cardiff University; Cardiff University; Cardiff University; Prince Felipe Research Center; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge
  摘要：12/15-lipoxygenase (12/15-LOX, Alox15) generates bioactive oxygenated lipids during inflammation, however its homeostatic role(s) in normal healing are unclear. Here, the role of 12/15-LOX in resolving skin wounds was elucidated, focusing on how its lipids act together in physiologically relevant amounts. In mice, wounding caused acute appearance of 12/15-LOX-expressing macrophages and stem cells, coupled to early generation of similar to 12 monohydroxy-oxylipins and enzymatically oxidized pho...
• Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state AI翻译
  作者：Zhang, Jingwei; Zhang, Jingwen; Han, Longfei; Wu, Shiyi; Li, Jie; Eaton, Elinor Ng; Yuan, Bingbing; Reinhardt, Ferenc; Li, Hao; Strasser, Patrick C.; Das, Sunny; Donahera, Joana Liu; Khalila, Md Imtiaz; Jiang, Haiping; Deuschel, Alexander; Lin, Danni; Sebastiany, Carolin; Maranga, Mariana; Shubitidze, Salome; Liu, Xiaofei; Lambert, Arthur W.; Zhang, Yun; Liu, Yana; Sui, Lufei; Elmiligy, Sarah; Pozza, Umberto; Gunsay, Rauf; Mishra, Ranjan; Velarde, Jose; Iyer, Sonia; Henra, Whitney S.; Weiskopf, Kipp; Fen, Guihai; Oni, Tobiloba E.; Watnick, Randolph S.; Li, Xin; Weinberg, Robert A.
  作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy of Sciences; Beijing Institute for Stem Cell & Regenerative Medicine; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Nankai University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Chinese Academy of Medical Sciences - Peking Union Medical College; Cancer Institute & Hospital - CAMS; Peking Union Medical College; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; University of Bergen; University of Bergen; Haukeland University Hospital; Massachusetts Institute of Technology (MIT)
  摘要：The awakening of dormant disseminated cancer cells appears to be responsible for the clinical relapses of patients whose primary tumors have been successfully cured months and even years earlier. In the present study, we demonstrate that dormant breast cancer cells lodged in the lungs reside in a highly mesenchymal, nonproliferative phenotypic state. The awakening of these cells is not triggered by a cancer peutic agent bleomycin effectively awakens dormant cancer cells, providing useful model...
• Surrogate optimization of variational quantum circuits AI翻译
  作者：Gustafson, Erik J.; Tiihonen, Juha; Chamaki, Diana; Sorourifar, Farshud; Mullinax, J. Wayne; Li, Andy C. Y.; Maciejewski, Filip B.; Sawaya, Nicolas P. D.; Krogel, Jaron T.; Neira, David E. Bernal; Tubman, Norm M.
  作者单位：National Aeronautics & Space Administration (NASA); NASA Ames Research Center; Universities Space Research Association (USRA); University of Jyvaskyla; Columbia University; University System of Ohio; Ohio State University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; United States Department of Energy (DOE); University of Chicago; Fermi National Accelerator Laboratory; United States Department of Energy (DOE); Oak Ridge National Laboratory; Purdue University System; Purdue University; National Aeronautics & Space Administration (NASA); NASA Ames Research Center
  摘要：Variational quantum eigensolvers are touted as a near-term algorithm capable of impacting many applications. However, the potential has not yet been realized, with few claims of quantum advantage and high resource estimates, especially due to the need for optimization in the presence of noise. Finding algorithms and methods to improve convergence is important to accelerate the capabilities of near-term hardware for variational quantum eigensolver or more broad applications of hybrid methods in...
• Founders predict trait evolution and population performance after evolutionary rescue in the red flour beetle AI翻译
  作者：Kumar, Vrinda Ravi; Buddh, Shyamsunder; Singhal, Shivansh; Prakash, Arun; Agashe, Deepa
  作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences; Michigan State University
  摘要：Evolutionary rescue helps populations survive environmental change, but the phenotypic and demographic factors associated with rescue dynamics and its long-term effects remain unclear. We experimentally evolved 10 wild-collected populations of flour beetles from across India in a suboptimal corn resource for 70 generations (>5 y), collecting >10,000 population census points book-ended by measurements of fitness-related traits for 30 experimental lines. Despite clear ancestral trait differences...
• Therapeutic restoration of mitochondria-endoplasmic reticulum cross talk for osteoarthritis AI翻译
  作者：Hou, Mingzhuang; Ma, Yifan; Deng, Yaoge; Wu, Yubin; Zhu, Yanrun; Liu, Yang; Li, Xiaoping; Yu, Lili; He, Zirui; Wang, Yifan; Dong, Shiyan; Xia, Xiaowei; Yu, Jianfeng; Yu, Chenqi; Kang, Kang; Lu, Yingjie; Sun, Lili; Kim, Betty Y. S.; Yuan, Yuan; Zhang, Yijian; Jiang, Wen; Zhu, Xuesong
  作者单位：Soochow University - China; Soochow University - China; University of Texas System; UTMD Anderson Cancer Center; University of Macau; East China University of Science & Technology; East China University of Science & Technology; University of Texas System; UTMD Anderson Cancer Center; Nanjing Medical University
  摘要：Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear. Here, we show that impaired mitochondrial function and disrupted cartilage matrix metabolism due to...
• 8,000 years of wild and domestic animal body size data reveal long- term synchrony and recent divergence due to intensified human impact AI翻译
  作者：Mureau, Cyprien; d'Oliveira, Lea; Peyron, Odile; Blaise, Emilie; Renaud, Audrey; Balcarcel, Ana; Jeanjean, Marine; Bonhomme, Vincent; Bouby, Laurent; Ros, Jerome; Evin, Allowen
  作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Universite Paul-Valery; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS)
  摘要：The long-term evolution of domestic mammal body size in Western Europe since the Early Neolithic is mainly attributed to human selection. However, the relative influence of environmental and anthropogenic factors in animal body size evolution, and the coevolution of wild and domestic species remain poorly understood. In the Northwestern Mediterranean, abundant archaeozoological data from well-contextualized sites and reliable paleoenvironmental reconstructions provide a unique opportunity to e...
• Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria AI翻译
  作者：Mendana, Alfonso; Santos-Merino, Maria; Gutierrez-Lanza, Raquel; Dominguez-Quintero, Marina; Medina-Mendez, Juan Manuel; Gonzalez-Guerra, Ana; Campa, Victor; Baez, Miguel; Ducos-Galand, Magaly; Lopez-Igual, Rocio; Volke, Daniel C.; Gugger, Muriel; Nikel, Pablo I.; Mazel, Didier; de la Cruz, Fernando; Fernandez-Lopez, Raul
  作者单位：Michigan State University; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC - Instituto de Bioquimica Vegetal y Fotosintesis (IBVF); Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Cantabria; CSIC - Instituto de Biomedicina y Biotecnologia de Cantabria (IBBTEC); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Technical University of Denmark; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris
  摘要：Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to different environments remains poorly understood. Here, we subjected the cyanobacterium Synechococcus elongatus PCC 7942 to a long-term evolution experiment under high light, high temperature, and elevated CO2 levels. After 1,200 generations, we obtained a strain exhibiting a 600% increase in growth rate. Whole-genome sequencing revealed three mutati...
• Rethinking early- life pathogen exposure: Lessons from a natural experiment controlling hookworms AI翻译
  作者：Schofield, Heather
  作者单位：Cornell University