-
作者：Sullivan, Patrick F.; Dial, Roman J.; Cooper, David J.; Diamond, Charles; Tino, Christopher J.; Gregory, Daniel D.; Wong, Russell E.; Lyons, Timothy W.
作者单位：University of Alaska System; University of Alaska Anchorage; Alaska Pacific University; University of California System; University of California Riverside; University of Toronto
摘要：The streams of Alaska's Brooks Range lie within a vast (similar to 14M ha) tract of protected wilderness and have long supported both resident and anadromous fish. However, dozens of historically clear streams have recently turned orange and turbid. Thawing permafrost is thought to have exposed sulfide minerals to weathering, delivering iron and other potentially toxic metals to aquatic ecosystems. Here, we report stream water metal concentrations throughout the federally designated Wild and S...
-
作者：Goutte, Sandra; Boissinot, Stephane
作者单位：New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi
摘要：Color polymorphism can influence the evolutionary fate of cryptic species because it increases populations' chances of survival in heterogenous or variable environments. Yet, little is known about the molecular and evolutionary mechanisms underlying the persistence of cryptic color polymorphisms, or the impact these polymorphisms have on the macroevolutionary dynamics of lineages. Here, we examine the evolutionary history of the most widespread cryptic color polymorphism in anurans, involving ...
-
作者：Shen, Fan; Li, Linjie; Yang, Dongchun; Tang, Zhexiao; Zhang, Lu; Liu, Kefang; Hou, Wenzhe; Lu, Zhuozhuang; Fang, Jing - Yuan; Qi, Jianxun; Zhao, Xin; Gao, George F.
作者单位：Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Institute of Process Engineering, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Shanghai Jiao Tong University; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention
摘要：In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate the dynamic modulation of binding strength between elongated bacterial cells and host cells remain poorly understood. Fusobacterium nucleatum (F. nucleatum) utilizes the surface adhesin CbpF to interact with the highly expressed host receptors CEACAM1 and CEACAM5 on cancer cells to facilitate tumor ...
-
作者：Yanai, Shogo; Sasaki, Junko; Lee-Okada, Hyeon-Cheol; Takahashi, Fumiya; Kikuchi, Yuto; Morioka, Shin; Yamamoto, Toshiyoshi; Yuguchi, Katsuya; Oikawa, Miko; Kajiho, Hiroaki; Baba, Takashi; Yokoyama, Chikako; Morohashi, Ken-Ichirou; Suzuki, Akira; Yokomizo, Takehiko; Sasaki, Takehiko
作者单位：Juntendo University; Kyushu University; Kyushu University; Kurume University; Kobe University
摘要：Adrenal lipomas are benign tumors containing ectopic adipose tissue in the adrenal gland, an organ that normally lacks both adipocytes and their progenitors. The origin of this ectopic fat remains enigmatic, and the absence of a genetic animal model has key signaling lipid that regulates cellular growth and differentiation, is tightly regulated by the lipid phosphatases PTEN (phosphatase and tensin homolog) and SHIP2 (SH2- containing inositol phosphatase 2). Here, we demonstrate that simultane...
-
作者：Childs, Marissa L.; Lyberger, Kelsey; Harris, Mallory J.; Burke, Marshall; Mordecai, Erin A.
作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard University; Stanford University; Arizona State University; University System of Maryland; University of Maryland College Park; Stanford University; Stanford University; National Bureau of Economic Research
摘要：Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas. We found a nonlinear relationship between temperature and dengue incidence with the largest impact of 11 to...
-
作者：Dhiman, Shikha; Vleugels, Marle E. J.; Post, Richard A. J.; Crippa, Martina; Cardellini, Annalisa; de Korver, Esmee; Su, Lu; Palmans, Anja R. A.; Pavan, Giovanni M.; van der Hofstad, Remco W.; Albertazzi, Lorenzo; Meijer, E. W.
作者单位：Eindhoven University of Technology; Eindhoven University of Technology; Johannes Gutenberg University of Mainz; Erasmus University Rotterdam; Erasmus MC; Polytechnic University of Turin; Leiden University - Excl LUMC; Leiden University; Eindhoven University of Technology; University of New South Wales Sydney; University of New South Wales Sydney
摘要：Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes,...
-
作者：Kaelin Jr, William G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute
摘要：Up to 10 to 20% of the proteome contains regions with much lower amino acid diversity than would be expected by chance. This year's Lasker Basic Science Award is given to Steven McKnight and Dirk G & ouml;rlich for their pioneering work on such low- complexity domains (LCDs). They showed, using a variety of elegant approaches, that such LCDs can form homotypic and heterotypic interactions that lead to reversible phase separations in cells. These phase separations, which in the laboratory manif...
-
作者：Turuban, Regis; Noselli, Giovanni; Beran, Alfred; DeSimone, Antonio
作者单位：Scuola Superiore Sant'Anna; International School for Advanced Studies (SISSA); Istituto Nazionale di Oceanografia e di Geofisica Sperimentale
摘要：Aquatic microorganisms typically inhabit a heterogeneous resource landscape, composed of localized and transient patches. To effectively exploit these resources, they have evolved a wide range of feeding strategies that combine chemotactic motility with active feeding flows. However, there is a notable lack of experimental studies that examine how these active flows shape resource fields to optimize feeding. In particular, the suspected cooperative hydrodynamics provided by groups of cells rem...
-
作者：Zhang, Jiazhi; Yu, Qin; Tian, Jiazhuang; Yang, Shanglu; Zuo, Xunwei; Li, Ying; Chen, Nailu; Rong, Yonghua; Ritchie, Robert O.; Lu, Jian
作者单位：Chinese Academy of Sciences; Shanghai Institute of Optics & Fine Mechanics, CAS; University of California System; University of California Berkeley; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; City University of Hong Kong; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong
摘要：Low-cost yet high-performance structural materials have been invariantly sought for modern engineering applications. However, due to the localized stress concentration induced by a high Peierls-Nabarro stress and limited dislocation mobility, increasing material strength usually comes at the expense of ductility and toughness, resulting in a trade-off between strength-ductility/strength-toughness. Here, we report an anomalous phenomenon of dislocation absorption at the crack front, which is un...
-
作者：Dong, Zhufeng; Yin, Tieyin; Deng, Zhiqin; Zou, Hang; Kuang, Lei; Wang, Yang; Shi, Wen; Han, Mengwei; Zhu, Siqing; Wang, Zheng; Hu, Xiaoye; Wang, Yazhou Z.
作者单位：Chongqing University; Chongqing University
摘要：Engineering functional exosomes represents a cutting-edge approach in biomedicine, holding the promise to transform targeted therapy. However, challenges such as achieving consistent modification and scalability have limited their wider adoption. Herein, we introduce a universal and effective strategy for engineering multifunctional exosomes through cell fusion. The hybrid-cell-derived exosomes could combine the functional properties of both parental cells and be readily produced by passaging....
