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作者：Ramarao, Malavika; Garcia-Gradilla, Victor; Unlu, Mehmet Burcin; Davis, Ronald W.; Durmus, Naside Gozde
作者单位：Stanford University; Stanford University; Universidad Nacional Autonoma de Mexico; Ozyegin University; Ozyegin University; Stanford University; Stanford University; Stanford University
摘要：The biophysical properties of single cells are crucial for understanding cellular function and behavior in biology and medicine. However, precise manipulation of cells in 3-D microfluidic environments remains challenging, particularly for heterogeneous populations. Here, we present Electro-LEV, a unique platform integrating electromagnetic and magnetic levitation principles for dynamic 3-D control of cell position during separation. We demonstrated that small current adjustments in electromagn...
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作者：Bar-Oz, Guy; Avni, Gideon
作者单位：University of Haifa
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作者：Bayless, Adam M.; Song, Lijiang; Sorbello, Mitchell; Ogden, Sam C.; Todd, Tyler S.; Flint, Alice; Maruta, Natsumi; Tulu, Jedidiah; Drenichev, Mikhail; Ntoukakis, Vardis; Ve, Thomas; Mobli, Mehdi; Wan, Li; Liu, Qingli; Dangl, Jeffery L.; Kobe, Bostjan; Grant, Murray; Nishimura, Marc T.
作者单位：Colorado State University System; Colorado State University Fort Collins; University of Warwick; University of Queensland; University of Queensland; University of Warwick; Russian Academy of Sciences; Engelhardt Institute of Molecular Biology, RAS; Griffith University; Griffith University - Gold Coast Campus; University of Queensland; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Syngenta; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Howard Hughes Medical Institute; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：The TIR (Toll/interleukin-1 receptor) domain is an ancient protein module that functions in immune and cell death responses across the Tree of Life. TIR domains encoded by plants and prokaryotes function as enzymes to produce diverse small molecule immune signals. Plant genomes can encode hundreds of TIR-domain containing proteins-many of which confer important agricultural disease resistance as TIR-NLR (nucleotide-binding, leucine-rich repeat) immune receptors. Despite their importance, how n...
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作者：Boutet, Marie-Astrid; Mattiola, Irene; Silva-Gomes, Rita; Nerviani, Alessandra; Sironi, Marina; Ghirardi, Giulia Maria; Troilo, Alessia; Gianoli, Stefano; Rivellese, Felice; Cubuk, Cankut; Goldmann, Katriona; Putignano, Anna Rita; Di Silvestre, Dario; Lomagno, Andrea; Borroni, Elena Monica; Sobacchi, Cristina; Lewis, Myles J.; Bottazzi, Barbara; Locati, Massimo; Mantovani, Alberto; Pitzalis, Costantino
作者单位：University of London; Queen Mary University London; University of London; Queen Mary University London; Nantes Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Universidade do Minho; University of Milan; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Consiglio Nazionale delle Ricerche (CNR); Istituto di Tecnologie Biomediche (ITB-CNR); Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); Humanitas University
摘要：MS4A4A belongs to the MS4A tetraspan protein superfamily and is selectively expressed by the monocyte-macrophage lineage. In this study, we aimed to evaluate the role of MS4A4A+ macrophages in rheumatoid arthritis (RA) pathogenesis and response to treatment. RNA sequencing and immunohistochemistry of synovial samples from either early treatment-na & iuml;ve or active chronic RA patients showed that MS4A4A expression positively correlated with synovial inflammation. Synovial macrophages from pa...
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作者：Ghosh, Sayak; Ikeda, Matthias S.; Chakraborty, Anzumaan R.; Worasaran, Thanapat; Theuss, Florian; Peralta, Luciano B.; Lozano, P. M.; Kim, Jong-Woo; Thompson, P. J.; Ryan, Philip J.; Ye, Linda; Kapitulnik, Aharon; Kivelson, Steven A.; Ramshaw, B. J.; Fernandes, Rafael M.; Fisher, Ian R.
作者单位：Stanford University; Stanford University; University of Minnesota System; University of Minnesota Twin Cities; Cornell University; Universidad de los Andes (Colombia); United States Department of Energy (DOE); Argonne National Laboratory; University of Liverpool; Stanford University; Canadian Institute for Advanced Research (CIFAR); University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：The iron-based high-Tc superconductors (SCs) exhibit rich phase diagrams with intertwined phases, including magnetism, nematicity, and superconductivity. The superconducting Tc in many of these materials is maximized in the regime of strong nematic fluctuations, making the role of nematicity in influencing the superconductivity a topic of intense research. Here, we use the AC elastocaloric effect (ECE) to map out the phase diagram of Ba(Fe1-xCox)2As2 near optimal doping. The ECE signature at T...
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作者：Li, Siyu; Lee, Byunguk; Lao, Yichong; Lertwiriyapiti, Sirawit; Huang, Xuhui; Wang, Tina
作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Improving the Calvin-Benson-Bassham cycle enzyme Ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) has the potential to increase crop productivity. However, the selectivity of the chaperones mediating Rubisco assembly in vascular plants toward their cognate Rubisco presents a substantive roadblock to both Rubisco protein engineering and transgenic expression of heterologous Rubisco orthologs, both of which necessitate changes to the Rubisco sequence. Here, we ask whether a plant Rubisc...
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作者：Espinoza, Ana P. Verduzco; Na, Na; Campanati, Loraine; Ngo, Priscilla; Baldwin, Kristin K.; Cline, Hollis T.
作者单位：Scripps Research Institute; Columbia University
摘要：Microglia regulate neuronal circuit plasticity. Disrupting their homeostatic function has detrimental effects on neuronal circuit health. Neuroinflammation contributes to the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), with several microglial activation genes linked to increased risk for these conditions. Inflammatory microglia alter neuronal excitability, inducing metabolic strain. Interestingly, expression of APOE4, the strongest genetic risk fact...
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作者：Tian, Tim Y. Y.; Wasteneys, Geoffrey O.; Macdonald, Colin B.; Cytrynbaum, Eric N.
作者单位：University of British Columbia; University of British Columbia
摘要：The self-organization of cortical microtubule (MT) arrays within plant cells is an emergent phenomenon with important consequences for the synthesis of the cell wall, cell shape, and subsequently the structure of plants. Mathematical modeling and experiments have elucidated the underlying processes involved. There has been recent interest in the influence of geometric cues on array orientation, be it direct (cell shape) or indirect (tension in the membrane). However, the mechanical influence o...
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作者：Zhu, Haojie; Cai, Xinlei; Zhu, Dianhui; Kang, Feiyu; Peng, Lu; Zhi, Chunyi; Yang, Cheng
作者单位：Tsinghua University; Tsinghua Shenzhen International Graduate School; Huazhong University of Science & Technology; Tsinghua University; Tsinghua Shenzhen International Graduate School; University of Hong Kong; University of Hong Kong; City University of Hong Kong
摘要：Aqueous sodium-ion batteries (ASIBs) are gaining attention for their inherent safety and the use of abundant sodium resources. Bismuth (Bi) anode, with its high theoretical capacity and low cost, enhances the performance and competitiveness ofASIBs in energy storage applications. However, as a conversion-type material, Bi inevitably undergoes dramatic volume changes during cycling, limiting the structural stability and calendar life of the electrode. Herein, we present a Bi-carbon composite el...
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作者：Bian, Ke; Gruber, Charley C.; Byers, Emine; Leclerc, Paul; Hemann, Michael T.; Walker, Graham C.
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：The mutagenic translesion synthesis (TLS) pathway, which is critically dependent on REV1's ability to recruit inserter TLS polymerases and the POLE extender polymerase, enables cancer cells to bypass DNA lesions while introducing mutations that likely contribute to the development of chemotherapy resistance and secondary malignancies. Targeting this pathway represents a promising therapeutic strategy. Here, we demonstrate that the expression of the C-terminal domain (CTD) of human REV1, a ca. ...
