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作者：Zhang, Yan; Son, Hyeonwi; Shannonhouse, John; Gomez, Ruben; Kim, Eungyung; Ai, Chih - Hsuan; Chung, Man - Kyo; Platisa, Jelena; Pieribone, Vincent A.; Kim, Yu Shin
作者单位：University System of Maryland; University of Maryland Baltimore; Yale University; The John B Pierce Laboratory, Inc; Yale University; Yale University; University of Texas System; University of Texas at San Antonio; University of Alabama System; University of Alabama Birmingham
摘要：In vivo voltage imaging is a powerful tool for monitoring action potentials and dynamic electrical events in heterogeneous sensory neurons enabling the deciphering of rapid somatosensory information processing. Virus-driven expression of genetically encoded voltage indicator (GEVI) suffers from inconsistent expression levels and offers a limited time window for optimal voltage imaging. Here, we generated and characterized a knock-in mouse line with Pirt-driven expression of Marina, a positivel...
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作者：Arrowood, Anthony; Frazier, Jackson; Ciccotti, Matteo; Sanoja, Gabriel E.
作者单位：University of Texas System; University of Texas Austin; Sorbonne Universite; Universite PSL; Centre National de la Recherche Scientifique (CNRS); Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); CNRS - Institute of Chemistry (INC)
摘要：Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture behavior of these materials remains a significant challenge, owing to the difficulty of quantifying the respective contributions from viscoelasticity and damage to energy dissipation ahead of cracks. This work aims to address this challenge by labeling a series of polymer networks with fluorogenic mec...
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作者：Casiulis, Mathias; Arbel, Eden; van Waes, Charlotte; Lahini, Yoav; Martiniani, Stefano; Oppenheimer, Naomi; Zion, Matan Yah Ben
作者单位：New York University; New York University; Tel Aviv University; Radboud University Nijmegen; New York University
摘要：We present a geometric design rule for size-controlled clustering of self-propelled particles. We show that active particles that tend to rotate under an external force have an intrinsic, signed parameter with units of curvature which we call curvity, that can be derived from first principles. Experiments with robots and numerical simulations show that properties of individual robots (radius and curvity) control pair cohesion in a binary system, and the stability of flocking and self-limiting ...
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作者：Di Cesare, Giuseppe; Koush, Yury; Zeidman, Peter; Sciutti, Alessandra; Friston, Karl; Rizzolatti, Giacomo
作者单位：University of Parma; Istituto Italiano di Tecnologia - IIT; Skolkovo Institute of Science & Technology; University of London; University College London; Consiglio Nazionale delle Ricerche (CNR)
摘要：Typically, people perform actions in a valenced-positive or negative-way, depending on their attitudes or desires. These forms of action are named vitality forms (VFs). While it is well established that action goals are mediated by a parieto-frontal network, less is known about the processing of VFs. Recent fMRI studies suggest that the insula (INS)-and its connections with the parieto-frontal circuit-plays a crucial role in VFs processing. However, a key question remains: How does our interna...
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作者：Yang, Mengye; White, Melissa A.; Findlay, Geoffrey D.; Vignogna, Ryan C.; Apger-McGlaughon, Jennifer; Clark, Nathan L.; Choi, Jae Young; Fromme, J. Christopher; Wolfner, Mariana F.
作者单位：Cornell University; College of the Holy Cross; Cornell University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Kansas; Cornell University
摘要：Ovulation is an intricate process that is essential for reproductive success. In Drosophila melanogaster, ovulation increases after mating. This increase is initiated by the male seminal fluid protein ovulin and is executed by female pathways, including octopamine (OA) neuronal signaling. Despite OA signaling's central role in ovulation regulation, the broader molecular landscape underlying female control of ovulation remains poorly understood. Here, using ovulin as a probe, we performed evolu...
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作者：Liao, Mengyu; Ye, Zhisheng; Zhao, Yumeng; Nan, Jiaying; Liu, Yuming; Yao, Xueming; Yang, Tianjing; Guo, Ju; Jin, Xin; Zhang, Hong; You, Caiyun; Xu, Heping; Yu, Jinguo; Chen, Yupeng; Wang, Xiaohong; Yan, Hua
作者单位：Tianjin Medical University; Tianjin Medical University; Nankai University; Harbin Medical University; Queens University Belfast; Tianjin Medical University; Tianjin Medical University
摘要：Ocular fibrosis, a severe consequence of excessive retinal wound healing, can lead to vision loss following retinal injury. Proliferative vitreoretinopathy (PVR), a common form of ocular fibrosis, is a major cause of blindness, characterized by the formation of extensive fibrous proliferative membranes. Understanding the cellular origins of PVR-associated fibroblasts (PAFs) is essential to decipher the mechanisms of ocular wound healing. In this study, we combined single-cell transcriptomics w...
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作者：Linos, Elizabeth; Lasky-Fink, Jessica; Dorie, Vincent; Rothstein, Jesse
作者单位：Harvard University; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Behaviorally informed nudges are widely used in government outreach but are often seen as too modest to address poverty at scale. In four field experiments over 2 y (n = 542,804 low-income households), we test whether more proactive communication, varying message framing, and more precise targeting can boost take-up of tax-based benefits in California above and beyond traditional light-touch approaches. Our interventions focused on extremely vulnerable households, most with no prior-year earni...
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作者：McCarthy, Clara I.; Ma, Z. Zack; Monteggia, Lisa M.; Kavalali, Ege T.
作者单位：Vanderbilt University; Vanderbilt University
摘要：Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects. We show tha...
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作者：Racette, Molly
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：There are significant differences in the critical care of neonatal and pediatric patients as compared with adults. These patients have their own reference intervals, which can change rapidly as they develop. The rate of this change will be unique to the individual and the veterinary literature provides few concrete recommendations. As recommendations are applied to each patient, close reassessment is needed to further refine their treatment plan. Attention to how neonatal and pediatric physiol...
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作者：Videbaek, Thomas E.; Hayakawa, Daichi; Hagan, Michael F.; Grason, Gregory M.; Fraden, Seth; Rogers, W. Benjamin
作者单位：Brandeis University; University of Massachusetts System; University of Massachusetts Amherst
摘要：Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structurally complex, dynamic, and functional assemblies necessitates going beyond the design of the structure itself, to the measurement and control of the local flexibility of the intersubunit connections and its impact on the collective mechanics of the entire assembly. In this study, we demonstrate a me...
