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作者：Sharma, Mira; DiVincenzo, David P.
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作者：Liao, Mengyu; Ye, Zhisheng; Zhao, Yumeng; Nan, Jiaying; Liu, Yuming; Yao, Xueming; Yang, Tianjing; Guo, Ju; Jin, Xin; Zhang, Hong; You, Caiyun; Xu, Heping; Yu, Jinguo; Chen, Yupeng; Wang, Xiaohong; Yan, Hua
作者单位：Tianjin Medical University; Tianjin Medical University; Nankai University; Harbin Medical University; Queens University Belfast; Tianjin Medical University; Tianjin Medical University
摘要：Ocular fibrosis, a severe consequence of excessive retinal wound healing, can lead to vision loss following retinal injury. Proliferative vitreoretinopathy (PVR), a common form of ocular fibrosis, is a major cause of blindness, characterized by the formation of extensive fibrous proliferative membranes. Understanding the cellular origins of PVR-associated fibroblasts (PAFs) is essential to decipher the mechanisms of ocular wound healing. In this study, we combined single-cell transcriptomics w...
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作者：Linos, Elizabeth; Lasky-Fink, Jessica; Dorie, Vincent; Rothstein, Jesse
作者单位：Harvard University; University of California System; University of California Berkeley; University of California System; University of California Berkeley
摘要：Behaviorally informed nudges are widely used in government outreach but are often seen as too modest to address poverty at scale. In four field experiments over 2 y (n = 542,804 low-income households), we test whether more proactive communication, varying message framing, and more precise targeting can boost take-up of tax-based benefits in California above and beyond traditional light-touch approaches. Our interventions focused on extremely vulnerable households, most with no prior-year earni...
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作者：McCarthy, Clara I.; Ma, Z. Zack; Monteggia, Lisa M.; Kavalali, Ege T.
作者单位：Vanderbilt University; Vanderbilt University
摘要：Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects. We show tha...
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作者：Racette, Molly
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：There are significant differences in the critical care of neonatal and pediatric patients as compared with adults. These patients have their own reference intervals, which can change rapidly as they develop. The rate of this change will be unique to the individual and the veterinary literature provides few concrete recommendations. As recommendations are applied to each patient, close reassessment is needed to further refine their treatment plan. Attention to how neonatal and pediatric physiol...
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作者：[Anonymous]
摘要：Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structurally complex, dynamic, and functional assemblies necessitates going beyond the design of the structure itself, to the measurement and control of the local flexibility of the intersubunit connections and its impact on the collective mechanics of the entire assembly. In this study, we demonstrate a me...
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作者：Capua-Shenkar, Jenny; Kaestner, Antonia; Rechav, Katya; Brumfeld, Vlad; Ashiri, Ifat Kaplan -; Varsano, Neta; Avinoam, Ori; Speter, Chen; Halak, Moshe; Kruth, Howard; Addadi, Lia
作者单位：Weizmann Institute of Science; University of Michigan System; University of Michigan; Weizmann Institute of Science; Weizmann Institute of Science; Tel Aviv University; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
摘要：We applied micro- computed tomography, high- resolution cryo- scanning electron microscopy (SEM) combined with cathodoluminescence, and cryo- focused ion beam Milling- SEM to perform three- dimensional imaging of human atherosclerotic tissues with tens of nanometers resolution, under hydrated, near- native conditions with minimal sample processing. The same technology was applied to cultured macrophages exposed to cholesterol crystals, and the observations made on the macrophages were compared...
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作者：Wang, Ying-Han; Fu, Chong-Lei; Chen, Lin-Bo; Zhang, Chu-Yi; Chen, Jian- Shan; Zhang, Qiao-Ming; Liang, Yirui; Yang, Rui-Lan; Li, Yu; Zhang, Ya-Ni; Han, Yi-Nuo; Yuan, Zhen-Liang; Chen, Yi-Ni; Li, Haimei; Pan, Yanmeng; Hu, Shaohua; Li, Ming; Cao, Li-Ping; Yao, Jun
作者单位：Tsinghua University; Shandong First Medical University & Shandong Academy of Medical Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Guangzhou Medical University; Zhejiang University
摘要：Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduced expression in BDII patient plasma, which correlated with the disease severity.Using induced pluripotent stem cell (iPSC) models of sporadic and familial BDII patients, we found that Serinc2 expressi...
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作者：Madangopal, Rajtarun; Zhao, Yuan; Heins, Conor; Zhou, Jingfeng; Liang, Bo; Barbera, Giovanni; Lam, Ka Chun; Komer, Lauren E.; Webera, Sophia J.; Thompson, Drake J.; Gera, Yugantar; Pham, Diana Q.; Savell, Katherine E.; Warren, Brandon L.; Caprioli, Daniele; Venniro, Marco; Bossert, Jennifer M.; Ramsey, Leslie A.; Jedema, Hank P.; Schoenbaum, Geoffrey; Lin, Da-Ting; Shaham, Yavin; Pereira, Francisco; Hope, Bruce T.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); Sapienza University Rome; IRCCS Santa Lucia; IRCCS Santa Lucia; University System of Maryland; University of Maryland Baltimore
摘要：Learning when to initiate or withhold actions is essential for survival, requiring the inte-gration of past experiences with new information to adapt to changing environments. The prelimbic cortex (PL) plays a central role in this process, with a stable PL neuronal population (ensemble) recruited during operant reward learning to encode response execution. However, it is unknown how this established reward-learning ensemble adapts to changing reward contingencies, such as reward omission durin...
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作者：Arrowood, Anthony; Frazier, Jackson; Ciccotti, Matteo; Sanoja, Gabriel E.
作者单位：University of Texas System; University of Texas Austin; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Sorbonne Universite
摘要：Many soft, tough materials have emerged in recent years, paving the way for advances in wearable electronics, soft robotics, and flexible displays. However, understanding the interfacial fracture behavior of these materials remains a significant challenge, owing to the difficulty of quantifying the respective contributions from viscoelasticity and damage to energy dissipation ahead of cracks. This work aims to address this challenge by labeling a series of polymer networks with fluorogenic mec...
