37期

最新文章

• A genetically encoded nanobody sensor reveals conformational diversity in β- arrestins orchestrated by distinct seven transmembrane receptors AI翻译
  作者：Sarma, Parishmita; Markova, Vendula Nagy; Dalal, Annu; Mishra, Sudha; Zaidi, Nashrah; Tiwari, Divyanshu; Yadav, Manish K.; Roy, Nabarun; Mahajan, Gargi; Miclea, Paul; Lazar, Josef; Shukla, Arun K.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Charles University Prague; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Charles University Prague
  摘要：Agonist-induced interaction of G protein-coupled receptors (GPCRs) with beta- arrestins (beta arrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-beta arr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of beta arr-mediated functional outcomes. Considering the key contribution of conformati...
• Characterizing population-level changes in human behavior during the COVID-19 pandemic in the United States AI翻译
  作者：Urmi, Tamanna; Pant, Binod; Dewey, George; Quintana-Mathe, Alexi; Lang, Iris; Druckman, James; Ognyanova, Katherine; Baum, Matthew; Perlis, Roy; Riedl, Christoph; Lazer, David; Santillana, Mauricio
  作者单位：Northeastern University; Northeastern University; Harvard University; University of Rochester; Harvard University; Harvard University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Northeastern University; Northeastern University; Harvard University; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：The transmission of communicable diseases in human populations is known to be modulated by behavioral patterns. However, detailed characterizations of how population-level behaviors change over time during multiple disease outbreaks and spatial resolutions are still not widely available. We used data from 431,211 survey responses collected in the United States, between April 2020 and June 2022, to provide a description of how human behaviors fluctuated during the first 2 y of the COVID-19 pand...
• The redox rhythm gates immune- induced cell death distinctly from the genetic clock AI翻译
  作者：Karapetyan, Sargis; Mwimba, Musoki; Chen, Tianyuan; Yao, Zhujun; Dong, Xinnian
  作者单位：Duke University; Howard Hughes Medical Institute; Duke University
  摘要：Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth's day-night cycles and regulate responses to environmental signals to gain competitive advantage. While divergent genetic clocks have been studied extensively in bacteria, fungi, plants, and animals, an ancient conserved circadian redox rhythm has been recently reported. However, its biological function and physiological outputs remain elusive. Here, we uncovered the coexistence of redox and genetic r...
• In vivo Pirt- Marina voltage sensor imaging detects primary sensory neuron-specific voltage dynamics and neuronal plasticity changes AI翻译
  作者：Zhang, Yan; Son, Hyeonwi; Shannonhouse, John; Gomez, Ruben; Kim, Eungyung; Ai, Chih - Hsuan; Chung, Man - Kyo; Platisa, Jelena; Pieribone, Vincent A.; Kim, Yu Shin
  作者单位：University System of Maryland; University of Maryland Baltimore; Yale University; The John B Pierce Laboratory, Inc; Yale University; Yale University; University of Texas System; University of Texas at San Antonio; University of Alabama System; University of Alabama Birmingham
  摘要：In vivo voltage imaging is a powerful tool for monitoring action potentials and dynamic electrical events in heterogeneous sensory neurons enabling the deciphering of rapid somatosensory information processing. Virus-driven expression of genetically encoded voltage indicator (GEVI) suffers from inconsistent expression levels and offers a limited time window for optimal voltage imaging. Here, we generated and characterized a knock-in mouse line with Pirt-driven expression of Marina, a positivel...
• Relationship dynamics and behavioral adaptations in the control of the 2022 mpox epidemic AI翻译
  作者：Hvid, Ulrik; Simonsen, Lone; Frisch, Morten; Sneppen, Kim
  作者单位：University of Copenhagen; Niels Bohr Institute; Roskilde University; Statens Serum Institut; Aalborg University
  摘要：We analyzed the patterns of transmission in the 2022 clade IIb mpox epidemic as it unfolded in the European population of men who have sex with men (MSM). We developed an agent-based model that simulates sexual pair formation, incorporating both brief and longer-term sexual relationships. The model implements survey data on the sexual behavior of MSM and accounts for the highly heterogeneous nature of the sexual contact network within this community. When simulating the mpox epidemic, the mode...
• Replication stress-induced nuclear hypertrophy alters chromatin topology and impacts cancer cell fitness AI翻译
  作者：Kim, Changgon; Hong, Semyeong; Ma, Soo Hyeon; Lee, Joochan; So, Hee; Kim, Jun Young; Shin, Eunbie; Lee, Kippeum; Choi, Sohee; Park, Juyeon; Park, YongKeun; Kim, You-Me; Kim, Ji Hun; Kim, Joon
  作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea University; Korea University Medicine (KU Medicine); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Microscopic examination of biopsy tissues remains essential for cancer diagnosis, despite advancements in sequencing technologies. Alterations in nuclear size or the nuclear- to- cytoplasmic ratio are hallmark features of cancer cells and often correlate with disease progression. However, the mechanisms underlying nuclear size abnormalities and their impact on tumor progression remain unclear. In this study, we demonstrate that nuclear hypertrophy occurs in response to enhanced DNA replication...
• Structure of a polymorphic repeat at the CACNA1C locus AI翻译
  作者：Moya, Raquel; Wang, Xiaohan; Tsien, Richard W.; Maurano, Matthew T.
  作者单位：New York University; New York University; New York University; New York University
  摘要：Genetic variation within intron 3 of the CACNA1C calcium channel gene is associated with schizophrenia and other neuropsychiatric disorders, but analysis of the causal variants and their effect is complicated by a nearby variable- number tandem repeat (VNTR). Here, we explored the structure and population variability of the CACNA1C intron 3 VNTR using 155 long- read genome assemblies from 78 diverse individuals. Based on sequence differences among repeat units, we clustered individual sequence...
• Evolution of cross- tolerance to metals in yeast AI翻译
  作者：Bazzicalupo, Anna L.; Kahn, Penelope C.; Ao, Eully; Campbell, Joel; Otto, Sarah P.
  作者单位：University of British Columbia; University of British Columbia; Royal Botanic Gardens, Kew
  摘要：Organisms often face multiple selective pressures simultaneously (e.g., mine tailings with multiple heavy metal contaminants), yet we know little about when adaptation to one stressor provides cross-tolerance or cross-intolerance to other stressors. To explore the potential for cross-tolerance, we adapted Saccharomyces cerevisiae to high concentrations of six single metals in a short-term evolutionary rescue experiment. We then measured cross-tolerance of each metal-adapted line to the other f...
• Motivational trade- offs and modulation of nociception in bumblebees (Vol 119, e2205821119, 2022) AI翻译
  作者：Gibbons, Matilda; Versace, Elisabetta; Crump, Andrew; Baran, Bartosz; Chittka, Lars
• DNA polymerase α- primase can function as a translesion DNA polymerase AI翻译
  作者：Mayle, Ryan; Georgescu, Roxana; O'Donnell, Michael E.
  作者单位：Howard Hughes Medical Institute; Rockefeller University
  摘要：Replication of cellular chromosomes requires a primase to generate short RNA primers to initiate genomic replication. While bacterial and archaeal primase generate short RNA primers, the eukaryotic primase, Polc-primase, contains both RNA primase and DNA polymerase (Pol) subunits that function together to form a >20 base hybrid RNA-DNA primer. Interestingly, the DNA Pol1 subunit of Polc lacks a 3'- 5' proofreading exonuclease, contrary to the high-fidelity normally associated with DNA replicat...