37期

最新文章

• Critical exponents of the spin-glass transition in a field at zero temperature AI翻译
  作者：Angelini, Maria Chiara; Palazzi, Saverio; Parisi, Giorgio; Rizzo, Tommaso
  作者单位：Sapienza University Rome; Istituto Nazionale di Fisica Nucleare (INFN); Beihang University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR); Consiglio Nazionale delle Ricerche (CNR); Istituto dei Sistemi Complessi (ISC-CNR)
  摘要：We analyze the spin-glass transition in a field in finite dimension D below the upper critical dimension directly at zero temperature using a recently introduced perturbative loop expansion around the Bethe lattice solution. The expansion is generated by the so-called M-layer construction, and it has 1/M as the associated small parameter. Computing analytically and numerically these nonstandard diagrams at first order in the 1/M expansion, we construct an e-expansion around the upper critical ...
• ApoD mediates age- associated increase in vulnerability to influenza virus infection AI翻译
  作者：Jiang, Zhimin; Pan, Wenliang; Chen, Yu; Zhou, Dongliang; Ren, Shuning; Tong, Qi; Liu, Litao; Sun, Honglei; Sun, Yipeng; Bi, Yuhai; Wang, Dayan; Lu, Lu; Pu, Juan; Chang, Kin - Chow; Liu, Jinhua
  作者单位：China Agricultural University; Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Center for Disease Control & Prevention; National Institute for Viral Disease Control & Prevention, Chinese Center for Disease Control & Prevention; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; University of Edinburgh; University of Nottingham
  摘要：Influenza A virus (IAV) infection causes significantly greater morbidity and mortality in the elderly population, but the molecular mechanisms in the aging process responsible for severe infection remain unclear. In this study, we found that increased severity in IAV infection and reduced innate immune response correlated with extensive mitophagy in senescent human cells and in the lung of aged mice. Apolipoprotein D (ApoD) was identified as strongly elevated in the lungs and sera of aged huma...
• Emergent depth-mechanosensing of epithelial collectives regulates cell clustering and dispersal on layered matrices AI翻译
  作者：Yu, Hongsheng; Pathak, Amit
  作者单位：Washington University (WUSTL)
  摘要：During wound healing, tumor growth, and organ formation, epithelial cells migrate and cluster in layered tissue environments. Although cellular mechanosensing of adhered extracellular matrices is now well recognized, it is unclear how deeply cells sense through distant matrix layers. Since single cells can mechanosense stiff basal surfaces through soft hydrogels of <10 mu m thickness, here we ask whether cellular collectives can perform such depth-mechanosensing through thicker matrix layers. ...
• Excitatory glycine receptors control ventral hippocampus synaptic plasticity and anxiety-related behaviors AI翻译
  作者：Pizzamiglio, Lara; Morice, Elise; Cardoso, Cecile; Bossi, Simon; Mailhes-Hamon, Caroline; von Heimendahl, Moritz; Girardeau, Gabrielle; Paoletti, Pierre
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
  摘要：Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory neurotransmitter. Unlike conventional GluN1/GluN2 NMDARs, the distribution and role of eGlyRs remain poorly understood. Here, we show that eGlyRs are highly enriched in the ventral hippocampus (VH) and confer distinct properties on this brain region. eGlyRs di...
• The Lasker∼Koshland Special Achievement Award in Medical Science awarded to Lucy Shapiro AI翻译
  作者：Vosshall, Leslie B.
  作者单位：Howard Hughes Medical Institute; Rockefeller University; Rockefeller University
  摘要：Scientists can contribute to society in numerous ways. Some scientists discover new biological principles and found entirely new fields. Some scientists are inspiring mentors and create the next generation of inclusive lab leaders. Some scientists are entrepreneurs who develop clinically effective therapeutics. Some scientists are trusted advisors to government and pharmaceutical companies. Some scientists are visionary institutional leaders who build new departments. From this menu of activit...
• The coherence of US cities AI翻译
  作者：Daniotti, Simone; Hartog, Matte; Neffke, Frank
  作者单位：Technische Universitat Wien; Utrecht University; Harvard University
  摘要：Diversified economies are critical for cities to sustain their growth and development, but they are also costly because diversification often requires expanding a city's capability base. We analyze how cities manage this trade-off by measuring the coherence of the economic activities they support, defined as the technological distance between randomly sampled productive units in a city. We use this framework to study how the US urban system developed over almost two centuries, from 1850 to tod...
• Wild bats hunt insects faster under lit conditions by integrating acoustic and visual information AI翻译
  作者：Stidsholt, Laura; Zebele, Mara; Scholz, Carolin; Voigt, Christian C.
  作者单位：Leibniz Institut fur Zoo und Wildtierforschung; Aarhus University; University of Potsdam
  摘要：Animals can improve their decision-making abilities by integrating information from multiple senses, which is especially beneficial when living in fluctuating environments. However, understanding how wild predators may use multimodal sensing when hunting prey in split-second interactions remains largely unexplored. As nocturnal hunters, bats rely on echolocation to navigate and to locate evasive prey, yet they have retained functional vision, despite the associated costs. We therefore hypothes...
• Sorting nexin 3 promotes ischemic retinopathy through RIP1-and RIP3-mediated myeloid cell necroptosis and mitochondrial fission AI翻译
  作者：Wang, Jiaojiao; Zhou, Chunhong; Zhuang, Kai; Zou, Jiami; Qiu, Wanlu; Jin, Mei; Ye, Weile; Yang, Pinglian; Zheng, Zhihua; Zhou, Qing; Huang, Zunnan; Wang, Yuanxiang; Liu, Peiqing; Lu, Jing; Huo, Yuqing; Liu, Zhiping
  作者单位：Jinan University; Guangdong Medical University; Guangdong Medical University; Jinan University; Sun Yat Sen University; Sun Yat Sen University; Baylor College of Medicine
  摘要：Proliferative retinopathy is a leading cause of irreversible blindness in humans; however, the molecular mechanisms behind the immune cell-mediated retinal angiogenesis remain poorly elucidated. Here, using single-cell RNA sequencing in an oxygen-induced retinopathy (OIR) model, we identified an enrichment of sorting nexin (SNX)-related pathways, with SNX3, a member of the SNX family that is involved in endosomal sorting and trafficking, being significantly upregulated in the myeloid cell subp...
• Is Nav1.8-specific inhibition the only path? Preferential Nav blockers offer a compelling alternative AI翻译
  作者：Xiang, Bingbing; Deng, Chaoyi; Yang, Han; Zhang, Wensheng
  作者单位：Sichuan University; Sichuan University
• Disentanglement of prosodic meaning: Toward a framework for the analysis of nonverbal information in speech AI翻译
  作者：Biron, Tirza; Barboy, Moshe; Ben-Artzy, Eran; Golubchik, Alona; Marmor, Yanir; Marron, Assaf; Szekely, Smadar; Winter, Yaron; Harel, David
  作者单位：Weizmann Institute of Science
  摘要：We propose a theoretical framework and a cost-effective automated method for the interpretation of prosodic messages (e.g., chunking of information, emphasis, conversation action, emotion). At the core of the proposal is a hierarchy of layered prosodic messages that co-occur within the same intonation unit (0.5 to 2 s long). Motivated by this hierarchy, a procedure for the differential detection of three such co-occurring nonverbal messages is then described. In way of implementation, we produ...