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作者：Blazanin, Michael; Vasen, Eli; Jolis, Celia Vilaro; An, William; Turner, Paul E.
作者单位：Yale University; Yale University; Yale University; University of Barcelona; Yale University
摘要：A frequent goal of phage biology is to quantify how well a phage kills a population of host bacteria. Unfortunately, traditional methods to quantify phage success can be time-consuming, limiting the throughput of experiments. Here, we use theory to show how the effects of phages on their hosts can be quantified using bacterial population dynamics measured in a high-throughput microplate reader (automated spectrophotometer). We use mathematical models to simulate bacterial population dynamics w...
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作者：Cohen, Karly E.; Coates, Michael I.; Fraser, Gareth J.
作者单位：State University System of Florida; University of Florida; University of Washington; University of Chicago
摘要：Chimaeras (Holocephali) are an understudied group of mostly deep-ocean cartilaginous fishes (Chondrichthyes) with unique characteristics that distinguish them from their distant relatives, sharks, skates, and rays. Unlike sharks, chimaeras lack scales and do not have serially replacing rows of serrated teeth crowned with enameloid. Instead, they possess a fused dentition of dentine tooth plates. Additionally, male chimaeras develop an articulated cartilaginous facial appendage, the tenaculum, ...
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作者：Chen, Xiaochao; Bezodis, William; Gonzalez-Suarez, Pablo; Knitlhoffer, Vanda; Goldson, Andrew; Lister, Ashleigh; Macaulay, Iain; Penfield, Steven
作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Centre; Xianghu Laboratory; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Earlham Institute
摘要：How or whether organisms can inherit parental adaptations to the prevailing environment is a major topic in biology. In plants, seed traits such as size, yield, and dormancy are all affected by the environment during reproduction, but whether developing progeny sense temperature within the fruit or whether seasonal climate information is inherited intergenerationally from the parents remains unclear. In this study, we use intergenerational single- nucleus omics to understand the mechanisms und...
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作者：Meyer, Bettina; Arata, Javier A.; Atkinson, Angus; Bahlburg, Dominik; Bernard, Kim; Cardenas, Cesar A.; Grant, Susie M.; Hill, Simeon L.; Huppe, Lukas; Ichii, Taro; Kawaguchi, So; Krafft, Bjorn A.; Labrousse, Sara; Maschette, Dale; Pinones, Andrea; Reiss, Christian; Siebenhuner, Bernd; Sylvester, Zephyr; Ziegler, Philippe
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Carl von Ossietzky Universitat Oldenburg; Carl von Ossietzky Universitat Oldenburg; Oregon State University; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Antarctic Survey; University of Wurzburg; Australian Antarctic Division; University of Tasmania; University of Tasmania; Institute of Marine Research - Norway; Institut de Recherche pour le Developpement (IRD); Museum National d'Histoire Naturelle (MNHN); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); Universite Paris Saclay; Institut Polytechnique de Paris; CNRS - National Institute for Earth Sciences & Astronomy (INSU); Ecole Polytechnique; Universidad Austral de Chile; Universidad de Concepcion; Carl von Ossietzky Universitat Oldenburg; Nelson Mandela University; University of Colorado System; University of Colorado Boulder
摘要：Antarctic krill (Euphausiasuperba) is the central prey species in the Southern Ocean food web, supporting the largest and fastest-growing fishery in the region, managed by the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR). Climate change is threatening krill populations and their predators, while current catch limits do not take into account climate variability or krill population dynamics. In 2024, CCAMLR was unable to renew its spatial catch limits, highlighti...
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作者：Childs, Marissa L.; Lyberger, Kelsey; Harris, Mallory J.; Burke, Marshall; Mordecai, Erin A.
作者单位：University of Washington; University of Washington Seattle; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Stanford University; Arizona State University; University System of Maryland; University of Maryland College Park; Stanford University; Stanford University; National Bureau of Economic Research
摘要：Climate change is expected to pose significant threats to public health, particularly vector-borne diseases. Despite dramatic recent increases in dengue that many anecdotally connect with climate change, the effect of anthropogenic climate change on dengue remains poorly quantified. To assess this link, we assembled local-level data on dengue across 21 countries in Asia and the Americas. We found a nonlinear relationship between temperature and dengue incidence with the largest impact of 11 to...
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作者：Dhiman, Shikha; Vleugels, Marle E. J.; Post, Richard A. J.; Crippa, Martina; Cardellini, Annalisa; de Korver, Esmee; Su, Lu; Palmans, Anja R. A.; Pavan, Giovanni M.; van der Hofstad, Remco W.; Albertazzi, Lorenzo; Meijer, E. W.
作者单位：Eindhoven University of Technology; Eindhoven University of Technology; Johannes Gutenberg University of Mainz; Erasmus University Rotterdam; Erasmus MC; Polytechnic University of Turin; Leiden University; Leiden University - Excl LUMC; Eindhoven University of Technology; University of New South Wales Sydney; University of New South Wales Sydney
摘要：Multivalent binding and the resulting dynamical clustering of receptors and ligands are known to be key features in biological interactions. For optimizing biomaterials capable of similar dynamical features, it is essential to understand the first step of these interactions, namely the multivalent molecular recognition between ligands and cell receptors. Here, we present the reciprocal cooperation between dynamic ligands in supramolecular polymers and dynamic receptors in model cell membranes,...
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作者：Kaelin Jr, William G.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute
摘要：Up to 10 to 20% of the proteome contains regions with much lower amino acid diversity than would be expected by chance. This year's Lasker Basic Science Award is given to Steven McKnight and Dirk G & ouml;rlich for their pioneering work on such low- complexity domains (LCDs). They showed, using a variety of elegant approaches, that such LCDs can form homotypic and heterotypic interactions that lead to reversible phase separations in cells. These phase separations, which in the laboratory manif...
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作者：Turuban, Regis; Noselli, Giovanni; Beran, Alfred; DeSimone, Antonio
作者单位：Scuola Superiore Sant'Anna; International School for Advanced Studies (SISSA); Istituto Nazionale di Oceanografia e di Geofisica Sperimentale
摘要：Aquatic microorganisms typically inhabit a heterogeneous resource landscape, composed of localized and transient patches. To effectively exploit these resources, they have evolved a wide range of feeding strategies that combine chemotactic motility with active feeding flows. However, there is a notable lack of experimental studies that examine how these active flows shape resource fields to optimize feeding. In particular, the suspected cooperative hydrodynamics provided by groups of cells rem...
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作者：Zhang, Jiazhi; Yu, Qin; Tian, Jiazhuang; Yang, Shanglu; Zuo, Xunwei; Li, Ying; Chen, Nailu; Rong, Yonghua; Ritchie, Robert O.; Lu, Jian
作者单位：Chinese Academy of Sciences; Shanghai Institute of Optics & Fine Mechanics, CAS; University of California System; University of California Berkeley; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shanghai Jiao Tong University; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong; City University of Hong Kong
摘要：Low-cost yet high-performance structural materials have been invariantly sought for modern engineering applications. However, due to the localized stress concentration induced by a high Peierls-Nabarro stress and limited dislocation mobility, increasing material strength usually comes at the expense of ductility and toughness, resulting in a trade-off between strength-ductility/strength-toughness. Here, we report an anomalous phenomenon of dislocation absorption at the crack front, which is un...
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作者：Karapetyan, Sargis; Mwimba, Musoki; Chen, Tianyuan; Yao, Zhujun; Dong, Xinnian
作者单位：Duke University; Duke University; Howard Hughes Medical Institute
摘要：Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth's day-night cycles and regulate responses to environmental signals to gain competitive advantage. While divergent genetic clocks have been studied extensively in bacteria, fungi, plants, and animals, an ancient conserved circadian redox rhythm has been recently reported. However, its biological function and physiological outputs remain elusive. Here, we uncovered the coexistence of redox and genetic r...
