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作者：Chen, Xiangjun; Hwang, Hee Seung; Li, Bihua; Zhao, Yanhua; Ghosh, Koushik; Deng, Lei; Creasey, Elizabeth A.; Ashenberg, Orr; Graham, Daniel B.; Xavier, Ramnik J.
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brigham & Women's Hospital; Harvard University; Harvard Medical School
摘要：Nuclear receptors (NRs) are crucial to integrate metabolite sensing and immune responses in the gut. NR- interacting protein 1 (NRIP1) is an important coregulator of various NRs that has been implicated in inflammatory bowel disease risk, but mechanistic details of how NRIP1 controls NR activities mediating immune homeostasis and inflammation remain elusive. We demonstrate that a missense risk tory cytokine production, ultimately leading to exacerbated intestinal inflammation. Mechanistically,...
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作者：Tewary, Aniruddha; Sengupta, Shreya; Mukherjee, Soumya; Hazra, Nilanjana; Ebright, Yon W.; Ebright, Richard H.; Mukhopadhyay, Jayanta
作者单位：Department of Science & Technology (India); Bose Institute; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; University System of Ohio; University of Toledo; University System of Ohio; University of Toledo
摘要：A 6 cycle in which the initiation factor 6 associates with RNA polymerase (RNAP) core enzyme to permit transcription initiation and dissociates from RNAP core enzyme to permit transcription elongation, has been proposed to occur and to be an essential step for 6-exchange, with all principal 6 factors from all bacteria. These proposals were based on studies of the principal 6 factor of Escherichia coli, 670, which generally, albeit not obligatorily, is released from RNAP upon the transition fro...
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作者：Weed, Lara; Zeitzer, Jamie M.
作者单位：Stanford University; Stanford University
摘要：Seasonal changes in time policy, such as switching between Standard Time (SDT) and Daylight Saving Time (DST), have been adopted by many countries, including the United States. While transitioning between SDT and DST has notable acute negative population health impacts, the chronic impact of these time policies on health has not been well evaluated. To estimate the impact of permanent SDT or DST on health, we modeled the circadian impact of SDT, DST, and Biannual Shifting (BAS) across a year i...
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作者：Di Leonardo, Roberto; Buzas, Andras; Kelemen, Lorand; Toth, David; Toth, Szilvia Z.; Ormos, Pal; Vizsnyiczai, Gaszton
作者单位：Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR)
摘要：Unlike gas molecules at equilibrium, the spatial organization of self-propelled particles can be very sensitive to what happens at the boundaries of their container. Understanding the link between boundary phenomena and bulk stationary distributions could enable the design of optimized container shapes for the geometric control of confined active particles. Here, we propose a boundary method based on the flux transfer formalism typical of radiometry problems, where surface elements transmit an...
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作者：Alber, Daniel S.; Zhao, Shiheng; Jacinto, Alexandre O.; Wieschaus, Eric F.; Shvartsman, Stanislav Y.; Haas, Pierre A.
作者单位：Princeton University; Princeton University; Max Planck Society; Max Planck Society; Simons Foundation; Flatiron Institute; Princeton University
摘要：Tissue deformations during morphogenesis can be active, driven by internal processes, or passive, resulting from stresses applied at their boundaries. Here, we introduce the Drosophila hindgut primordium as a model for studying boundary-driven tissue morphogenesis. We characterize its deformations and show that its complex shape changes can be a passive consequence of the deformations of the active regions of the embryo that surround it. First, we find an intermediate characteristic triangular...
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作者：Filatova, Tatiana; Akkerman, Joos; Bosello, Francesco; Chatzivasileiadis, Theodoros; Ghorbani, Amineh; Ivanova, Olga; Knittel, Nina; Kwakkel, Jan; Lamperti, Francesco; Magliocca, Nicholas R.; Marangoni, Giacomo; Nabernegg, Stefan; Pichler, Anton; Poujon, Adrian; Safarzynska, Karolina; Taberna, Alessandro
作者单位：Harvard University; Delft University of Technology; Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); University of Graz; Scuola Superiore Sant'Anna; University of Warsaw
摘要：Climate policy faces increasingly complex challenges that span multiple human decision scales in nature-society systems. Contemporary climate policy models, while valuable and increasingly versatile in handling spatial and temporal scales, struggle to capture interacting multiscale decisions on the socioeconomic side. This perspective draws attention to the power of coupling among different modeling families, taking integrated assessment models (IAM), computable general equilibrium models (CGE...
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作者：Krishnan, Shanmugarajan; Lee, Somin; Amoozgar, Zohreh; Subudhi, Sonu; Kumar, Ashwin Srinivasan; Posada, Jessica M.; Lindeman, Neal; Lei, Pinji; Duquette, Mark; Steinbuch, Sophie; Charabati, Marc; Huang, Peigen; Andersson, Patrik; Datta, Meenal; Munn, Lance L.; Fukumura, Dai; Jain, Rakesh K.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; University of Bonn; Agenus Inc; Agency for Science Technology & Research (A*STAR); A*STAR - Bioprocessing Technology Institute (BTI); Rockefeller University; Cornell University; Weill Cornell Medicine; University of Notre Dame
摘要：Wnt signaling plays a crucial role for many developmental processes. It is also pivotal in the generation and limited treatment outcomes of glioblastoma (GBM). Here, we identified Wnt7b, which is markedly upregulated in GBM patients, as a determinant of resistance to immune checkpoint blockers (alpha PD1; anti-Programmed Cell Death Protein 1) in a clinically relevant, alpha PD1-resistant GBM murine model with abundant stem cells. We observed that increased levels of Wnt7b and beta-- catenin co...
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作者：Deike, Luc; Zhou, Xiaohui; Rustogi, Paridhi; Stanley, Rachel H. R.; Reichl, Brandon G.; Bushinsky, Seth M.; Resplandy, Laure
作者单位：Princeton University; Princeton University; Princeton University; Wellesley College; National Oceanic Atmospheric Admin (NOAA) - USA; University of Hawaii System; University of Hawaii Manoa
摘要：Bubble-mediated gas exchange associated with wave breaking is a critical pathway for ocean-atmosphere exchange of low solubility gases such as oxygen. Yet, ocean and climate models, as well as observation-based products, usually rely on wind-only air-sea flux formulations derived from carbon constraints that ignore the asymmetric nature of the bubble flux, contributing to discrepancies between estimates of oxygen inventories and their response to climate change. Without bubbles, gas exchange i...
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作者：Donati, Dante; Fong, Hortense
作者单位：Columbia University
摘要：Social media platforms have become vital channels for businesses to reach consumers through advertising. But in the United States, the digital advertising market in which these platforms operate is dominated by a few major players, raising concerns for antitrust regulators. In such a concentrated market, the entry or exit of a single platform can reallocate billions in ad spending, affecting businesses and users. TikTok's temporary suspension in the United States in January 2025 provides a uni...
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作者：Ma, Yeyang; Zhang, Qiuyuan; Li, Dekang; Zhao, Kun; Li, Zefei; Liu, Yuan; Wang, Chu; Sun, Bo; Li, Dan; Yuan, Junying; Liu, Cong
作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Peking University; Chinese Academy of Sciences; Peking University; ShanghaiTech University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University
摘要：The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated. Here, we tracked RIPK1 and RIPK3 coassemblies and found that these fibrillar aggregates could be released into the culture medium after the membrane rupture in necropt...
