38期

最新文章

• Experimental evidence for the continuous transition between elastic and elastoinertial turbulence AI翻译
  作者：Zhang, Yi-Bao; Li, Lu; Fan, Yaning; Su, Jinghong; Xi, Heng-Dong; Sun, Chao
  作者单位：Tsinghua University; Southern University of Science & Technology; Southern University of Science & Technology; China University of Petroleum; Northwestern Polytechnical University; Tsinghua University
  摘要：Elastic turbulence (ET) and elastoinertial turbulence (EIT) of viscoelastic fluids are unique flow states with features distinct from the inertial turbulence of Newtonian fluids. Whether these two states are connected or entirely decoupled remains controversial. We here resolve this controversy by providing experimental evidence of a continuous transition between ET and EIT in Taylor-Couette flow. Through experimentally quantifying the roles of elasticity and inertia in flow stability, we find...
• The balance between microbial arsenic methylation and demethylation in paddy soils underpins global arsenic risk and straighthead disease in rice AI翻译
  作者：Dai, Jun; Chen, Chuan; Zhai, Zhi - Qiang; Gao, A. - Xiang; Johnson, David R.; Kopittke, Peter M.; Zhao, Fang - Jie; Wang, Peng
  作者单位：Nanjing Agricultural University; Nanjing Agricultural University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Bern; University of Queensland
  摘要：Arsenic contamination in rice poses a global challenge to food safety and agricultural productivity, as toxic methylated arsenic species-dimethylarsinic acid (DMA) and its highly toxic derivative, methylated monothioarsenate (DMMTA)-accumulate in rice grains. These arsenic species endanger human health and trigger rice straighthead disease, a crop disorder that drastically reduces yields. However, the microbial ecological processes driving arsenic speciation in paddy soils, and their link to s...
• SLC39A8-mediated zinc dyshomeostasis potentiates kidney disease AI翻译
  作者：Cai, Zhaoxian; Wu, Xiaotian; Wang, Tianyi; Song, Zijun; Ni, Pu; Zhong, Meijuan; Su, Yunxing; Xie, Enjun; Sun, Shumin; Lin, Yangjun; Min, Junxia; Wang, Fudi
  作者单位：Zhejiang University; Zhejiang University; University of South China
  摘要：While numerous genetic risk loci are linked to kidney disease, a unifying therapeutic target for diverse renal pathologies remains elusive. Here, through large-cohort polymorphic locus screening, we identify the SLC39A8 A391T variant (rs13107325) as a shared modifier of multiple kidney diseases. Functional characterization using Slc39a8 A391T knock-in mice and kidney-specific Slc39a8 knockout mice reveals that loss of SLC39A8 function reduces renal zinc accumulation, thereby mitigating suscept...
• Distinct timescales dissociate spontaneous thought dimensions AI翻译
  作者：Hua, Jingyu; Ge, Xianliang; Dou, Min; Zhang, Yuqi; Ge, Liezhong; Fogel, Stuart; Zhang, Jianfeng; Northoff, Georg
  作者单位：Shenzhen University; Zhejiang University; University of Ottawa; University of Ottawa; Shaanxi Normal University
  摘要：Our spontaneous thoughts encompass various dimensions, such as task-relatedness (off vs. on task), and thought orientation (internal vs. external). However, their distinction remains unclear. Our study addresses this issue by focusing on their timescales at both the behavioral level (using fast and slow finger tapping) and the neural level (using EEG) using two independent datasets (N = 84 and 35). Behavioral results revealed a double dissociation: Task-relatedness was linked to fast tapping o...
• PI31 expression is neuroprotective in a mouse model of early- onset parkinsonism AI翻译
  作者：Rodriguez, Jose A.; Minis, Adi; Aref, Rasha; Nguyen, Hieu Hoang Minh; Sun, Fiona; Steller, Hermann; Chao, Moses
  作者单位：Rockefeller University; Stanford Medicine; Stanford University
  摘要：Neurodegenerative diseases present one of the most significant global health challenges. These disorders are defined by the accumulation of abnormal protein aggregates that impair synaptic function and cause progressive neuronal degeneration. Therefore, stimulating protein clearance mechanisms may be neuroprotective. Variants in FBXO7/ PARK15 cause Parkinsonian Pyramidal Syndrome, an early-onset parkinsonian neurodegenerative disorder in humans, and inactivation of this gene in mice recapitula...
• Engineering a serum response factor superactivator of smooth muscle gene expression with a condensate-forming domain AI翻译
  作者：Gan, Peiheng; Zhou, Xinyi; Shah, Akansha M.; Bezprozvannaya, Svetlana; Chen, Kenian; Ding, Qianqian; Li, Hui; Xu, Lin; Liu, Ning; Olson, Eric N.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Texas System; University of Texas Southwestern Medical Center
  摘要：Differentiation of smooth muscle cells (SMCs) is driven by the activation of a set of genes controlled by serum response factor (SRF), a ubiquitous transcription factor with limited intrinsic transcriptional activity. Myocardin (MYOCD) is a strong transcriptional coactivator that orchestrates smooth muscle differentiation through its association with SRF. MYOCD forms nuclear condensates via its intrinsically disordered transcription activation domain (TAD), whereas SRF is diffusely distributed...
• Amplification of particle collision through contact electrification in isotropic turbulence AI翻译
  作者：Johnson, Danielle R.; Bocanski, Adam; Diorio, Emily M.; Chen, James; Meng, Hui
  作者单位：State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY
  摘要：Recent discovery of extreme clustering of inertial particles in isotropic turbulent flow suggests a hidden mechanism of particle-particle interaction at sub-Kolmogorov separations unexplained by hydrodynamic interaction. The near-contact radial distribution function (RDF) reaches O(104), resulting in a collision kernel four orders larger than direct numerical simulation predictions. Statistical stationarity is lost in the particle-laden turbulence, suggesting the particles experience a nonequi...
• More 26S and 30S proteasomes are beneficial in proteinopathy AI翻译
  作者：Kim, Youngwon; Kim, Namhoon; Lee, Wonjae; Kim, Youbin; Kim, Donghyeon; Park, Jisu; Jung, Yong-Keun
  作者单位：Seoul National University (SNU); Seoul National University (SNU); University of Texas System; UTMD Anderson Cancer Center
  摘要：Despite the many studies on the ubiquitin-proteasome system, our understanding of the proteasome itself is limited. The balance and regulation of 26S and 30S proteasomes are not yet known. Here, we show that among the proteasome base assembly chaperones, only S5b/PSMD5 determines the levels of proteasome holoenzymes, especially the 30S proteasome, in mammals. In a variety of cell lines and mouse tissues, we found that apart from its role in yeast 19S proteasome assembly, loss of S5b/PSMD5 incr...
• Weighted active space protocol for multireference machine-learned potentials AI翻译
  作者：Seal, Aniruddha; Perego, Simone; Hennefarth, Matthew R.; Raucci, Umberto; Bonati, Luigi; Ferguson, Andrew L.; Parrinello, Michele; Gagliardi, Laura
  作者单位：University of Chicago; University of Chicago; Istituto Italiano di Tecnologia - IIT; University of Chicago
  摘要：Multireference methods such as multiconfiguration pair-density functional theory accurately capture electronic correlation in systems with strong multiconfigurational character, but their cost precludes direct use in molecular dynamics. Combining these methods with machine-learned interatomic potentials (MLPs) can extend their reach. However, the sensitivity of multireference calculations to the choice of the active space complicates the consistent evaluation of energies and gradients across s...
• Differential representations of spatial location by aperiodic and alpha oscillatory activity in working memory (vol 122, e2506418122, 2025) AI翻译
  作者：Bender, Andrew; Zhao, Chong; Vogel, Edward; Awh, Edward; Voytek, Bradley