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作者：Chae, Rebecca L.; Siddiqui, Rafay; Xu, Yan
作者单位：Santa Clara University; Virginia Polytechnic Institute & State University
摘要：The urgent calls for action on climate change underscore the importance of increasing sustainable behavior among individuals who have traditionally veered away from it, such as those on the political right. Utilizing data from four geopolitical regions across 24 countries, we explore whether vulnerability to natural disasters, brought on by either experiencing or anticipating a natural disaster, is a crucial factor. We find that as vulnerability to natural disasters increases, sustainable cons...
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作者：Jin, Guang-Bo; Rong, Shao-Qin; Yin, Dong-Rui; Deng, Zhou-Hao; Ding, Xiao; Sheng, Meng-Yao; Gao, Hai; Kohli, Rahul M.; Xu, Guo-Liang; Zhou, Dan
作者单位：Fudan University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Fudan University
摘要：Ten- eleven translocation (TET) enzymes oxidize 5- methylcytosine (mC) in DNA, contributing to the regulation of gene transcription. Diverse mutations of TET2 are frequently found in various blood cancers, yet the full scope of their functional consequences has been unexplored. Here, we report that a subset of TET2 mutations identified in leukemia patients alter the substrate specificity of TET2 from acting on mC to thymine. This neomorphic activity results from substitutions at key residues i...
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作者：Qian, Xu; Zhou, Qimin; Ouyang, Yuan; Wu, Xiaohong; Sun, Xue; Wang, Shuo; Duan, Yuran; Hu, Zhiqiang; Hou, Yueru; Wang, Zheng; Chen, Xiaohan; Wang, Katherine L.; Shen, Yuli; Dong, Bofei; Lin, Yanni; Wen, Ting; Tian, Qi; Guo, Zhanpeng; Li, Min; Xiao, Liwei; Wu, Qingang; Meng, Ying; Liu, Guijun; Ying, Hangjie; Zhou, Yahui; Zhang, Wuchang; Duan, Shengzhong; Bai, Xueli; Liu, Tong; Zhan, Peng; Lu, Zhimin; Xu, Daqian
作者单位：Zhejiang Cancer Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Zhejiang University; Zhejiang University; Zhejiang University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Harbin Medical University; Harbin Medical University; Shandong University; Zhejiang University; Harbin Medical University
摘要：Tumor cells reshape iron and lipid metabolism for their rapid proliferation. However, how tumor cells coordinate the interplay between tumor cell-specific iron homeo-stasis and lipid metabolism reprogramming to counteract energy shortages remains unclear. Here, we demonstrated that glucose deprivation in hepatocellular carci-noma (HCC) cells induced AMPK- dependent Transferrin S685 phosphorylation, which exposed Transferrin nuclear localization signal (NLS) for binding to importin alpha 7 and ...
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作者：Boomsma, Jacobus J.
作者单位：University of Copenhagen
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作者：Kaye, Thomas G.; Bak, Judyta; Marcelo, Henry William; Pittman, Michael
作者单位：Jagiellonian University; Chinese University of Hong Kong; University of London; University College London
摘要：Tattoos were a prevalent art form in pre- Hispanic South America exemplified by mummified human remains with preserved skin decoration that reflects the personal and cultural representations of their times. Tattoos are known to fade and bleed over time and this is compounded in mummies by the decay of the body, inhibiting the ability to examine the original art. Laser- stimulated fluorescence (LSF) produces images based on fluorescence emitted from within the target. Here, we present the first...
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作者：Wang, Hui J.; Fan, Weiwei; Liu, Sihao; Kim, Kyeongkyu; Matsushima, Ayami; Ogawa, Satoshi; Kang, Hyun Gyu; Zhu, Jonathan; Estepa, Gabriela; He, Mingxiao; Crossley, Lillian; Liddle, Christopher; Kim, Minseok S.; Truitt, Morgan L.; Yu, Ruth T.; Atkins, Annette R.; Downes, Michael; Evans, Ronald M.
作者单位：Salk Institute; Kyushu University; University of Sydney; Westmead Institute for Medical Research; University of Sydney; Daegu Gyeongbuk Institute of Science & Technology (DGIST)
摘要：Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma deletion of BCL6 at either perinatal or adult stages profoundly reduces muscle mass and compromises muscle strength. Conversely, muscle- directed viral overexpressi...
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作者：Yoneyama, Yosuke; Zhang, Ran-Ran; Maezawa, Mari; Masaki, Hideki; Kimura, Masaki; Cai, Yuqi; Adam, Mike; Parameswaran, Sreeja; Mizuno, Naoaki; Bhadury, Joydeep; Maezawa, So; Ochiai, Hiroshi; Nakauchi, Hiromitsu; Potter, S. Steven; Weirauch, Matthew T.; Takebe, Takanori
作者单位：University of Osaka; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Stanford University; Tokyo University of Science; Kyushu University; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center
摘要：Intercellular transmission of messenger RNA (mRNA) is being explored in mammalian species using immortal cell lines. Here, we uncover an intercellular mRNA transfer phenomenon that allows for the adaptation and reprogramming of human primed pluripotent stem cells (hPSCs). This process is induced by the direct cell contact- mediated coculture with mouse embryonic stem cells under the condition impermissible for primed hPSC culture. Mouse- derived mRNA contents are transmitted into adapted hPSCs...
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作者：Zhang, Jiaojiao; Xu, Jiayi; Wang, Xinman; Liu, Ying; Li, Shuangtao; Zhang, Jialong; He, Lingfeng; Guo, Luqin; Li, Chonghua; Li, Xin - Xu; Guo, Yang - Dong; Zhang, Na
作者单位：China Agricultural University; Hebei Normal University of Science & Technology; Shanghai Academy of Agricultural Sciences; Beijing Academy of Agriculture & Forestry Sciences (BAAFS)
摘要：Light serves as an energy source for cell division and expansion during fruit development. Cell expansion significantly influences fruit size and is closely linked to endoreduplication, a unique cell cycle variation characterized by DNA replication without cytokinesis. Paradoxically, under conditions of ample photosynthates, light signaling suppresses cell expansion. The intricate regulation of endoreduplication in response to light signaling during fruit development has remained an intriguing...
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作者：Biswas, Nilima; Mori, Tommaso; Nagaraj, Naresh Kumar Ragava Chetty; Xin, Hong; Diemer, Tanja; Li, Pin; Su, Yongxuan; Piermarocchi, Carlo; Ferrara, Napoleone
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Michigan State University; University of California System; University of California San Diego; China Pharmaceutical University
摘要：We hypothesized that a strategy employing tissue- specific endothelial cells (EC) might facilitate the identification of tissue- or organ- specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water- soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4lym- phoma extracts. ADP stimulated the growth of bovine choroidal EC (BCEC) an...
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作者：Jury, Christopher P.; Bahr, Keisha D.; Cros, Annick; Dobson, Kerri L.; Freel, Evan B.; Graham, Andrew T.; McLachlan, Rowan H.; Nelson, Craig E.; Price, James T.; de Souza, Mariana Rocha; Shizuru, Leah; Smith, Celia M.; Sparagon, Wesley J.; Squair, Cheryl A.; Timmers, Molly A.; Vicente, Jan; Webb, Maryann K.; Yamase, Nicole H.; Grottoli, Andrea G.; Toonen, Robert J.
作者单位：University of Hawaii System; University of Hawaii Manoa; Texas A&M University System; Nature Conservancy; NERC National Oceanography Centre; University of Southampton; University System of Ohio; Ohio State University; Oregon State University; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; University of Hawaii System; University of Hawaii Manoa; National Geographic Society
