2025

最新文章

• Reply to Cummins et al.: GPT reveals cognitive dissonance that is both irrational and alarmingly humanlike AI翻译
  作者：Lehr, Steven A.; Saichandran, Ketan S.; Harmon-Jones, Eddie; Vitali, Nykko; Banaji, Mahzarin R.
  作者单位：Boston University; University of New South Wales Sydney; Harvard University
• Specificities of chemosensory receptors in the human gut microbiota AI翻译
  作者：Xu, Wenhao; Khayrova, Ekaterina Jalomo -; Gumerov, Vadim M.; Ross, Patricia A.; Kobel, Tania S.; Schindler, Daniel; Bange, Gert; Zhulin, Igor B.; Sourjik, Victor
  作者单位：Max Planck Society; Philipps University Marburg; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University
  摘要：The human gut is rich in metabolites and harbors a complex microbial community, yet surprisingly little is known about the spectrum of chemical signals detected by the large variety of sensory receptors present in the gut microbiome. Here, we systematically mapped the ligand specificities of selected extracytoplasmic sensory domains from twenty members of the human gut microbiota, with a primary focus on the abundant and physiologically important class of Clostridia. Twenty- five metabolites f...
• ER-resident CCDC134 safeguards TLR4 maturation by maintaining gp96 stability AI翻译
  作者：Bai, Yang; Zhang, Chao; Liu, Hao; Deng, Fan; Wu, Zeyu; Deng, Wanyan; Zheng, Zengzhang; Min, Rui; Mei, Shenglin; Kang, He; Yu, Huiqing; Pan, Youdong; Lieberman, Judy; Zhao, Jingxia; Liu, Xing
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chongqing Medical University; Tongji University; Virginia Polytechnic Institute & State University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard University; Harvard Medical School; Capital Medical University
  摘要：Toll-like receptor 4 (TLR4), a pattern-recognition receptor located on the plasma membrane, senses extracellular danger signals to initiate inflammatory immune responses. It is initially synthesized in the endoplasmic reticulum (ER), undergoes N-linked glycosylation, and is subsequently transported to the Golgi before ultimately reaching the plasma membrane. However, the mechanisms underlying the processing and maturation of TLR4 in the ER remain elusive. Through whole genome-wide CRISPR scree...
• Aspartic acid residues in BBE- like enzymes from Morus alba promote a function shift from oxidative cyclization to dehydrogenation AI翻译
  作者：Guo, Nianxin; Gu, Jun; Zhou, Qingyang; Liu, Fang; Dong, Haoran; Ding, Qi; Wang, Qixuan; Wu, Dongshan; Yang, Jun; Fan, Junping; Gao, Lei; Houk, Kendall N.; Lei, Xiaoguang
  作者单位：Peking University; Peking University; Chinese Academy of Sciences; Peking University; Nanjing University of Science & Technology; University of California System; University of California Los Angeles; Nanjing Agricultural University; Wuhan University
  摘要：Berberine bridge enzyme (BBE)-like enzymes catalyze various oxidative cyclization and dehydrogenation reactions in natural product biosynthesis, but the molecular mechanism underlying the selectivity remains unknown. Here, we elucidated the catalytic mechanism of BBE-like oxidases from Morus alba involved in the oxidative cyclization and dehydrogenation of moracin C. X-ray crystal structures of a functionally promiscuous flavin adenine dinucleotide (FAD)-bound oxidase, MaDS1, with and without ...
• Indigenous fire stewardship shaped North American Great Lakes forests AI翻译
  作者：Larson, Evan R.; Montano, Nisogaabokwe Melonee; Lockling, Emily; Ojibway, Ashla; Reynolds, Mocha B.; Zhaawendaagozikwe, Valerie Ross; Johnson, Lane B.; Kipfmueller, Kurt F.; Dockry, Michael J.; Northrup, Vern; Savage, Jeff; Kimmerer, Robin Wall
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota System; University of Minnesota Twin Cities; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry
  摘要：Interest in bringing Traditional Ecological Knowledge (TEK) and Western Science together to enhance climate and landscape resilience is growing rapidly, particularly for engagement with pyrogenic communities around the world. For these systems, Indigenous Knowledge offers unique insights that reflect millennia of intimate engagement with local landscapes, while Western Science can offer additional understanding of the emergence of climates and ecological conditions that are novel at evolutiona...
• Structural basis and affinity improvement for an ATP-binding AI翻译
  作者：Jiang, Yan; Zhang, Yuchao; Wan, Liqi; Cui, Cheng; Guo, Pei; Han, Da; Tan, Weihong; Patel, Dinshaw
  作者单位：Hunan University; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Shanghai Jiao Tong University
  摘要：DNA aptamers that bind small molecules with high affinity have revolutionized the fields of biosensing and bioimaging. Recently, a DNA aptamer named 1301b has been identified as the most potent DNA aptamer for the binding of adenosine triphosphate (ATP) with a dissociation constant (K-D) of similar to 2.7 mu M. However, the structural basis and recognition mechanism remain unclear, hindering further development of this DNA aptamer. In this study, we first design a shortened DNA aptamer namely ...
• Logarithmic kinetics and bundling in random packings of elongated 3D physical links AI翻译
  作者：Bonamassa, Ivan; Rath, Balazs; Posfai, Marton; Abert, Miklos; Keliger, Daniel; Szegedy, Balazs; Kertesz, Janos; Lovasz, Laszlo; Barabasi, Albert-Laszlo
  作者单位：Budapest University of Technology & Economics; Northeastern University
  摘要：We explore the impact of excluded volume interactions on the local assembly of linear physical networks, where nodes are spheres and links are rigid cylinders with varying length. To focus on the effect of elongated links, we introduce a minimal 3D model that helps us zoom into confined regions of these networks whose distant parts are sequentially connected by the random deposition of physical links with a very large aspect ratio. We show that the nonequilibrium kinetics at which these elonga...
• Role of wettability, adhesion, and instabilities in transitions during lubricated sliding friction AI翻译
  作者：Dong, Hao; Siddiquie, Reshma Y.; Xiao, Xuemei; Andrews, Michael; Bergman, Brian; Hui, Chung-Yuen; Jagota, Anand
  作者单位：Lehigh University; Lehigh University; Cornell University; Michelin
  摘要：Lubricated contacts in soft materials are important in various engineering systems and natural settings. Three major lubrication regimes are boundary (BL), mixed (ML), and elastohydrodynamic (EHL) lubrication, where the contact region is dry, partially wetted, or fully wetted, respectively. The transition between these regimes is insufficiently understood, especially for soft contacts, which impedes desired control of lubricated sliding friction. Here, we report on the role of solid wettabilit...
• Spatiotemporal distribution of the glycoprotein pherophorin II reveals stochastic geometry of the growing ECM of Volvox carteri AI翻译
  作者：von der Heyde, Benjamin; Srinivasan, Anand; Birwa, Sumit Kumar; von der Heyde, Eva Laura; Hoehn, Steph S. M. H.; Coldstein, Raymond E.; Hallmann, Armin
  作者单位：University of Bielefeld; University of Cambridge
  摘要：The evolution of multicellularity involved the transformation of a simple cell wall of unicellular ancestors into a complex, multifunctional extracellular matrix (ECM). A suitable model organism to study the formation and expansion of an ECM during ontogenesis is the multicellular green alga Volvox carteri, which, along with the related volvocine algae, produces a complex, self-organized ECM composed of multiple substructures. These self-assembled structures primarily consist of hydroxyproline...
• Targeted deletions of large syntenic regions in Arabidopsis thaliana AI翻译
  作者：Papikian, Ashot; Rattner, Rachel J.; Kao, Jenni; Hauser, Neil; Allsing, Nicholas; Mamerto, Allen; Hartwick, Nolan T.; Colt, Kelly; Michael, Todd P.
  作者单位：Salk Institute; University of California System; University of California San Diego; University of California System; University of California San Diego
  摘要：Plant genomes have undergone multiple rounds of whole-genome duplication (WGD) throughout their evolutionary history. As a result, many species, including Arabidopsis thaliana, retain duplicated genomic segments, or syntenic regions, which harbor large numbers of paralogous genes preserved from these ancient WGD events. We deleted four large, duplicated blocks, ranging from similar to 115 kb to similar to 684 kb using Staphylococcus aureus Cas9 to explore the effects of knocking out these bloc...