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作者：Bunin, Guy; Rivoire, Olivier
作者单位：Technion Israel Institute of Technology; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI)
摘要：We present a simple physical model that recapitulates several features of biological evolution, while being based only on thermally driven attachment and detachment of elementary building blocks. Through its dynamics, this model samples a large and diverse array of nonequilibrium steady states, both within and between independent trajectories. These dynamics exhibit directionality with a quantity that increases in time, selection, and preferential spatial expansion of particular states, as wel...
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作者：Clegg, Tom; Gross, Thilo
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作者：Luan, Qing; Clark, Patricia L.
作者单位：University of Notre Dame
摘要：Our current understanding of protein folding is based predominantly on studies of small (<150 aa) proteins that refold reversibly from a chemically denatured state. However, as protein length increases so does the competition between off-pathway misfolding and on-pathway folding, creating a more complex energy landscape (folding funnel). Little is known about how intermediates populated during the folding of larger proteins affect navigation of this more complex landscape. Previously, we repor...
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作者：Bailles, Anais; Serafini, Giulia; Andreas, Heino; Zechner, Christoph; Modes, Carl D.; Tomancak, Pavel
作者单位：Max Planck Society
摘要：During development, groups of cells generate shape by coordinating their mechanical properties through an interplay of self-organization and prepatterning. Hydra displays a striking planar pattern of actin fibers at the organism scale, and mechanics influence the morphogenesis of biological structures during its prepatterned regeneration. However, how mechanics participate in the formation of an ordered pattern from a totally disordered state remains unknown. To study this, we used cellular ag...
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作者：Zhong, Kevin Xu; Chan, Amy M.; Miller, Kristina M.; Saunders, Rob; Suttle, Curtis A.
作者单位：University of British Columbia; Fisheries & Oceans Canada; University of British Columbia; University of British Columbia; University of British Columbia
摘要：Metatranscriptomic data from a mass-mortality event of adult Pacific Oysters, Crassostrea (Magallana) gigas, the most widely cultivated shellfish globally, revealed a nidovirus shown to replicate in a bivalve, Pacific Oyster Nidovirus 1 (PONV1). At 64,331 bp of linear bisegmented, positive-sense single-stranded RNA, PONV1 has one of the largest genomes reported for an RNA virus. Moreover, transcriptomic data reveal that many conspecific viruses of PONV1 occur in Pacific oysters from Europe and...
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作者：Nemhauser, Jennifer L.; Weigel, Detlef
作者单位：University of Washington; University of Washington Seattle
摘要：Joanne Chory (1955-2024) was a pioneering biologist whose research transformed our understanding of plant growth and development. Her groundbreaking work, based on many clever genetic screens, established a complete signaling pathway for brassinosteroids, from the biosynthesis of this important class of plant hormones and their transmembrane receptor to cytoplasmic and nuclear effectors. A beloved mentor and visionary leader, Chory championed science as both a rigorous discipline and a force f...
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作者：Piekarski, Patrick K.; Valdes-Rodriguez, Stephany; Trible, Waring; Kronauer, Daniel J. C.
作者单位：Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; Harvard University
摘要：Polyphenic traits in animals often exhibit nonlinear scaling with body size. Static allometries (i.e., scaling relationships) themselves can exhibit plasticity, such that individuals of the same size and genotype differ in body proportions across different environments. In ants, both larval environment and genotype regulate the expression of caste- associated traits, including body size and ovariole number. However, it remains untested whether caste- associated traits are independently regulat...
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作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
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作者：Guo, Jun-Chen; Chai, Cong-Zheng; Wang, Ya-Hui; Zhao, Yao; Xin, Sen; Zhang, Ying; Guo, Yu-Guo; Bai, Chunli
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Chemistry, CAS
摘要：Lithium (Li) metal batteries offer high energy density but face significant safety challenges due togas evolution under thermal abuse conditions. At the anode, the reduction of organic carbonate-based electrolytes generates flammable gases (e.g., H2, CH4), while the poor thermal stability of the cathode results in the release of O2, CO, and CO2. The accumulation of these gases contributes to mechanical rupture, and their migration further exacerbates thermal runaway. To address these challenge...
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作者：Liu, Shuting; Chen, Junyao; Chen, Haiqiao; Guo, Yanan; Yuan, Fa; Xiao, Dongchang; Xiang, Mengqing
作者单位：Sun Yat Sen University; Sun Yat Sen University
摘要：The retinal photoreceptors possess specialized sensory cilia critical for phototransduction while the nonphotoreceptor cells typically exhibit simpler primary cilia or lack them altogether. This dichotomy in ciliary architecture underpins the functional specialization of retinal cell types, but how this dichotomy arises and is maintained remains elusive. This study explores the role of the transcription factor Foxn3 in establishing and maintaining this divergence. We generated retina-specific ...
