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作者：Yanai, Shogo; Sasaki, Junko; Lee-Okada, Hyeon-Cheol; Takahashi, Fumiya; Kikuchi, Yuto; Morioka, Shin; Yamamoto, Toshiyoshi; Yuguchi, Katsuya; Oikawa, Miko; Kajiho, Hiroaki; Baba, Takashi; Yokoyama, Chikako; Morohashi, Ken-Ichirou; Suzuki, Akira; Yokomizo, Takehiko; Sasaki, Takehiko
作者单位：Juntendo University; Kyushu University; Kyushu University; Kurume University; Kobe University
摘要：Adrenal lipomas are benign tumors containing ectopic adipose tissue in the adrenal gland, an organ that normally lacks both adipocytes and their progenitors. The origin of this ectopic fat remains enigmatic, and the absence of a genetic animal model has key signaling lipid that regulates cellular growth and differentiation, is tightly regulated by the lipid phosphatases PTEN (phosphatase and tensin homolog) and SHIP2 (SH2- containing inositol phosphatase 2). Here, we demonstrate that simultane...
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作者：Ritt, Daniel A.; Durrant, David E.; Drew, Matthew R.; Sandin, Suzanne I.; Fiesco, Juliana A. Martinez; Zhang, Xiaohua; Aydin, Fikret; Carpenter, Timothy S.; Scheidemantle, Grace M.; D'Ippolito, Robert A.; Sohn, Alexandria L.; Dehart, Caroline J.; Shrestha, Rebika; Snead, Kelly; Hull, Jenna; Tempkin, Jeremy O. B.; Yang, Yue; Lightstone, Felice C.; Streitz, Frederick H.; Zhang, Ping; Turbyville, Thomas J.; Stephen, Andrew G.; Esposito, Dominic; Ingolfsson, Helgi I.; Nissley, Dwight, V; Morrison, Deborah K.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：The RAF kinases (ARAF, BRAF, and CRAF) are essential components of the RAS-ERK signaling pathway, which controls vital cellular processes and is frequently dysregulated in human disease. Notably, mutations that alter BRAF function are prominent drivers of human cancer and certain RASopathy disorders, making BRAF an important target for therapeutic intervention. Despite extensive research, several aspects of BRAF regulation remain unclear. In this study, we developed an in vitro BRAF activation...
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作者：Li, Wenjing; Feng, Yifan; Xu, Zhouyang; Xu, Xing; Yang, Kexin; Yao, Xinya; Pan, Jia- Ji; Cui, Hengxiang; Hu, Ji; Cheng, Bingbing
作者单位：ShanghaiTech University; ShanghaiTech University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; ShanghaiTech University
摘要：Precise, noninvasive drug delivery to small but important brain regions is challenging and highly desired given the brain's inherent complexity and heterogeneous nature. Here, we report an approach utilizing focused ultrasound (FUS) combined with nanobubbles to successfully navigate this challenge. Compared to traditional microbubbles, nanobubbles exhibit superior acoustic properties. The nanobubbles, when exposed to FUS, induce a highly localized and reversible opening of the blood-brain barr...
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作者：Melamed, Daniel; Shemer, Revital; Bolotin, Evgeni; Yakass, Michael B.; Fink-Barkai, Dorit; Hiadzi, Edem K.; Skorecki, Karl L.; Livnat, Adi
作者单位：University of Haifa; University of Haifa; Technion Israel Institute of Technology; Rappaport Faculty of Medicine; Technion Israel Institute of Technology; University of Ghana; Bar Ilan University; Rambam Health Care Campus
摘要：Mutation rates have long been measured as averages across many genomic positions. Recently, a method to measure the rates of individual mutations was applied to a narrow region in the human hemoglobin subunit beta (HBB) gene containing the site of the hemoglobin S (HbS) mutation as well as to a paralogous hemoglobin subunit delta (HBD) region, in sperm samples from sub-Saharan African and northern European donors [Melamed etal., Genome Res. 32, 488-498 (2022)]. The HbS mutation, which protects...
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作者：Perla, Sravan; Stiegler, Amy L.; Yi, Jae-Sung; Enyenihi, Liz; Zhang, Lei; Riaz, Muhammad; An, Elvira; Qyang, Yibing; Boggon, Titus J.; Bennett, Anton M.
作者单位：Yale University; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Yale University; Yale University; Yale University
摘要：Noonan syndrome with multiple lentigines (NSML) is a rare autosomal dominant disorder caused by mutations in PTPN11 (protein tyrosine phosphatase nonreceptor type 11) which encodes for the protein tyrosine phosphatase, SHP2. Approximately 85% of NSML patients develop hypertrophic cardiomyopathy (HCM). Here, we show that SHP2 is recruited to tyrosyl phosphorylated protein-zero related (PZR) in NSML mice. This recruitment is required for the Iroquois homeobox (IRX) transcription factors 3 and 5 ...
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作者：Waisertreiger, Irina; Ayele, Kalkidan; Elshaikh, Mehad Hilal; Barlow, Jacqueline H.
作者单位：University of California System; University of California Davis
摘要：DNA secondary G-quadruplex (G4) structures can impair and even obstruct DNA replication. Defects in processing G4 structures are associated with replication stress, a common property of both B cell cancers and hyperproliferative premalignant cells. Genome instability arising from replication stress is a hallmark of cancer and strongly contributes to the chromosome rearrangements in B cell cancers. Here, we define the impact of G4-stabilizing ligands on generating genome instability in primary ...
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作者：Broccoli, Anthony J.
作者单位：Rutgers University System; Rutgers University New Brunswick
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作者：Lee, Jongsun; Lee, Bora; Lee, Hyein; Kim, Eun Ji E.; Kim, Sieun S.; Kwon, Hyunwoo C.; Lee, Hanseul; Lee, Gee - Yoon; Hong, Woojin; Ham, Seokjin; Yang, Jae Won; Park, Heeju; Moreno, Tatiana M.; Brown, Michelle E.; Park, Hae- Eun H.; Kim, Eunah; Jung, Yoonji; Kang, Eunseok; Park, Sangsoon; Shin, Yeo Jin; Ha, Seokjun G.; Kwon, Sujeong; Hwang, Seungjae; Min, Hyemin; Kumsta, Caroline; Lim, Chunghun; Kang, Chanhee; Seo, Jinsoo; Lee, Kwang-Pyo; Leea, Seung-Jae, V
作者单位：Korea Advanced Institute of Science & Technology (KAIST); Korea Research Institute of Bioscience & Biotechnology (KRIBB); Daegu Gyeongbuk Institute of Science & Technology (DGIST); Yonsei University; Korea Research Institute of Bioscience & Biotechnology (KRIBB); University of Science & Technology (UST); University of Science & Technology (UST); Ulsan National Institute of Science & Technology (UNIST); Sanford Burnham Prebys Medical Discovery Institute; Sanford Burnham Prebys Medical Discovery Institute; Seoul National University (SNU)
摘要：Ribosome-associated quality control (RQC) is a pivotal biological process that governs the fidelity of messenger RNA (mRNA) homeostasis and protein synthesis. Defects in RQC are implicated in cellular dysfunction and proteotoxicity, but their impact on aging remains elusive. Here, we show that Pelota, the ribosome rescue factor, promotes longevity and protects against age-related pathological phenotypes in multiple metazoan species. By performing a targeted genetic screen, we find that Pelota ...
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作者：Zrimec, Jan; Correa, Sandra; Zagorscak, Maja; Petek, Marko; Bleker, Carissa; Stare, Katja; Schuy, Christian; Sonnewald, Sophia; Gruden, Kristina; Nikoloski, Zoran
作者单位：National Institute of Biology - Slovenia; University of Potsdam; Max Planck Society; University of Erlangen Nuremberg
摘要：Understanding the molecular mechanisms behind plant response to stress can enhance breeding strategies and help us design crop varieties with improved stress tolerance, yield, and quality. To investigate resource redistribution from growth- to defense- related processes in an essential tuber crop, potato, here we generate a large- scale compartmenreconstruction of primary metabolism, the model includes the full known potato secondary metabolism, spanning over 566 reactions that facilitate the ...
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作者：Kim, Hojin; Livermore, Samantha M.; Rowan, Stuart J.; Jaeger, Heinrich M.
作者单位：University of Chicago; University of Chicago; University of Chicago; University of Chicago
摘要：In materials, the ability to retain the memory of applied stresses or strains opens up new opportunities for enhancing their performance adaptively via training. In dense suspensions, a stress-adaptive response is enabled by non-Newtonian rheology; however, typical suspensions have little memory, which implies rapid cessation of any adapted behavior. Here, we show how multiple adaptive responses can be achieved by designing suspensions where different stress levels trigger different memories. ...
