2025

最新文章

• CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation AI翻译
  作者：Younis, Doulathunnisa Ahamed; Marosvari, Mason; Liu, Wei; Pulikkot, Sunitha; Cao, Ziming; Zhou, Beiyan; Vella, Anthony T.; Mcardle, Sara; Hu, Liang; Chen, Yunfeng; Gan, Wenqi; Yu, Ji; Bruscia, Emanuela M.; Fan, Zhichao
  作者单位：La Jolla Institute for Immunology; Shanghai University of Traditional Chinese Medicine; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Yale University
  摘要：Monocytes are critical in controlling tissue infections and inflammation. Monocyte dysfunction contributes to the inflammatory pathogenesis of cystic fibrosis (CF) caused cally relevant disease model for studying the contribution of monocytes to inflammation. Although CF monocytes exhibited adhesion defects, the precise mechanism is unclear. Herein, superresolution microscopy showed that an integrin clustering but not an integrin activation defect determines the adhesion defect in CFTR- defici...
• The androgen clock is an epigenetic predictor of long- term male hormone exposure AI翻译
  作者：Sugrue, Victoria J.; Prescott, Melanie; Glendining, Kelly A.; Bond, Donna M.; Horvath, Steve; Anderson, Greg M.; Garratt, Michael; Campbell, Rebecca E.; Hore, Timothy A.
  作者单位：University of Otago; University of Otago; University of California System; University of California Los Angeles
  摘要：Aging is a complex process characterized by biological decline and a wide range of molecular alterations to cells, including changes to DNA methylation. In this study, we used a male- specific epigenetic marker of aging to build an epigenetic predictor that measures long- term androgen exposure in sheep and mice (median absolute error of 4.3 and 1.4 mo, respectively). We term this predictor the androgen clock and show its tick is mediated by the androgen receptor and can be accelerated beyond ...
• A conifer metabolite corrects episodic ataxia type 1 by voltage sensor- mediated ligand activation of Kv1.1 AI翻译
  作者：Manville, Rian W.; Foglia, Lorenzo; Yoshimura, Ryan F.; Hogenkamp, Derk J.; Nguyen, Amy; Yu, Alvin; Abbott, Geoffrey W.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Loss- of- function sequence variants in KCNA1, which encodes the voltage- gated potassium channel Kv1.1, cause Episodic Ataxia Type 1 (EA1) and epilepsy. Due to a paucity of drugs that directly rescue mutant Kv1.1 channel function, current therapeutic strategies for KCNA1- linked disorders involve indirect modulation of neuronal excitability. Native Americans have traditionally used conifer extracts to treat paralysis, weakness, and pain, all of which may involve altered electrical activity an...
• Nonapoptotic role of EGL-1 in exopher production and neuronal health in Caenorhabditis elegans AI翻译
  作者：Wu, Zheng; Cardona, Eric A.; Cohn, Jesse A.; Pierce, Jonathan T.
  作者单位：University of Texas System; University of Texas Austin
  摘要：While traditionally studied for their proapoptotic functions in activating the caspase, research suggests BH3-only proteins also have other roles such as mitochondrial dynamics regulation. Here, we find that EGL-1, the BH3-only protein in Caenorhabditis elegans, promotes the cell-autonomous production of exophers in adult neurons. Exophers are large, micron-scale vesicles that are ejected from the cell and contain cellular components such as mitochondria. EGL-1 facilitates exopher production p...
• The origin of color categories AI翻译
  作者：Garside, Daniel J.; Chang, Audrey L. Y.; Selwyn, Hannah M.; Conway, Bevil R.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH)
  摘要：To what extent does concept formation require language? Here, we exploit color to address this question and ask whether macaque monkeys have color concepts evident as categories. Macaques have similar cone photoreceptors and central visual circuits to humans, yet they lack language. Whether Old World monkeys such as macaques have consensus color categories is unresolved, but if they do, then language cannot be required. If macaques do not have color categories, then color categories in humans ...
• Across the firewall: Foreign media's role in shaping Chinese social media narratives on the Russo-Ukrainian War AI翻译
  作者：Hanley, Hans W. A.; Lu, Yingdan; Pan, Jennifer
  作者单位：Stanford University; Northwestern University; Stanford University
  摘要：There is a widespread perception that China's digital censorship distances its people from the global internet, and the Chinese Communist Party, through state-controlled media, is the main gatekeeper of information about foreign affairs. Our analysis of narratives about the Russo-Ukrainian War circulating on the Chinese social media platform Weibo challenges this view. Comparing narratives on Weibo with 8.26 million unique news articles from 2,500 of some of the most trafficked websites in Chi...
• Image segmentation with traveling waves in an exactly solvable recurrent neural network AI翻译
  作者：Liboni, Luisa H. B.; Budzinski, Roberto C.; Busch, Alexandra N.; Lowe, Sindy; Keller, Thomas A.; Welling, Max; Muller, Lyle E.
  作者单位：Western University (University of Western Ontario); Western University (University of Western Ontario); Western University (University of Western Ontario); University of Amsterdam; University of Amsterdam
  摘要：We study image segmentation using spatiotemporal dynamics in a recurrent neural network where the state of each unit is given by a complex number. We show that this network generates sophisticated spatiotemporal dynamics that can effectively divide an image into groups according to a scene's structural characteristics. We then demonstrate a simple algorithm for object segmentation that generalizes across inputs ranging from simple geometric objects in grayscale images to natural images. Using ...
• Tungsten is utilized for lactate consumption and SCFA production by a dominant human gut microbe Eubacterium limosum AI翻译
  作者：Putumbaka, Saisuki; Schut, Gerrit J.; Thorgersen, Michael P.; Poole, Farris L.; Shao, Nana; Rodionov, Dmitry A.; Adams, Michael W. W.
  作者单位：University System of Georgia; University of Georgia; Sanford Burnham Prebys Medical Discovery Institute
  摘要：Eubacterium limosum is a dominant member of the human gut microbiome and produces short- chain fatty acids (SCFAs). These promote immune system function and inhibit inflammation, making this microbe important for human health. Lactate is a primary source of gut SCFAs but its utilization by E. limosum has not been explored. We show that E. limosum growing on lactate takes up added tungstate rather than molybdate and produces the SCFAs acetate and butyrate, but not propionate. The genes encoding...
• Income inequality and the erosion of democracy in the twenty-first century AI翻译
  作者：Rau, Eli G.; Stokes, Susan
  作者单位：Tecnologico de Monterrey; University of Chicago
  摘要：Among the most pressing problems societies face today are economic inequality and the erosion of democratic norms and institutions. In fact the two problems-inequality and democratic erosion-are linked. In a large cross-national statistical study of risk factors for democratic erosion, we establish that economic inequality is one of the strongest predictors of where and when democracy erodes. Even wealthy and longstanding democracies are vulnerable if they are highly unequal (though national w...
• MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea AI翻译
  作者：Underhill, Anna; Webb, Samuel; Grandi, Fiorella C.; Jeng, Jing - Yi; Monvel, Jacques B. de; Plion, Baptiste; Carlton, Adam J.; Amariutei, Ana E.; Voulgari, Niovi; De Faveri, Francesca; Ceriani, Federico; Mustapha, Mirna; Johnson, Stuart L.; Safieddine, Saaid; Kros, Corne J.; Marcotti, Walter
  作者单位：University of Sheffield; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Centre National de la Recherche Scientifique (CNRS); University of Sheffield; University of Sussex
  摘要：Myosin-VIIA (MYO7A) is an unconventional myosin responsible for syndromic (Usher 1B) or nonsyndromic forms of deafness in humans when mutated. In the cochlea, MYO7A is expressed in hair cells, where it is believed to act as the motor protein tensioning the mechanoelectrical transducer (MET) channels, thus setting their resting open probability (P-o). However, direct evidence for this unique role for an unconventional myosin in mature hair cells is lacking. Here, we show that MYO7A has a distin...