2025

最新文章

• Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses AI翻译
  作者：Neuman, Benjamin W.; Smart, Alexandria; Gilmer, Orian; Smyth, Redmond P.; Vaas, Josef; Boeker, Nicolai; Samborskiy, Dmitry, V; Bartenschlager, Ralf; Seitz, Stefan; Gorbalenya, Alexander E.; Caliskan, Neva; Lauber, Chris
  作者单位：Texas A&M University System; Texas A&M University College Station; Helmholtz Association; Helmholtz-Center for Infection Research; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Institut National de la Sante et de la Recherche Medicale (Inserm); Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Helmholtz Association; Helmholtz-Center for Infection Research; Lomonosov Moscow State University; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC; University of Regensburg
  摘要：Positive- strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respectively. The acquisition of a proofreading exoribonuclease (ExoN) by an ancestral nidovirus enabled crossing of the 20 kb barrier. Other factors constraining genome size variations in nidoviruses remain poorly defined. We assemble 76 genome sequences of invertebrate nidoviruses from >500.000 published transcriptome experiments and triple th...
• Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug AI翻译
  作者：Ma, Jianlong; Chen, Yang; Song, Jingmei; Ruan, Qingfeng; Li, Lianghui; Luo, Lingfei
  作者单位：Fudan University; Southwest University - China
  摘要：Aging is a complex process that affects multiple organs, and the discovery of a pharmacological approach to ameliorate aging is considered the Holy Grail of medicine. Here, we performed an N- ethyl- N- nitrosourea forward genetic screening in zebrafish and identified an accelerated aging mutant named meteor (met), harboring a mutation in the Werner syndrome RecQ- like helicase (wrn) gene. Loss of wrn leads to a short lifespan and age- related characteristics in the intestine of zebrafish embry...
• The misalignment of incentives in academic publishing and implications for journal reform AI翻译
  作者：Trueblood, Jennifer S.; Allison, David B.; Field, Sarahanne M.; Fishbach, Ayelet; Gaillard, Stefan D. M.; Gigerenzer, Gerd; Holmes, William R.; Lewandowsky, Stephan; Matzke, Dora; Murphy, Mary C.; Musslick, Sebastian; Popov, Vencislav; Roskies, Adina L.; ter Schure, Judith; Teodorescu, Andrei R.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Groningen; University of Chicago; Radboud University Nijmegen; Max Planck Society; Indiana University System; Indiana University Bloomington; University of Bristol; University of Potsdam; University of Amsterdam; Indiana University System; Indiana University Bloomington; University Osnabruck; Brown University; University of Zurich; University of California System; University of California Santa Barbara; Technion Israel Institute of Technology
  摘要：For most researchers, academic publishing serves two goals that are often misaligned-knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can also pressure scholars to maximize publication metrics. Commercial publishing companies have capitalized on the centrality of publishing to the scientific enterprises of knowledge dissemination and academic recognition to extract large profits from academia b...
• Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response AI翻译
  作者：Wang, Ting; Wang, Xiangyu; Wang, Keke; Yu, Mengyuan; Bai, Ruihua; Zhang, Yiru; Zhang, Zihan; Liu, Feifei; Wang, Rui; Shi, Xiaodan; Jia, Ludan; Liu, Kangdong; Li, Xiang; Jin, Guoguo; Zhao, Simin; Dong, Zigang
  作者单位：Zhengzhou University; Zhengzhou University; Zhengzhou University; Zhengzhou University; Zhengzhou University
  摘要：Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol metabolism significantly promotes esophageal carcinogenesis under chronic stress conditions. Our findings indicate that the persistent elevation of glucocorticoids induced by chronic stress stimulate...
• Valuing the benefits of reducing firearm violence in the United States AI翻译
  作者：Cook, Philip J.; Jeuland, Marc; Ludwig, Jens
  作者单位：Duke University; Duke University; University of Chicago
  摘要：Justifying a proposed government regulation intended to reduce firearm violence requires a conceptually sound estimate of the monetized value of that impact and how that value is distributed across the population. Some previous estimates do not serve as a valid basis for policy evaluation or are out of date. A nationally representative survey was conducted by the AP-NORC Center for Public Affairs Research in August 2022 (n = 660). The authors designed and added a series of contingent- valuatio...
• Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity AI翻译
  作者：Isaksson, Hanna; Lind, Peter; Libby, Eric
  作者单位：Umea University; Umea University; Umea University; Umea University
  摘要：Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is unknown if continued exposure to those same selective pressures will result in the evolution of increased multicellular complexity. We use mathematical models to consider the ada...
• Reply to van Schie et al.: ARK2N in TCR: Across in vivo and in vitro studies AI翻译
  作者：Luo, Yefei; Li, Jia; Wang, Jiadong
  作者单位：Peking University
• Gesture counteracts gender stereotypes conveyed through subtle linguistic cues AI翻译
  作者：Qian, Yihan; Goldin, Susan; Bian, Lin
  作者单位：University of Chicago
  摘要：Despite increased attempts to express equality in speech, biases often leak out through subtle linguistic cues. For example, the subject-complement statement (SCS, Girls are as good as boys at math) is used to advocate for equality but often reinforces gender stereotypes (boys are the standard against which girls are judged). We ask whether stereotypes conveyed by SCS can be counteracted by gesture. Two preregistered studies with 8- to 11- y- old children (N = 320 total) investigate whether an...
• Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase ( vol 121, e2401981121, 2024) AI翻译
  作者：Toubdji, Sabrine; Thullier, Quentin; Kilz, Lea- Marie; Marchand, Virginie; Yuan, Yifeng; Sudol, Claudia; Goyenvalle, Catherine; Jean-Jean, Olivier; Rose, Simon; Douthwaite, Stephen; Hardy, Leo; Baharoglu, Zeynep; de Crecy-Lagard, Valerie; Helm, Mark; Motorin, Yuri; Hamdane, Djemel; Bregeon, Damien
• The population dynamics of clustered consumer-resource spatial patterns: Insights from the demographics of a Turing mechanism AI翻译
  作者：Hajian-Forooshani, Zachary; Rivera-Salinas, Iris Saraeny; Perfecto, Ivette; Vandermeer, John
  作者单位：University of Michigan System; University of Michigan; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Martin Luther University Halle Wittenberg; University of Michigan System; University of Michigan
  摘要：In ecology, Alan Turing's proposed activation-inhibition mechanism has been abstracted as corresponding to several ecological interaction types to explain pattern formation ecosystems. Consumer-resource interactions have strong theoretical arguments linking them to both the Turing mechanism and pattern formation, but there is little empirical support to demonstrate these claims. Here, we connect several lines of evidence to support the proposition that consumer-resource interactions can create...