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作者：Mishol, Nadav; Herzlinger, Gadi; Rak, Yoel; Smilanksy, Uzy; Carmel, Liran; Gokhman, David
作者单位：Weizmann Institute of Science; Hebrew University of Jerusalem; University of Haifa; Hebrew University of Jerusalem; Weizmann Institute of Science; Tel Aviv University; Sackler Faculty of Medicine
摘要：Denisovans are an extinct group of humans whose morphology is mostly unknown. The scarcity of verified Denisovan fossils makes it challenging to study their anatomy, and how well they were adapted to their environment. We previously developed a genetic phenotyping approach to gain insight into Denisovan anatomy by detecting gene regulatory changes that likely altered Denisovan skeletal morphology. Here, we scan the Middle Pleistocene fossil record for crania matching the predicted Denisovan mo...
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作者：Rice, Amy; Zourou, Andriana C.; Cotten, Myriam L.; Pastor, Richard W.
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Oregon State University
摘要：Membrane active peptides (MAPs) represent a diverse group of agents that disrupt the integrity of lipid membranes. One class of MAPs, antimicrobial peptides (AMPs), destroy bacteria by transiently porating the bacterial membrane causing leakage of cellular contents. Transient leakage is classified as graded, where all vesicles in a population leak partially, or all-or-none, where some vesicles leak completely. However, the molecular interactions underlying transient leakage have eluded experim...
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作者：Clark, Meaghan I.; Hileman, Eric T.; Moore, Jennifer A.; Faust, Lisa J.; Junge, Randall E.; Reid, Brendan N.; Bradke, Danielle R.; Bradburd, Gideon S.; Fitzpatrick, Sarah W.
作者单位：Michigan State University; Michigan State University; Michigan State University; University of California System; University of California Santa Cruz; West Virginia University; Grand Valley State University; Rutgers University System; Rutgers University New Brunswick; University of Namur; University System of Georgia; University of Georgia; University of Michigan System; University of Michigan
摘要：Small and fragmented populations are at high risk of local extinction, in part because of elevated inbreeding and subsequent inbreeding depression. A major conservation priority is to identify the mechanisms and extent of inbreeding depression in small populations. The eastern massasauga (Sistrurus catenatus) rattlesnake is listed as Federally Threatened in the United States, having experienced significant habitat fragmentation and concomitant population declines over the past 200 years. Here,...
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作者：Fang, Guocheng; Tseng, Po- Hao; Liao, Jie; Zhu, Song; Zhou, Tian; Liu, Hangrui; Zhu, Hui; Jin, Dayong; Yang, Lan; Chen, Yu-Cheng
作者单位：University of Technology Sydney; Nanyang Technological University; Washington University (WUSTL); University of California System; University of California San Francisco; University of Technology Sydney
摘要：Water droplets, acting as natural bioreactors and optical whispering- gallery- mode ous droplet lasers can only survive in air with a limited lifespan (<100 s) due to rapid evaporation, restricting their applications in bioreactions. To address this challenge, we introduce laser- emitting aqueous bioreactors (LEABs) in fluorocarbon oils. These LEABs enable stable laser emission and extend a droplet lifespan over 1,000- fold. LEABs enable the encapsulation of bioactive materials for long- term ...
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作者：Nelson, Rachel S.; Grossman, Margaret G.; Klug, Zasu M.; Calamari, Mia; Donayre, Alvaro; Cybulski, Thaddeus; Schooley, Jared; Griffith, Garett J.; Corcos, Daniel M.; Wright, Donald E.; Wallace, Jessica C.; Yang, Da Som; Wright Jr, John A.; Rogers, John A.; Lee, Stephen P.; Ghaffari, Roozbeh; Aranyosi, A. J.; Jain, Manu
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Northwestern University; Chung Ang University; Northwestern University; Northwestern University; Northwestern University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; Northwestern University
摘要：Sweat parameters such as volume and chloride concentration may offer invaluable clinical insights for people with CF (PwCF). Pilocarpine-induced sweat collection for chloridometry measurement is the gold standard for a CF diagnosis, but this technique is cumbersome and not suitable for remote settings or repeat measurements. We have previously reported the utility of a skin-interfaced microfluidic device (CF Patch) in conjunction with a smartphone image processing platform that enables real-ti...
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作者：Yang, Jingrui; Xia, Longlong; Groenigen, Kees Jan van; Zhao, Xu; Ti, Chaopu; Wang, Weilu; Du, Zhangliu; Fan, Mingsheng; Zhuang, Minghao; Smith, Pete; Lal, Rattan; Butterbach-Bahlh, Klaus; Han, Xiaori; Meng, Jun; Liu, Jia; Cai, Hongguang; Cheng, Yanhong; Liu, Xingren; Shu, Xiangyang; Jiao, Xiaoyan; Pan, Zhandong; Tang, Guangmu; Yan, Xiaoyuan
作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Exeter; Yangzhou University; Yangzhou University; China Agricultural University; University of Aberdeen; University System of Ohio; Ohio State University; Aarhus University; Helmholtz Association; Karlsruhe Institute of Technology; Shenyang Agricultural University; Jiangxi Academy of Agricultural Sciences; Jilin Academy of Agricultural Sciences; Chinese Academy of Agricultural Sciences; Institute of Environment & Sustainable Development in Agriculture, CAAS; Sichuan Normal University; Shanxi Agricultural University; Gansu Agricultural University; Xinjiang Academy of Agricultural Sciences
摘要：Biochar application offers significant potential to enhance food security and mitigate climate change. However, most evidence stems from short-term field experiments (<= 3 y), leaving uncertainty about the long-term sustainability of these benefits, especially with annual biochar additions to soils. To address this knowledge gap, we analyzed a global dataset from 438 studies (3,229 observations) and found that long-term annual biochar application (>= 4 y) not only sustains but often enhances i...
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作者：Dent, Matthew R.; DeMartino, Anthony W.; Xu, Qinzi; Chen, Xiukai; Gandhi, Alay; Hwang, Hyon S.; Bocian, Kaitlin A.; Correnti, Jacob E.; Abdelghany, Youmna; Alipour, Elmira; Ucer, K. Burak; Baker, Stephen R.; Kandada, Ajay Ram Srimath; Bulbul, Angka; Kim-Shapiro, Daniel B.; Rose, Jason J.; Tejero, Jesus; Gladwin, Mark T.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University System of Maryland; University of Maryland Baltimore; Wake Forest University; Wake Forest University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
摘要：Carbon monoxide (CO) poisoning causes 50,000 to 100,000 emergency department visits and similar to 1,500 deaths in the United States annually. Current treatments are limited to supplemental and/or hyperbaric oxygen to accelerate CO elimination. Even with oxygen therapy, nearly half of CO poisoning survivors suffer long-term cardiac and neurocognitive deficits related to slow CO clearance, highlighting a need for point of care antidotal therapies. Given the natural interaction between CO and fe...
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作者：Mellya, Ronald. V. K.; Hopcraft, J. Grant C.; Mwakilema, William; Eblate, Ernest M.; Mduma, Simon; Mnaya, Bakari; Chuma, Idrissa S.; Macha, Emmanuel S.; Wambura, Dickson; Fyumagwa, Robert D.; Kilbride, Elizabeth; Ijaz, Umer Z.; Mable, Barbara K.; Khan, Anubhab
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作者：Wu, Tong; Yang, Xinyu; Jin, Xueqin; Yan, Nieng; Li, Zhangqiang
作者单位：Tsinghua University; Shenzhen Medical Academy of Research & Translation (SMART); Shenzhen Bay Laboratory
摘要：The cardiac voltage-gated sodium channel Nav1.5 is resistant to tetrodotoxin (TTXr). Here, we report a cryo-electron microscopy (cryo-EM) structure of wild-type human Nav1.5, coexpressed with the beta 1 auxiliary subunit and treated with high-concentration TTX, at 3.4 & Aring; resolution. Structural comparison reveals the molecular determinants for the distinct responses to TTX as well as beta subunits between TTXr and TTX-sensitive (TTXs) Nav channels. A conserved cation-pi interaction betwee...
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作者：Foley, Erin E. B.; Thomas, Christian L.; Kyriacou, Charalambos P.; Mallon, Eamonn B.
作者单位：University of Leicester
摘要：Epigenetic clocks based on DNA methylation provide robust biomarkers of biological age, yet the mechanistic basis and functional significance of slowing these clocks remain unclear. Progress has been limited by the lack of short-lived, genetically tractable model organisms with functional DNA methylation systems. The jewel wasp, Nasonia vitripennis, offers a unique solution. It combines a functional DNA methylation system with a short lifespan and established tools for experimental manipulatio...
