2025

最新文章

• VOC injection into a house reveals large surface reservoir sizes in an indoor environment AI翻译
  作者：Yu, Jie; Lakey, Pascale S. J.; Ditto, Jenna C.; Huynh, Han N.; Link, Michael F.; Poppendieck, Dustin; Zimmerman, Stephen M.; Wang, Xing; Farmer, Delphine K.; Vance, Marina E.; Abbatt, Jonathan P. D.; Shiraiwa, Manabu
  作者单位：University of Toronto; University of California System; University of California Irvine; Washington University (WUSTL); University of Colorado System; University of Colorado Boulder; National Oceanic Atmospheric Admin (NOAA) - USA; National Institute of Standards & Technology (NIST) - USA; University of Toronto; Colorado State University System; Colorado State University Fort Collins; University of Colorado System; University of Colorado Boulder
  摘要：The total partitioning capacity of indoor surface reservoirs determines the mechanism by which humans receive nondietary exposure to organic contaminants, via inhalation, dermal uptake, and dust ingestion. And yet, this capacity is largely unknown. Surface organic films are ubiquitously present but have very low partitioning volume being only 10's of nanometer thick, whereas other surface reservoirs such as building materials and furnishings can be permeable or porous with large surface areas ...
• Virion proteomics of genetically intact HCMV reveals a regulator of envelope glycoprotein composition that protects against humoral immunity AI翻译
  作者：Bentley, Kirsten; Statkute, Evelina; Murrell, Isa; Fielding, Ceri A.; Antrobus, Robin; Preston, Hannah; Jones, Lauren Kerr -; Cochrane, Daniel; Brizic, Ilija; Lehner, Paul J.; Wilkinson, Gavin W. G.; Wang, Eddie C. Y.; Graham, Stephen C.; Weekes, Michael P.; Stanton, Richard J.
  作者单位：University of Cambridge; University of Rijeka; University of Cambridge; University of Cambridge
  摘要：Human cytomegalovirus (HCMV) is a clinically important herpesvirus that has coevolved for millions of years with its human host, and establishes lifelong persistent infection. A substantial proportion of its 235 kb genome is dedicated to manipulating host immunity through targeting antiviral host proteins for degradation or relocalization. Quantitative proteomics of the infected cell has extensively characterized these processes, but the cell-free virion has been less well studied. We therefor...
• Lymphatic dysfunction is linked to disease pathogenesis in Duchenne muscular dystrophy animal models AI翻译
  作者：Subramanian, Bhuvaneshwaran; Johnson, Shedreanna; Narayanan, Akshaya; Wang, Wei; Seaberg, Bonnie L.; Ball, Jillian; Mares, Ilse M. Paredes; Majumder, Ahana; Aceves, Alexandria; Frazier, Sarah E.; Rutledge, Alexis; Griffin, John F.; Pal, Soumiya; Zawieja, Scott; Davis, Michael J.; Rutkowski, Joseph M.; Nghiem, Peter P.; Rimer, Mendell; Muthuchamy, Mariappan
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; University of Missouri System; University of Missouri Columbia
  摘要：Duchenne muscular dystrophy (DMD) is a severe muscle-wasting disorder characterized by progressive muscle weakness and inflammation caused by mutations in the DMD gene. Chronic inflammation in DMD exacerbates the complications associated with disease progression. Since the lymphatic system plays a crucial role in regulating and resolving inflammation, our primary goal was to investigate whether lymphatics were dysregulated in skeletal muscle of DMD animals. We used the D2.mdx murine and golden...
• Large-scale surveys of woodrats (Neotoma spp.) reveal constraints on diet breadth in herbivorous mammals AI翻译
  作者：Weinstein, Sara B.; Klure, Dylan M.; Symeonidi, Efthymia; Greenhalgh, Robert; Mayes, Marc T.; Doolin, Margaret L.; Stapleton, Tess E.; Swei, Andrea; Cove, Michael, V; Dearing, M. Denise
  作者单位：Utah System of Higher Education; Utah State University; Utah System of Higher Education; University of Utah; Utah System of Higher Education; Utah State University; California State University System; San Francisco State University
  摘要：Characterizing niche space is critical for predicting species interactions and responses to environmental change. To enhance our understanding of dietary niche breadth, we used DNA metabarcoding to examine how diets of a widespread, model herbivore (wood-rats, genus Neotoma) respond to changing resources and the extent to which dietary specialization is conserved across space and time. We used diet data from 13 species, 57 populations, and over 500 individuals to examine predictors of niche br...
• Learning stochastic processes with intrinsic noise from cross-sectional biological data AI翻译
  作者：Maddu, Suryanarayana; Chardes, Victor; Shelley, Michael J.
  作者单位：Simons Foundation; Flatiron Institute; New York University
  摘要：Inferring dynamical models from data continues to be a significant challenge in computational biology, especially given the stochastic nature of many biological processes. We explore a common scenario in omics, where statistically independent cross-sectional samples are available at a few time points, and the goal is to infer the underlying diffusion process that generated the data. Existing inference approaches often simplify or ignore noise intrinsic to the system, compromising accuracy for ...
• CpG-A induces liquid-liquid phase separation of HMGB1 to activate the RAGE-mediated inflammatory pathway AI翻译
  作者：Peng, Kaihui; Fu, Gaohong; Chen, Long; Xie, Jiazhi; Bao, Kai; Li, Jin - Ping; Luo, Shi - Zhong
  作者单位：Beijing University of Chemical Technology; Uppsala University; Beijing University of Chemical Technology
  摘要：High-mobility group box protein 1 (HMGB1) is a chromatin-associated nonhistone protein widely distributed in the nucleus of eukaryotic cells. It is transported extracellularly as a proinflammatory mediator or late warning protein to induce immune and inflammatory reactions upon stimuli such as microbial infection. Here, we have found that HMGB1 directly interacts with bacterial DNA analogue CpG-A in the extracellular environment to undergo liquid-liquid phase separation (LLPS) via its positive...
• Structural basis for Rad54-and Hed1-mediated regulation of Rad51 during the transition from mitotic to meiotic recombination AI翻译
  作者：Shin, Yeonoh; Petassi, Michael T.; Jessop, Aidan M.; Kim, Stefan Y.; Matei, Razvan; Morse, Katherine; Raina, Vivek B.; Roy, Upasana; Greene, Eric C.
  作者单位：New York University; Columbia University; NewYork-Presbyterian Hospital
  摘要：Rad51 catalyzes the DNA pairing reactions that take place during homologous recombination (HR), and HR must be tightly regulated to ensure physiologically appropriate outcomes. Rad54 is an ATP- dependent DNA motor protein that stimulates Rad51 activity during mitosis. In meiosis Rad51 is downregulated by the protein Hed1, which blocks Rad54 binding to Rad51, and allows Dmc1 to function as the active recombinase. We currently have a poor understanding of the regulatory interplay between Rad54, ...
• Wild, scenic, and toxic: Recent degradation of an iconic Arctic watershed with permafrost thaw AI翻译
  作者：Sullivan, Patrick F.; Dial, Roman J.; Cooper, David J.; Diamond, Charles; Tino, Christopher J.; Gregory, Daniel D.; Wong, Russell E.; Lyons, Timothy W.
  作者单位：University of Alaska System; University of Alaska Anchorage; Alaska Pacific University; University of California System; University of California Riverside; University of Toronto
  摘要：The streams of Alaska's Brooks Range lie within a vast (similar to 14M ha) tract of protected wilderness and have long supported both resident and anadromous fish. However, dozens of historically clear streams have recently turned orange and turbid. Thawing permafrost is thought to have exposed sulfide minerals to weathering, delivering iron and other potentially toxic metals to aquatic ecosystems. Here, we report stream water metal concentrations throughout the federally designated Wild and S...
• Subaerial oxidative uranium mobilization at the culmination of the Great Oxidation Event AI翻译
  作者：Bauer, Ann M.; Li, Weiqiang; Rybacki, Kyle S.; Roden, Eric E.; Kump, Lee R.; Johnson, Clark M.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; National Aeronautics & Space Administration (NASA); Nanjing University; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
  摘要：Redox-sensitive elements figure prominently in studies of the evolution of Earth's surface redox state, including the first major rise in atmospheric O-2, the Paleoproterozoic Great Oxidation Event. Most Precambrian rocks endured multistage tectonothermal histories, however, adding ambiguity to interpretation of their chemistry. Here, we apply U-Th-Pb isotope geochronology to the highly oxidized similar to 2.06 Ga Kuetsjarvi Volcanic Formation, Pechenga Greenstone Belt, Russia, to constrain th...
• G-quadruplexes as a source of vulnerability in BRCA2-deficient granule cell progenitors and medulloblastoma AI翻译
  作者：Keahi, Danielle L.; Sanders, Mathijs A.; Paul, Matthew R.; Webster, Andrew L. H.; Fang, Yin; Wiley, Tom F.; Shalaby, Samer; Carroll, Thomas S.; Chandrasekharappa, Settara C.; Sandoval-Garcia, Carolina; MacMillan, Margaret L.; Wagner, John E.; Hatten, Mary E.; Smogorzewska, Agata
  作者单位：Rockefeller University; Wellcome Trust Sanger Institute; Erasmus University Rotterdam; Erasmus MC; Erasmus MC Cancer Institute; Rockefeller University; Rockefeller University; Rockefeller University; Rockefeller University; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI); University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Biallelic pathogenic variants in the essential DNA repair gene BRCA2 cause Fanconi anemia complementation group D1. Patients in this group are highly prone to develop embryonal tumors, most commonly medulloblastoma arising from the cerebellar granule cell progenitors (GCPs). GCPs undergo high proliferation in the postnatal cerebellum under Sonic Hedgehog (SHH) activation, but the type of DNA lesions that require the function of the BRCA2 to prevent tumorigenesis remains unknown. To identify su...