2025

最新文章

• Is Ockham's razor losing its edge? New perspectives on the principle of model parsimony AI翻译
  作者：Dubova, Marina; Chandramouli, Suyog; Gigerenzer, Gerd; Grunwaldf, Peter; Holmes, William; Lombrozo, Tania; Marelli, Marco; Musslick, Sebastian; Nicenboim, Bruno; Ross, Lauren N.; Shiffrin, Richard; White, Martha; Wagenmakers, Eric-Jan; Buerkner, Paul-Christian; Sloman, Sabina J.
  作者单位：Indiana University System; Indiana University Bloomington; Aalto University; University of Alberta; Leiden University; Leiden University - Excl LUMC; Princeton University; University of Milano-Bicocca; University Osnabruck; Brown University; Tilburg University; University of California System; University of California Irvine; Indiana University System; Indiana University Bloomington; University of Amsterdam; Dortmund University of Technology; University of Manchester
  摘要：The preference for simple explanations, known as the parsimony principle, has long guided the development of scientific theories, hypotheses, and models. Yet recent years have seen a number of successes in employing highly complex models for scientific inquiry (e.g., for 3D protein folding or climate forecasting). In this paper, we reexamine the parsimony principle in light of these scientific and technological advancements. We review recent developments, including the surprising benefits of m...
• No gender differences in attraction to young partners: A study of 4,500 blind dates AI翻译
  作者：Eastwick, Paul W.; Finkel, Eli J.; Meza, Eva M.; Ammerman, Kellie
  作者单位：University of California System; University of California Davis; Northwestern University; Northwestern University
  摘要：In mixed- gender couples, men are older than women on average. Scholars and laypeople presume that this arrangement reflects mirrored preferences such that men desire younger partners and women desire older partners. Nevertheless, relevant published data on in- person romantic evaluations-that is, studies where adults interact in person and report their initial attraction to each other-are nearly nonexistent. We examined the association of a partner's age with romantic desire (N = 9,084 dyadic...
• Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential AI翻译
  作者：Ferreri, Lucas M.; Seibert, Brittany; Caceres, C. Joaquin; Patatanian, Kayle; Holmes, Katie E.; Gay, L. Claire; Faccin, Flavio Cargnin; Cardenas, Matias; Carnaccini, Silvia; Shetty, Nishit; Rajao, Daniela; Koelle, Katia; Marr, Linsey C.; Perez, Daniel R.; Lowen, Anice C.
  作者单位：Emory University; University System of Georgia; University of Georgia; Virginia Polytechnic Institute & State University; Emory University
  摘要：Viral infections are characterized by dispersal from an initial site to secondary locations within the host. How the resultant spatial heterogeneity shapes within- host genetic diversity and viral evolutionary pathways is poorly understood. Here, we show that virus dispersal within and between the nasal cavity and trachea maintains diversity and is therefore conducive to adaptive evolution, whereas dispersal to the lungs gives rise to population heterogeneity. We infected ferrets either intran...
• Electrifying the brain capillary Ca2+ signal AI翻译
  作者：Navedo, Manuel F.; Nieves-Cintron, Madeline; Santana, L. Fernando
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis
• Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells AI翻译
  作者：Valverde-Mendez, Diana; Sunol, Alp M.; Bratton, Benjamin P.; Delarue, Morgan; Hofmann, Jennifer L.; Sheehan, Joseph P.; Gitai, Zemer; Holt, Liam J.; Shaevitz, Joshua W.; Zia, Roseanna N.
  作者单位：Princeton University; Princeton University; Stanford University; Princeton University; Vanderbilt University; Vanderbilt University; Universite de Toulouse; New York University
  摘要：The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial genetically encoded multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-3...
• Correction for Zioga et al., Observed carbon decoupling of subnational production insufficient for net- zero goal by 2050 AI翻译
  作者：Zioga, Maria; Kotz, Maximilian; Levermann, Anders
• Shifting equilibria in a warming boreal forest AI翻译
  作者：Magney, Troy S.; Pierrat, Zoe A.
  作者单位：University of California System; University of California Davis; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
• Spatially programmed alignment and actuation in printed liquid crystal elastomers AI翻译
  作者：Telles, Rodrigo; Kotikian, Arda; Freychet, Guillaume; Zhernenkov, Mikhail; Wasik, Patryk; Yavitt, Benjamin M.; Barrera, Jorge-Luis; Cook, Caitlyn C.; Pindak, Ronald; Davidson, Emily C.; Lewis, Jennifer A.
  作者单位：Harvard University; Harvard University; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Princeton University; CEA; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University System of Ohio; University of Cincinnati
  摘要：Liquid crystal elastomers (LCEs) exhibit reversible shape morphing behavior when cycled above their nematic-to- isotropic transition temperature. During extrusion- based 3D printing, LCE inks are subjected to coupled shear and extensional flows that can be harnessed to spatially control the alignment of their nematic director along prescribed print paths. Here, we combine experiment and modeling to elucidate the effects of ink composition, nozzle geometry, and printing parameters on director a...
• Targeted degradation of Pin1 by protein- destabilizing compounds (vol 121, e2403330121, 2024) AI翻译
  作者：Alboreggia, Giulia; Udompholkul, Parima; Rodriguez, Isaac; Blaha, Gregor; Pellecchia, Maurizio
• Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis AI翻译
  作者：Ito, Masaru; Yun, Yan; Kulkarni, Dhananjaya S.; Lee, Sunkyung; Sandhu, Sumit; Nunez, Briana; Hu, Linya; Lee, Kevin; Lim, Nelly; Hirota, Rachel M.; Prendergast, Rowan; Huang, Cynthia; Huang, Ivy; Hunter, Neil
  作者单位：Howard Hughes Medical Institute; University of California System; University of California Davis; University of California System; University of California Davis; University of Osaka; Brown University; University of California System; University of California Davis
  摘要：During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this crossover patterning results from nascent recombination sites competing to accrue a limiting pro- crossover RING- domain protein (COR) that diffuses between synapsed chromosomes. Here, we delineate the localization dynamics of three mammalian CORs in the mous...