2025

最新文章

• S-adenosylmethionine metabolism buffering is regulated by a decrease in glycine N-methyltransferase via the nuclear ubiquitin-proteasome system AI翻译
  作者：Kashio, Soshiro; Miura, Masayuki
  作者单位：University of Tokyo; Tohoku University; National Institutes of Natural Sciences (NINS) - Japan; National Institute for Basic Biology (NIBB)
  摘要：Metabolic homeostasis is essential for survival; however, many studies have focused on the fluctuations of these factors. Furthermore, while metabolic homeostasis depends on the balance between the production and consumption of metabolites, there have been limited investigations into the mechanisms regulating their consumption. S-adenosylmethionine (SAM) metabolism has diverse functions, including methylation, polyamine biosynthesis, and transsulfuration, making its regulation and control cruc...
• Genetic contributions to brain criticality and its relationship with human cognitive functions AI翻译
  作者：Xin, Yumeng; Cui, Yue; Yu, Shan; Liu, Ning
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of Automation, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Recently, extensive evidence has demonstrated that the brain operates close to a critical state, characterized by dynamic patterns known as neuronal avalanches. The critical state, reflecting the delicate balance between neural excitation and inhibition, offers numerous advantages in information processing. However, the role of genetics in shaping brain criticality is not fully understood. Whether there is any shared genetic factor influencing the critical state and cognitive functions remains...
• Conformation- specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution AI翻译
  作者：O'Leary, Kelly M.; Slezak, Tomasz; Kossiakoff, Anthony A.
  作者单位：University of Chicago; University of Chicago
  摘要：Subcellular compartmentalization is integral to the spatial regulation of mechanistic target of rapamycin (mTOR) signaling. However, the biological outputs associated with location-specific mTOR signaling events are poorly understood and challenging to decouple. Here, we engineered synthetic intracellular antibodies (intrabodies) that are capable of modulating mTOR signaling with genetically programmable spatial resolution. Epitope-directed phage display was exploited to generate high affinity...
• CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity AI翻译
  作者：Rodriguez, Marcelo M.; Chatterjee, Debashree; Guerry, Johanna; Patenaude, Anne - Marie; Cohen, Charles C. H.; Bois, Therence; Larouche, Ariane; Ferreira, Silvana R.; Bertomeu, Thierry; Aryamontri, Andrew; Zhang, Li; Mader, Sylvie; Nislow, Corey; Jean, Guillaume; Guindon, Yvan; Zahn, Astrid; Noia, Javier M. Di
  作者单位：Universite de Montreal; Institut de Recherche Clinique de Montreal (IRCM); Universite de Montreal; Universite de Montreal; Universite de Montreal; University of British Columbia; Universite de Montreal; Universite de Montreal; Universite de Montreal; Universite de Montreal; University of Vienna
  摘要：Cancer therapy is limited by resistance to standard-of-care chemotherapeutic and/or by treatment-associated toxicity. Identifying molecular mechanisms that modulate cellular toxicity is crucial for enhancing treatment efficacy. We characterize CDADC1, a vertebrate-specific orphan enzyme, as an unprecedented eukaryotic dCTP deaminase. CDADC1 catalyzes the conversion of dCTP into dUTP. While bacteria use this activity to sustain proliferation, CDADC1 evolved independently and is not required for...
• Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age- related macular degeneration pathology AI翻译
  作者：Wang, Ying; Zhang, Yi-Chen; Ding, Zi-Qin; Xu, Shi-Yao; Zhang, Ye-Ran; Zhu, Hong-Jing; Huang, Chang; Wang, Jia-Nan; Zhu, Meidong; Ji, Jiang-Dong; Yan, Biao; Liu, Qing-Huai; Chen, Xue
  作者单位：Nanjing Medical University; Fudan University; Fudan University; University of Sydney; Shanghai Jiao Tong University
  摘要：Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly. It is characterized by degeneration of the retinal pigment epithelium (RPE), which can develop into choroidal neovascularization (CNV) to cause severe and rapid vision loss. Preventing this progression might help save vision, but the exact mechanisms remain unclear. In this study, using clinical AMD samples and the gene knockout mice, we reported that the m1A eraser ALKBH3 reshaped retinal metabolism to p...
• Targeting ryanodine receptors with allopurinol and xanthine derivatives for the treatment of cardiac and musculoskeletal weakness disorders AI翻译
  作者：Miotto, Marco C.; Luna-Figueroa, Estefania; Tchagou, Carl; Bahlouli, Laith; Reiken, Steven; Dridi, Haikel; Liu, Yang; Weninger, Gunnar; Marks, Andrew R.
  作者单位：Columbia University; Columbia University
  摘要：Ryanodine receptors (RyRs) are intracellular Ca2+ channels essential for muscle contraction. Caffeine, a xanthine derivative, has been known for decades to increase muscle contraction and enhance activation of RyRs by increasing the sensitivity to Ca2+. We previously showed that xanthine, the only physiologically relevant xanthine derivative, also binds to and activates RyR2. Most xanthine derivatives and analogs are safe and widely prescribed, with the most popular being the xanthine oxidored...
• Equilibrium-gated pattern formation: How molecular dissociation thermodynamics drive emergent behavior in dissipative polymeric systems AI翻译
  作者：Bistri, Donald; Cramblitt, Anna; Arretche, Ignacio; Zhang, Conan; Cope, Reid B.; Zakoworotny, Michael; Mills, Mya G.; Koett, Luis E. Rodriguez; Chua, Lauren; Gomez-Bombarelli, Rafael; Tawfick, Sameh H.; Sottos, Nancy R.; Moore, Jeffrey S.; Geubelle, Philippe H.
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; Massachusetts Institute of Technology (MIT)
  摘要：Emergent patterns in biological systems arise through dissipative processes that balance reaction and transport phenomena, producing highly functional properties from self-regulating mechanisms. Synthetic fabrication, by contrast, often relies on user-controlled, multistep methods that lack the self-organizing capabilities of natural systems. Inspired by nature, we sought chemical systems that integrate strongly coupled reaction and transport phenomena, identifying frontal ring-opening metathe...
• Arabidopsis HOOKLESS1 acts as a histone acetyltransferase to promote cotyledon greening during seedling de-etiolation AI翻译
  作者：Peng, Yang; Peng, Tao; Chu, Yishan; Yan, Wei; Yao, Runyi; Wen, Xing; Qiu, Yuping; Wang, Meng; Xiao, Zhina; Zhang, Dan; Chen, Xiaoqian; Yin, Zhujun; Wang, Yichuan; Guo, Hongwei
  作者单位：Southern University of Science & Technology; Southern University of Science & Technology
  摘要：Greening immediately after etiolated- seedling's emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex transcriptional network that fine- tunes the biosynthesis of chlorophyll and prevents premature development of chloroplasts. In this study, we identified the Arabidopsis HOOKLESS1 (HLS1) as a key regulator of light- induced cotyledon greening. Our results demonstrated that HLS1 is essential for ...
• Empowering safer socially sensitive autonomous vehicles using human-plausible cognitive encoding AI翻译
  作者：Lu, Hongliang; Zhu, Meixin; Lu, Chao; Feng, Shuo; Wang, Xuesong; Wang, Yinhai; Yang, Hai
  作者单位：Hong Kong University of Science & Technology (Guangzhou); Hong Kong University of Science & Technology; Southeast University - China; Beijing Institute of Technology; Tsinghua University; Tongji University; University of Washington; University of Washington Seattle
  摘要：Autonomous vehicles (AVs) will soon cruise our roads as a global undertaking. Beyond completing driving tasks, AVs are expected to incorporate ethical considerations into their operation. However, a critical challenge remains. When multiple road users are involved, their impacts on AV ethical decision-making are distinct yet interrelated. Current AVs lack social sensitivity in ethical decisions, failing to enable both differentiated consideration of road users and a holistic view of their coll...
• Structural insights into the activation of the human prostaglandin E2 receptor EP1 subtype by prostaglandin E2 AI翻译
  作者：Meng, Xue; Li, Yang; Xu, Jiuyin; Wu, Kai; Hu, Wen; Wu, Canrong; Xu, H. Eric; Xu, Youwei
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; ShanghaiTech University; Shanghai Jiao Tong University; Guangzhou Medical University
  摘要：Prostaglandin E2 (PGE2) mediates diverse physiological processes through four G protein-coupled receptor subtypes (EP1-EP4). While structures of EP2, EP3, and EP4 have been determined, the structural basis for PGE2 recognition and activation of the EP1 receptor subtype has remained elusive due to its inherent instability. Here, we present the cryoelectron microscopy structure of the human EP1 receptor in complex with PGE2 and heterotrimeric Gq protein at 2.55 & Aring; resolution, completing th...