2025

最新文章

• A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells (vol 122, e2421710122, 2025) AI翻译
  作者：Qin, Gege; Shao, Xiying; Liu, Xiaolong; Xu, Jiachao; Wang, Xiaojia; Wang, Wenxi; Gao, Lu; Liang, Yuxin; Xie, Lina; Su, Dan; Yang, Hongwei; Zhou, Wei; Fan, Xiaohong
• Phased ERK responsiveness and developmental robustness regulate teleost skin morphogenesis AI翻译
  作者：Ramkumar, Nitya; Richardson, Christian; O'Brien, Makinnon; Butt, Faraz Ahmed; Park, Jieun; Chao, Anna T.; Bagnat, Michel; Poss, Kenneth D.; Di Talia, Stefano
  作者单位：Duke University; Duke University; Duke University; University of Wisconsin System; University of Wisconsin Madison; The Morgridge Institute for Research, Inc.; University of Wisconsin System; University of Wisconsin Madison; Duke University
  摘要：Elongation of the vertebrate embryonic axis necessitates rapid expansion of the epidermis to accommodate the growth of underlying tissues. Here, we generated a toolkit to visualize and quantify signaling in entire cell populations of the periderm, the outermost layer of the epidermis, in live developing zebrafish. We find that oriented cell divisions facilitate growth of the early periderm during axial elongation rather than cell addition from the basal layer. Activity levels of Extracellular ...
• State- dependent motion of a genetically encoded fluorescent biosensor AI翻译
  作者：Rosen, Paul C.; Horwitz, Samantha M.; Brooks, Daniel J.; Kim, Erica; Ambarian, Joseph A.; Waidmann, Lidia; Davis, Katherine M.; Yellen, Gary
  作者单位：Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT); Emory University
  摘要：Genetically encoded biosensors can measure biochemical properties such as small-molecule concentrations with single-cell resolution, even in vivo. Despite their utility, these sensors are black boxes: Very little is known about the structures of their low-and high-fluorescence states or what features are required to transition between them. We used LiLac, a lactate biosensor with a quantitative fluorescence-lifetime readout, as a model system to address these questions. X-ray crystal structure...
• Measuring criticism of the police in the local news media using large language models AI翻译
  作者：Crowl, Logan; Dutta, Sujan; Khudabukhsh, Ashiqur R.; Severnini, Edson; Nagin, Daniel S.
  作者单位：Carnegie Mellon University; Carnegie Mellon University; Rochester Institute of Technology; Boston College
  摘要：High-profile incidents of police violence against Black citizens over the past decade have spawned contentious debates in the United States on the role of police. This debate has played out prominently in the news media, leading to a perception that media outlets have become more critical of the police. There is currently, however, little empirical evidence supporting this perceived shift. We construct a large dataset of local news reporting on the police from 2013 to 2023 in 10 politically di...
• Small molecule enoxacin is a cancer- specific growth inhibitor that acts by enhancing TAR RNA- binding protein 2- mediated microRNA processing (vol 108, pg 4394, 2011) AI翻译
  作者：Melo, Sonia; Villanueva, Alberto; Moutinho, Catia; Davalos, Veronica; Spizzo, Riccardo; Ivan, Cristina; Rossi, Simona; Setien, Fernando; Casanovas, Oriol; Simo-Riudalbas, Laia; Carmona, Javier; Carrere, Jordi; Vidal, August; Aytes, Alvaro; Puertas, Sara; Ropero, Santiago; Kalluri, Raghu; Croce, Carlo M.; Calin, George A.; Esteller, Manel
• Protective role of parenthood on age- related brain function in mid- to late- life AI翻译
  作者：Orchard, Edwina R.; Chopra, Sidhant; Ooi, Leon Q. R.; Chen, Pansheng; An, Lijun; Jamadar, Sharna D.; Yeo, B. T. Thomas; Rutherford, Helena J. V.; Holmes, Avram J.
  作者单位：Yale University; Yale University; Rutgers University System; Rutgers University New Brunswick; Orygen, The National Centre of Excellence in Youth Mental Health; Orygen, The National Centre of Excellence in Youth Mental Health; University of Melbourne; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; Monash University; Monash University
  摘要：The experience of human parenthood is near ubiquitous and can profoundly alter one's body, mind, and environment. However, we know very little about the long- term neural effects of parenthood for parents themselves, or the implications of pregnancy and caregiving experience on the aging adult brain. Here, we investigate the link between the number of children parented and age on brain function in 19,964 females and 17,607 males from the UK Biobank. In both females and males, parenthood was po...
• Weakening AMOC reduces ocean carbon uptake and increases the social cost of carbon AI翻译
  作者：Schaumann, Felix; de Asenjo, Eduardo Alastrue
  作者单位：University of Hamburg; Max Planck Society; University of Hamburg
  摘要：A weakening of the Atlantic Meridional Overturning Circulation (AMOC) has been found to be globally beneficial by economic assessments. This result emerges because AMOC weakening would cool the Northern Hemisphere, thereby reducing expected climate damages and decreasing estimates of the global social cost of carbon dioxide (SCC). There are, however, many other impacts of AMOC weakening that are not yet taken into account. Here, we add a second impact channel by quantifying the effects of AMOC...
• Rethinking postdoc careers through the science of science AI翻译
  作者：Wu, Youyou; Feng, Kaiyun
  作者单位：University of London; University College London; UCL Institute of Education; University of London; King's College London; University of Cambridge
• Hypothalamic opsin 3 suppresses MC4R signaling and potentiates Kir7.1 to promote food consumption AI翻译
  作者：Haddad, Hala K.; Mercado-Reyes, Jonathan I.; Mustafa, E. Roman; D'Souza, Shane P.; Chung, C. Sean; Nestor, Ramses R. M.; Olinski, Lauren E.; Damonte, Valentina Martinez; Saskin, Joshua; Vemaraju, Shruti; Raingo, Jesica; Kauer, Julie A.; Lang, Richard A.; Oancea, Elena
  作者单位：Brown University; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Stanford University; University System of Ohio; University of Cincinnati
  摘要：Mammalian opsin 3 (OPN3) is a member of the opsin family of G- protein- coupled receptors with ambiguous light sensitivity. OPN3 was first identified in the brain (and named encephalopsin) and subsequently found to be expressed in other tissues. In adipocytes, OPN3 is necessary for light responses that modulate lipolysis and glucose uptake, while OPN3 in human skin melanocytes regulates pigmentation in a light- independent manner. Despite its initial discovery in the brain, OPN3 functional mec...
• Identification of AK4 and RHOC as potential oncogenes addicted by adult T cell leukemia AI翻译
  作者：Liu, Benquan; Yasunaga, Jun-ichirou; Liang, Yi; Zhou, Ruoning; Yang, Sikai; Yuan, Xiaoyi; Liu, Jie; Zuo, Xiaorui; Miura, Michi; Higuchi, Yusuke; Matsumoto, Takashi; Toyoda, Kosuke; Matsuoka, Masao; Ma, Guangyong
  作者单位：China Pharmaceutical University; Kumamoto University; Kyoto University
  摘要：Adult T cell leukemia (ATL) is a highly aggressive T cell malignancy characterized by human T cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify potential targets in ATL cells in order to develop effective targeted therapeutics. Here, we report the identification of two oncogenes, AK4 and RHOC, as target genes of miR- 455- 3p, a tumor- suppressive microRNA in ATL patients. Importantly, AK4 and RH...