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作者：Leithner, Alexander; Staufer, Oskar; Mitra, Tanmay; Liberta, Falk; Valvo, Salvatore; Kutuzov, Mikhail; Dada, Hannah; Spaeth, Jacob; Zhou, Weijie; Schiele, Felix; Reindl, Sophia; Nar, Herbert; Hoerer, Stefan; Crames, Maureen; Comeau, Stephen; Young, David; Low, Sarah; Jenkins, Edward; Davis, Simon J.; Klenerman, David; Nixon, Andrew; Pefaur, Noah; Wyatt, David; Dushek, Omer; Kasturirangan, Srinath; Dustin, Michael L.
作者单位：University of Oxford; Kennedy Institute for Rheumatology; Leibniz Association; Leibniz Institut fur Neue Materialien (INM); University of Oxford; Chinese Academy of Medical Sciences - Peking Union Medical College; Boehringer Ingelheim; University of Oxford; Boehringer Ingelheim; University of Oxford; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Oxford; University of Cambridge
摘要：Bispecific T cell engagers (TcEs) link T cell receptors to tumor-associated antigens on cancer cells, forming cytotoxic immunological synapses (IS). Close membrane-to-membrane contact (<= 13 nm) has been proposed as a key mechanism of TcE function. To investigate this and identify potential additional mechanisms, we compared four immunoglobulin G1-based (IgG1) TcE Formats (A-D) targeting CD3 epsilon and Her2, designed to create varying intermembrane distances (A < B < C < D). Small-angle X-ray...
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作者：Ducrot, Charles; Drouet, Adele; Tessier, Beatrice; Desquines, Chloe; Cloatre, Tiffany; Mazouzi, Rania-Cerine; Levet, Florian; Favereaux, Alexandre; Letellier, Mathieu; Thoumine, Olivier
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Bordeaux
摘要：Neuroligins (NLGNs) are important cell adhesion molecules mediating trans-synaptic contacts between neurons. However, the high-yield biochemical isolation and visualization of endogenous NLGNs is hampered by the lack of efficient antibodies. Thus, to reveal their subcellular distribution, binding partners, and synaptic function, NLGNs were extensively manipulated using knock-down, knock-out, or overexpression approaches, leading to controversial results. As an alternative to the manipulation o...
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作者：Luk, Tsz-Yat; Yim, Lok-Yan; Zhou, Runhong; Mo, Yufei; Huang, Huarong; Zhao, Meiqing; Dai, Jie; Lau, Thomas Tsz-Kan; Huang, Xiner; Lui, Grace Chung-Yan; Yuen, Kwok-Yung; Chan, Jasper Fuk-Woo; Cheng, Alfred Sze-Lok; Chen, Zhiwei; Chu, Hin
作者单位：University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; University of Hong Kong; University of Hong Kong; Chinese University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; University of Hong Kong
摘要：A major challenge for HIV type 1 (HIV-1) cure is the presence of viral latent reservoirs. The Shock & Kill strategy involves the combined use of latency reversal agents (LRA) and antiretroviral treatment (ART) to reactivate HIV-1 latent reservoirs, followed by elimination of infected cells. However, current LRAs are insufficient in fully reactivating the latent reservoirs. Therefore, investigation on novel HIV-1 latency regulators will be crucial to the success of HIV-1 cure research. Here, we...
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作者：Eggertsen, Taylor G.; Travers, Joshua G.; Hardy, Elizabeth J.; Wolf, Matthew J.; Mckinsey, Timothy A.; Saucerman, Jeffrey J.
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作者：Bhattacharjee, Sinjini; Gordiy, Igor; Sirohiwal, Abhishek; Pantazis, Dimitrios A.
作者单位：Max Planck Society; Indian Institute of Science (IISC) - Bangalore
摘要：Photosystem II (PSII) is a protein-pigment complex that utilizes sunlight to catalyze water oxidation and plastoquinone reduction, initiating the electron transfer (ET) cascade in oxygenic photosynthesis. The D1 and D2 proteins are the most important transmembrane subunits of PSII that bind all redox-active components involved in primary charge separation (CS) and ET. D1 is susceptible to oxidative photodamage, particularly under high light, and protection partly involves genetic regulation. C...
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作者：Zettler, Ingo; Lilleholt, Lau; Bader, Martina; Hilbig, Benjamin E.; Moshagen, Morten
作者单位：University of Copenhagen; University of Copenhagen; Ulm University
摘要：Humans differ in their levels of aversive (dark) personality traits such as egoism or psychopathy. Building upon theories suggesting that socioecological factors coshape the development of personality traits, it can be predicted that prior aversive societal conditions (ASC) (herein assessed via corruption, inequality, poverty, and violence) explain individuals' levels of aversive personality (assessed via the Dark Factor of Personality, the common core underlying all aversive traits). Results ...
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作者：Jensen, Samuel A.; Calvert, Andrea E.; Volpert, Giora; Kouri, Fotini M.; Hurley, Lisa A.; Luciano, Janina P.; Wu, Yongfei; Chalastanis, Alexandra; Futerman, Anthony H.; Stegh, Alexander H.
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作者：Wu, Min; Ma, Tieju; Zhu, Yan; Ren, Hongtao; Fu, Lu
作者单位：East China University of Science & Technology; Shanghai Jiao Tong University; International Institute for Applied Systems Analysis (IIASA); Institute of Information on Traditional Chinese Medicine, CACMS; China Academy of Chinese Medical Sciences; China Academy of Chinese Medical Sciences
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作者：Amado, Pedro; Dillinger, Cornel; Bahou, Chaimae; Gheinani, Ali Hashemi; Obrist, Dominik; Burkhard, Fiona; Ahmed, Daniel; Clavica, Francesco
作者单位：University of Bern; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Bern; University Hospital of Bern; University of Bern; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
摘要：Biofilm formation and encrustation are major issues in indwelling medical devices, such as urinary stents and catheters, as they lead to blockages and infections. Currently, to limit these effects, frequent replacements of these devices are necessary, resulting in a significant reduction in patients' quality of life and an increase in healthcare costs. To address these challenges, by leveraging recent advancements in robotics and microfluidic technologies, we envision a self-cleaning system fo...
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作者：Ojha, Shashank Kumar; Pal, Pratap; Prokhorenko, Sergei; Husain, Sajid; Ramesh, Maya; Li, Xinyan; Kang, Deokyoung; Meisenheimer, Peter; Schlom, Darrell G.; Stevenson, Paul; Caretta, Lucas; Nahas, Yousra; Han, Yimo; Martin, Lane W.; Bellaiche, Laurent; Eom, Chang-Beom; Ramesh, Ramamoorthy
作者单位：Rice University; Rice University; University of Wisconsin System; University of Wisconsin Madison; University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville; University of California System; University of California Berkeley; Cornell University; Cornell University; Leibniz Association; Leibniz Institut fur Kristallzuchtung (IKZ); Northeastern University; Brown University; Rice University; Rice University; Tel Aviv University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
摘要：Pattern formation in spin systems with continuous-rotational symmetry (CRS) provides a powerful platform to study emergent complex magnetic phases and topological defects in condensed-matter physics. However, its understanding and correlation with unconventional magnetic order along with high-resolution nanoscale imaging are challenging. Here, we employ scanning nitrogen vacancy (NV) magnetometry to unveil the morphogenesis of spin cycloids at both the local and global scales within a single f...
