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作者：Paulson, Abigail L.; Zhang, Lu; Prichard, Ashley M.; Singer, Annabelle C.
作者单位：University System of Georgia; Georgia Institute of Technology; Emory University; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); US Department of Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA Health Care System
摘要：40 Hz sensory stimulation (flicker) has emerged as a new technique to potentially mitigate pathology and improve cognition in mouse models of Alzheimer's disease (AD) pathology. However, it remains unknown how 40 Hz flicker affects neural codes essential for memory. Accordingly, we investigate the effects of 40 Hz flicker on neural representations of experience in the hippocampus of the 5XFAD mouse model of AD by recording 1,000s of neurons during a goal-directed spatial navigation task. We fi...
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作者：Gasparin, Matteo; Wang, Ruodu; Ramdas, Aaditya
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作者：Ishimoto, Naito; Wong, Joshua L. C.; He, Shan; Shirran, Sally; Wright-Paramio, Olivia; Seddon, Chloe; Singh, Nanki; Balsalobre, Carlos; Sonani, Ravi R.; Clements, Abigail; Egelman, Edward H.; Frankel, Gad; Beis, Konstantinos
作者单位：UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; Imperial College London; University of St Andrews; University of Barcelona; University of Virginia
摘要：Conjugation, the major driver of the spread of antimicrobial resistance genes, relies on a conjugation pilus for DNA transfer. Conjugative pili, such as the F-pilus, are dynamic tubular structures, composed of a polymerized pilin, that mediate the initial donor-recipient interactions, a process known as mating pair formation (MPF). IncH are low-copy-number plasmids, traditionally considered broad host range, which are found in bacteria infecting both humans and animals. The reference IncHI1 pl...
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作者：Poncet, Alexis; Le Blay, Marine; Irvine, William T. M.; Vitelli, Vincenzo; Bartolo, Denis; Guillet, Stephane
作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Universite Paris Cite; Total SA; University of Chicago; University of Chicago
摘要：When soft matter is driven out of equilibrium its constituents interact via effective interactions that escape Newton's action-reaction principle. Prominent examples include the hydrodynamic interactions between colloidal particles driven in viscous fluids, phoretic interactions between chemically active colloids, and quorum-sensing interactions in bacterial colonies. Despite a recent surge of interest in nonreciprocal physics, a fundamental question remains: do nonreciprocal interactions alte...
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作者：Charbonier, Frank; Zhu, Junqin; Slyman, Raleigh; Allan, Cole; Chaudhuri, Ovijit
作者单位：Stanford University; Stanford University
摘要：Collective migration of epithelial tissues is a critical feature of developmental morphogenesis and tissue homeostasis. Coherent motion of cell collectives requires large-scale coordination of motion and force generation and is influenced by mechanical properties of the underlying substrate. While tissue viscoelasticity is a ubiquitous feature of biological tissues, its role in mediating collective cell migration is unclear. Here, we have investigated the impact of substrate stress relaxation ...
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作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
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作者：Mueller, Paul Manuel; Miron, Gadi; Holtkamp, Martin; Meisel, Christian
作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
摘要：The brain criticality hypothesis postulates that brain dynamics are set at a phase transition where information processing is optimized. Long-range temporal correlations (TCs) characterizing the dissipation of information within a signal have been shown to be a hallmark of brain criticality. However, the experimental link between cognitive performance, criticality, and thus TCs has remained elusive due to limitations in recording length and spatial and temporal resolution. In this study, we in...
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作者：Finn, Lauren M.; Cummer, Rebecca; Castagner, Bastien; Keller, Bettina G.
作者单位：Free University of Berlin; McGill University
摘要：Allosteric proteins exhibit a functional response upon ligand binding far from the active site. Clostridioides difficile toxins use allosteric binding by the endogenous cofactor myo-inositol hexakisphosphate to orchestrate self-cleavage from within the target cell. This binding event induces a conformational shift, primarily effecting a lever-like /3-flap region, with two known orientations. We uncovered a mechanism for this allosteric transition using extensive atomistic molecular dynamics si...
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作者：Oggero, Silvia; Voisin, Mathieu - Benoit; Picco, Francesca; Huerta, Miguel A.; Cecconello, Chiara; Burgoyne, Thomas; Perretti, Mauro; Malcangio, Marzia
作者单位：University of London; King's College London; University of London; Queen Mary University London; University of Granada; University of London; University College London; Royal Brompton Hospital
摘要：Pain independent of disease activity is frequently reported by rheumatoid arthritis patients and remains undertreated. Preclinical evidence suggests that imbalance of neuroimmune proresolving interactions within dorsal root ganglia (DRG) rather than at the site of inflammation plays mechanistic roles in persistent arthritis pain. Here, we inhibited production of proresolving lipid mediators by silencing 12/15-lipoxygenase expression in CX3CR1+ monocyte/macrophages conditional knockout (cKO) mi...
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作者：Aguilar-Gomez, Sandra; Cardenas, Juan Camilo; Diaz, Ricardo Salas
作者单位：Universidad de los Andes (Colombia); University of Massachusetts System; University of Massachusetts Amherst; Dartmouth College
摘要：Recent research, focused mostly on the United States and Western Europe, shows that marginalized communities often face greater environmental degradation. However, the ethnoracial categories used in these studies may not fully capture environmental inequality in the Global South. Moving beyond conventional ethnoracial variables, this study presents findings exploring the link between skin tone and fine particulate matter (PM2.5) exposure in Colombia. By matching household geolocations from a l...
