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作者：Ryan, Allison T.; Kim, Minsoo
作者单位：University of Rochester
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作者：Wang, Junli; Sun, Xinhua; Xiong, Fei; Lapin, Dmitry; Lee, Tak; Martin-Ramirez, Sergio; Prakken, Anna; Shen, Qiaochu; Bautor, Jaqueline; Maekawa, Takaki; Parker, Jane E.
作者单位：Max Planck Society; University of Cologne; Max Planck Society; Southwest University - China; Utrecht University; Wageningen University & Research; University of Michigan System; University of Michigan
摘要：The plant immune system utilizes nucleotide-binding/leucine-rich repeat (NLR) proteins to detect pathogen virulence factors (effectors) inside host cells and transduce recognition to rapid defense. In dicotyledenous plants, pathogen activated Toll-like/interleukin-1 receptor-containing NLRs (TNLs) establish a signaling network of enhanced susceptibility 1 (EDS1)-family dimers with RPW8-type coiled-coil (CCR) domain NLRs (RNLs) to stimulate transcriptional reprogramming leading to host cell dea...
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作者：Forey, Romain; Raclot, Charlene; Pulver, Cyril; Rosspopoff, Olga; Offner, Sandra; Duc, Julien; Planet, Evarist; Martins, Filipe; Turelli, Priscilla; Trono, Didier
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+)
摘要：ZNF93 is a primate-restricted Kr & uuml;ppel-associated box zinc finger protein responsible for repressing 20-to 12-My-old L1 transposable elements. Here, we reveal that ZNF93 also regulates the key cancer driver APOBEC3B-a mutagenic enzyme linked to tumorigenesis and cancer progression. ZNF93 depletion impairs DNA synthesis, activates replication and DNA damage checkpoints, and triggers proinflammatory phenotypes. Conversely, its overexpression enhances resistance to exogenous genotoxic stres...
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作者：Qiu, Yu; Cen, Renyue
作者单位：Zhejiang University; Zhejiang University
摘要：Suppression effects of giant radio lobes from supermassive black holes on gas accretion onto galaxies in the surrounding regions are quantified using cosmological magneto-hydrodynamic simulations. With an appropriate amount of radio jet energy injected into the intergalactic medium following the formation peak of supermassive black holes at redshift two, we find that galaxies in the greater neighborhood of the jet-launching massive galaxies subsequently experience a significant reduction in th...
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作者：Zhou, Junxiang; Feng, Chihin; Sun, Yue; Noma, Kentaro; Jin, Yishi
作者单位：University of California System; University of California San Diego; Nagoya University
摘要：The microtubule (MT) cytoskeleton is essential for neuronal morphology, neurite growth, synapse formation and maintenance, as well as regulation of signal transduction. Most cells express multiple isotypes of alpha- and beta-tubulin that can coassemble into MTs. While a variety of signaling pathways regulate MT integrity and homeostasis, little is known about how tubulin isotypes interact in vivo. Here, we report a mechanism in conserved kinase DLK-1 and its downstream signal transduction, whi...
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作者：Brecier, Aurelie; Mailhos, Gaelle; Jarzebowski, Przemyslaw; Li, Yuqi; Paulsen, Ole; Hay, Y. Audrey
作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean Monnet; University of Cambridge; University of London; University College London
摘要：Non-rapid eye movement (NREM) sleep facilitates memory consolidation by transferring information from the hippocampus to the neocortex. This transfer is thought to occur primarily when hippocampal sharp-wave ripples (SWRs) and thalamocortical spindles are synchronized. However, the mechanisms underlying this synchronization remain unknown. In this study, we investigated the role of cortical layer 1 neuron-derived neurotrophic factor (NDNF)-expressing (L1 NDNF) interneurons in gating informatio...
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作者：Pallavi, Anuma; Sinha, Neha; ArunKumar, Nagapriya K.; Kothegala, Lakshmi; Gandasi, Nikhil R.
作者单位：Indian Institute of Science (IISC) - Bangalore; University of Gothenburg; Uppsala University
摘要：Glucose transporters (GLUT1/2) facilitate glucose uptake in pancreatic beta cells, triggering insulin secretion. The availability of GLUTs at the plasma membrane (PM) is governed by its expression, delivery to the membrane, and endocytosis. Little is known about the dynamics of GLUT trafficking in response to glucose that triggers glucose-stimulated insulin secretion. In our study, we found that the recruitment of GLUTs to the PM of beta cells correlates with increasing glucose concentrations....
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作者：Aslam, Sadaf; Sanchez-Aparicio, Maria T.; Siempelkamp, Braden D.; Dornan, Gillian L.; Tsolakos, Nikos; Burke, John E.; Hale, Benjamin G.; Sastre, Adolfo Garcia; Ayllon, Juan
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Universidad de Burgos; University of Victoria; University of Zurich; University of British Columbia; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being the main viral interferon antagonist. However, there are several interactions whose biological relevance remains obscure, such as the ability of NS1 to bind and activate class IA phosphoinositide 3-kinases (PI3Ks). PI3Ks are highly regulated lipid kinases that act as critical nodes in multiple cell...
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作者：Frail, Sarah; Steele-Ogus, Melissa; Doenier, Jon; Moulin, Solene L. Y.; Braukmann, Tom; Xu, Shouling; Yeh, Ellen
作者单位：Stanford University; Stanford University; Carnegie Institution for Science; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：Endosymbiotic gene transfer (EGT) and import of host-encoded proteins have been considered hallmarks of organelles necessary for stable integration of two cells. However, newer endosymbiotic models have challenged the origin and timing of such genetic integration during organellogenesis. Epithemia diatoms contain diazoplasts, obligate endosymbionts derived from cyanobacteria that are closely phylogenetically related to UCYN-A, a recently described nitrogen-fixing organelle. Diazoplasts functio...
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作者：Hudina, Esther; Schott-Verdugo, Stephan; Junglas, Benedikt; Kutzner, Mirka; Ritter, Ilona; Hellmann, Nadja; Schneider, Dirk; Gohlke, Holger; Sachse, Carsten
作者单位：Helmholtz Association; Research Center Julich; Heinrich Heine University Dusseldorf; Helmholtz Association; Research Center Julich; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz; Heinrich Heine University Dusseldorf
摘要：The phage shock protein A (PspA), a bacterial member of the endosomal sorting complexes required for transport (ESCRT)-III superfamily, forms rod-shaped helical assemblies that internalize membrane tubules. The N-terminal helix alpha 0 of PspA (and other ESCRT-III members) has been suggested to act as a membrane anchor; the detailed mechanism, however, of how it binds to membranes and eventually triggers membrane fusion and/or fission events remains unclear. By solving a total of 15 cryoelectr...
