2025

最新文章

• RNA polymerase III transcription-associated polyadenylation promotes the accumulation of noncoding retrotransposons during infection AI翻译
  作者：Lari, Azra; Shah, Sahil B.; Mao, Xiaowen; Sanghrajka, Priyanka; Karijolich, John; Lareau, Liana F.; Glaunsinger, Britt A.
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Vanderbilt University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute
  摘要：The accumulation of RNA Polymerase III (Pol III) transcribed short interspersed nuclear element (SINE) retrotransposon RNA is a hallmark of various cellular stressors, including DNA virus infection. However, the molecular mechanisms driving the induction of these normally repressed loci are largely undefined. Here, we reveal that in addition to Pol III transcriptional induction, gammaherpesvirus infection stimulates mRNA-like 3 ' end processing of SINE RNAs that leads to their stabilization. W...
• Striatal and cerebellar interactions during reward-based motor performance AI翻译
  作者：Lee, Joonhee Leo; Casamento-Moran, Agostina; Bastian, Amy J.; Cullen, Kathleen E.; Chib, Vikram S.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Kennedy Krieger Institute; Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University
  摘要：Goal-directed motor performance relies on the brain's ability to distinguish between actions that lead to successful and unsuccessful outcomes. The basal ganglia (BG) and cerebellum (CBL) are integral for processing performance outcomes, yet their functional interactions remain underexplored. We scanned participants' brains with functional magnetic imaging (fMRI) while they performed a skilled motor task for monetary rewards, where outcomes depended on their motor performance and probabilistic...
• 20E-induced Kr-h1 expression facilitates developmental transitions depending on chromosome accessibility of BR-C enhancers AI翻译
  作者：Long, Shihui; Qiu, Yongyu; Lin, Tong; Huang, Shumin; Zhang, Wenhao; Liu, Suning; Tian, Ling; Palli, Subba R.; Li, Sheng; Li, Kang
  作者单位：South China Normal University; Huaihua University; Guangdong Laboratory for Lingnan Modern Agriculture; University of Kentucky; South China Normal University
  摘要：Transcription factors and histone modification-mediated chromatin accessibility coordinately regulate spatiotemporal expression of genes that control growth and development. It is well documented that juvenile hormone-activated Kr-h1 antagonizes 20-hydroxyecdysone (20E)-induced expression of the pupal specifier BR-C to sustain larval status in holometabolous insects. Here, we revealed that during the larval-prepupal transition in Drosophila melanogaster, the 20E-activated Kr-h1-BR-C axis is a ...
• 撤稿声明: Microtubule- associated protein 1 light chain 3 alpha (LC3)- associated phagocytosis is required for the efficient clearance of dead cells AI翻译
  作者：Martinez, Jennifer; Almendinger, Johann; Oberst, Andrew; Ness, Rachel; Dillon, Christopher P.; Fitzgerald, Patrick; Hengartner, Michael O.; Green, Douglas R.
• Fluid flow generates bacterial conjugation hot spots by increasing the rate of shear-driven cell-cell encounters AI翻译
  作者：Zbinden, Matti; Huisman, Jana S.; Blitvic, Natasha; Stocker, Roman; Slomka, Jonasz
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Massachusetts Institute of Technology (MIT); University of London; Queen Mary University London
  摘要：Conjugation accelerates bacterial evolution by enabling bacteria to acquire genes horizontally from their neighbors. Plasmid donors must physically encounter and connect with recipients to allow plasmid transfer, and different environments are characterized by vastly different encounter rates between cells, based on mechanisms ranging from simple diffusion to fluid flow. However, how the environment affects the conjugation rate by setting the encounter rate has been largely neglected, mostly b...
• Genetic rescue of Florida panthers reduced homozygosity but did not swamp ancestral genotypes AI翻译
  作者：Aguilar-Gomaz, Diana; Yuan, Lin; Zhang, Yulin; Ochoa, Alexander; Culver, Melanie; Fitak, Robert R.; Onorato, Dave; Lohmueller, Kirk E.; Nielsen, Rasmus
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Berkeley; Chinese University of Hong Kong; Yale University; University of Arizona; University of Arizona; State University System of Florida; University of Central Florida; Florida Fish & Wildlife Conservation Commission; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Pumas (Puma concolor) occupy a vast geographical range spanning from Canada to Argentina. Due to urbanization and unregulated hunting, pumas in Florida, known as panthers, are the only breeding population east of the Mississippi River. In the 1990s, Florida panthers numbered <30 individuals suffering from inbreeding depression. In 1995, eight pumas from Texas were translocated into southern Florida to mitigate the effects of isolation. This translocation reduced inbreeding depression and incre...
• Data- driven equation discovery reveals nonlinear reinforcement learning in humans AI翻译
  作者：LaFollette, Kyle J.; Yuval, Janni; Schurr, Roey; Melnikoff, David; Goldenberg, Amit
  作者单位：Alphabet Inc.; Google Incorporated; University System of Ohio; Case Western Reserve University; University of Chicago; Massachusetts Institute of Technology (MIT); Harvard University; Stanford University; Harvard University; Harvard University
  摘要：Computational models of reinforcement learning (RL) have significantly contributed to our understanding of human behavior and decision- making. Traditional RL models, however, often adopt a linear approach to updating reward expectations, potentially oversimplifying the nuanced relationship between human behavior and rewards. To address these challenges and explore models of RL, we utilized a method of model discovery using equation discovery algorithms. This method, currently used mainly in p...
• Lipid residue analysis reveals divergent culinary practices in Japan and Korea at the dawn of intensive agriculture AI翻译
  作者：Craig, Oliver E.; Lundy, Jasmine; Bondetti, Manon; Nicholson-Lailey, Sesha; Murakami, Natsuki; Suzuki, Miho; Stevens, Chris; Lucquin, Alexandre; Talbot, Helen M.; Son, Joon- ho; Fujio, Shinichiro; Sakamoto, Minoru; Yamashita, Yusuke; Kobayashi, Kenichi; Crema, Enrico R.; Shoda, Shinya
  作者单位：University of York - UK; University of London; University College London; Korea University; Chuo University; University of Cambridge
  摘要：The dispersal of millet and rice agriculture from Korea to Japan from around 3,000 y ago has been well documented through radiocarbon analysis of botanical remains and surveying seed impressions on pottery. Much less is known about the extent to which these novel crops were consumed and incorporated into everyday culinary practices. In Japan, agriculturalists moving from Korea would have encountered large, sedentary Final Jomon populations who had well-established hunting, foraging, and cultiv...
• SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals AI翻译
  作者：Kataruka, Shubhangini; Malla, Aushaq B.; Rainsford, Shannon R.; Walters, Benjamin William; Heuer, Rachel A.; Marshall, Kira L.
  作者单位：Yale University; Yale University; Yale University; Yale New Haven Hospital
  摘要：Establishment of correct chromatin configuration in male meiosis is essential for sperm formation and male fertility. However, how chromatin remodeling contributes to meiotic progression in male germ cells is not well understood. Here, we find that the ISWI family ATP-dependent chromatin remodeling factor SMARCA5 (SNF2H) plays a critical role in regulating meiotic prophase progression during spermatogenesis in mice. Male mice with germ cell-specific depletion of SMARCA5 are infertile and unabl...
• BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly (vol. 102, pg. 15105, 2005) AI翻译
  作者：Lin, Shiaw-Yi; Rai, Rekha; Li, Kaiyi; Xu, Zhi-Xiang; Elledge, Stephen J.