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作者：Pellegrin, Clement; Damm, Anika; Sperling, Alexis L.; Molloy, Beth; Shin, Dio S.; Long, Jonathan; Brett, Paul; Iguh, Tochukwu Chisom; Kranse, Olaf P.; Bravo, Andrea Diaz-Tendero; Lynch, Sarah Jane; Senatori, Beatrice; Vieira, Paulo; Mejias, Joffrey; Kumar, Anil; Masonbrink, Rick E.; Maier, Tom R.; Baum, Thomas J.; van den Akker, Sebastian
作者单位：University of Cambridge; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; United States Department of Agriculture (USDA); USDA Agricultural Research Service; Iowa State University; Iowa State University
摘要：Pathogens must precisely tailor their gene expression to cause infection. However, a signaling cascade from host signal to effector production has remained elusive for metazoan pathogens. Here, we show that plants contain molecular signals, termed effectostimulins, that activate the first identified regulator of plant-parasitic nematode effectors. SUGR-1 directly binds effector promoters, and is central to a transcriptional network that activates 58 effector genes. Importantly, we demonstrate ...
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作者：Dong, Weilai; Jin, Sheng Chih; Sierant, Michael C.; Lu, Ziyu; Li, Boyang; Lu, Qiongshi; Morton, Sarah U.; Zhang, Junhui; Lopez-Giraldez, Francesc; Nelson-Williams, Carol; Knight, James R.; Zhao, Hongyu; Cao, Junyue; Mane, Shrikant; Gruber, Peter J.; Lek, Monkol; Goldmuntz, Elizabeth; Deanfield, John; Giardini, Alessandro; Mital, Seema; Russell, Mark; Gaynor, J. William; Cnota, James F.; Wagner, Michael; Srivastava, Deepak; Bernstein, Daniel; Porter Jr, George A.; Newburger, Jane; Roberts, Amy E.; Yandell, Mark; Yost, H. Joseph; Tristani-Firouzi, Martin; Kim, Richard; Seidman, Jonathan; Chung, Wendy K.; Gelb, Bruce D.; Seidman, Christine E.; Lifton, Richard P.; Brueckner, Martina
作者单位：Yale University; Rockefeller University; Washington University (WUSTL); Washington University (WUSTL); Rockefeller University; Yale University; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Yale University; Yale University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of London; University College London; University of London; University College London; Great Ormond Street Hospital for Children NHS Foundation Trust; University of Toronto; Hospital for Sick Children (SickKids); University of Michigan System; University of Michigan; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University of California System; University of California San Francisco; The J David Gladstone Institutes; Stanford University; University of Rochester; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Utah System of Higher Education; University of Utah; Catholic University of America; Utah System of Higher Education; University of Utah; Cedars Sinai Medical Center; Harvard University; Harvard Medical School; Columbia University; Columbia University; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Howard Hughes Medical Institute; Yale University
摘要：Variants with large effect contribute to congenital heart disease (CHD). To date, recessive genotypes (RGs) have commonly been implicated through anecdotal ascertainment of consanguineous families and candidate gene-based analysis; the recessive contribution to the broad range of CHD phenotypes has been limited. We analyzed whole exome sequences of 5,424 CHD probands. Rare damaging RGs were estimated to contribute to at least 2.2% of CHD, with greater enrichment among laterality phenotypes (5....
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作者：Langendorf, Ryan E.; Estes, James A.; Watson, Jane C.; Kenner, Michael C.; Hatfield, Brian B.; Tinker, M. Tim; Waddle, Ellen; DeMarcheh, Megan L.; Doak, Daniel F.
作者单位：University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; United States Department of the Interior; United States Geological Survey; University of California System; University of California Santa Cruz; Vancouver Island University; University of Colorado System; University of Colorado Boulder; University System of Georgia; University of Georgia
摘要：Sea otters are an iconic keystone predator that can maintain kelp forests by preying on grazing invertebrates such as sea urchins. However, the effects of sea otters on kelp forests vary over their geographic range. Here, we analyze two 30-y datasets on kelp forest communities during the reintroduction of sea otters along the west coast of Vancouver Island, BC, Canada, and around San Nicolas Island, CA. We developed a community model to estimate species interactions as dynamic rates, varying w...
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作者：Chen, Lang; Song, Zhe; Yao, Ningning; Xi, Huan; Li, Jian; Gao, Peng; Chen, Yulei; Su, Haoyuan; Sun, Yuhai; Jiang, Boqiong; Chen, Jianmin; Zhang, Yuanhang; Zhu, Tong; Li, Pengfei; Pang, Xiaobing; Yu, Shaocai
作者单位：Zhejiang Gongshang University; Zhejiang Gongshang University; Zhejiang University; Fudan University; Peking University; Chinese Academy of Sciences; Shanghai Institute of Technical Physics, CAS; Zhejiang University of Technology
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作者：Kim, Hyung Soon; Jee, Seung Ah; Einisadr, Ariandokht; Seo, Yeojin; Seo, Hyo Gyeong; Jang, Byeong Seong; Park, Hee Hwan; Chung, Won-Suk; Kim, Byung Gon
作者单位：Ajou University; Ajou University; Korea Advanced Institute of Science & Technology (KAIST); Institute for Basic Science - Korea (IBS); Ajou University
摘要：Poststroke inflammation critically influences functional outcomes following ischemic stroke. Arginase- 1 (Arg1) is considered a marker for anti- inflammatory macrophages, associated with the resolution of inflammation and promotion of tissue repair in various pathological conditions. However, its specific role in poststroke recovery remains to be elucidated. This study investigates the functional impact of Arg1 expressed in macrophages on poststroke recovery and inflammatory milieu. We observe...
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作者：Neumann, Oara; Ju, Yilong; Alvarado, Andres B. Sanchez -; Zhou, Guodong; Jiang, Weiwu; Moorthy, Bhagavatula; Suter, Melissa A.; Patel, Ankit; Nordlander, Peter; Halas, Naomi J.
作者单位：Rice University; Rice University; Rice University; Rice University; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Rice University
摘要：The detection and identification of polycyclic aromatic hydrocarbons (PAHs) and their derivatives, polycyclic aromatic compounds (PACs), are essential for environmental and health monitoring, for assessing toxicological exposure and their associated health risks. PAHs/PACs are the most dangerous chemicals found in tobacco smoke, and cigarette use during pregnancy can convey these molecules to the developing fetus through the placenta. This exposure is associated with many negative health outco...
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作者：Yuan, Deyu; He, Huan; Song, William; Ma, Duhan; Xie, Mingfeng; Wang, Yuchun; Wei, Jinliang; Wei, Jinliang; He, Qianyu; Bao, Yongli; Zhao, Yongyun
作者单位：Northeast Normal University - China; Sichuan University
摘要：Functions of RNAs are associated with their abundance and unique subcellular localizations. RNA imaging methods for spatiotemporal monitoring of RNA dynamics would facilitate the discovery of unknown functions of RNA, yet improving RNA imaging is challenging because of limitations in methods for directly monitoring native RNA, especially the dynamics of RNA transport and concentration fluctuation. Herein, a label- free and conformation switching-based genetically encoded sensor, termed the Dua...
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作者：Chen, Duyu; Samajdar, Rhine; Jiao, Yang; Torquato, Salvatore
作者单位：University of California System; University of California Santa Barbara; Princeton University; Princeton University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Princeton University; Princeton University
摘要：Classical spin liquids (CSLs) are intriguing states of matter that do not exhibit longrange magnetic order and are characterized by an extensive ground-state degeneracy. Adding quantum fluctuations, which induce dynamics between these different classical ground states, can give rise to quantum spin liquids (QSLs). QSLs are highly entangled quantum phases of matter characterized by fascinating emergent properties, such as fractionalized excitations and topological order. One such exotic quantum...
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作者：Doruska, Molly J.; Barrett, Christopher B.; Rohr, Jason R.
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作者：Shibata, Kengo; Chen, Cheng; Tai, Xin You; Manohar, Sanjay G.; Husain, Masud
作者单位：University of Oxford; University of Oxford; Oxford University Hospitals NHS Foundation Trust; University of Oxford
摘要：The effects of apolipoprotein E (APOE) and Klotho genes, both implicated in aging, on human cognition as a function of sex and age are yet to be definitively established. Here, we showed in the largest cohort studied to date (N = 320,861) that APOE homozygous epsilon 4 carriers had a greater decline in cognition with aging compared to epsilon 3 carriers (epsilon 3/epsilon 4 and epsilon 3/epsilon 3) as well as smaller hippocampi and amygdala (N = 29,510). Critically, sex and age differentially ...
