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作者：Radic, Laura; Offersgaard, Anna; Kadava, Tereza; Zon, Ian; Capella-Pujol, Joan; Mulder, Fabian; Koekkoek, Sylvie; Spek, Vera; Chumbe, Ana; Bukh, Jens; van Gils, Marit J.; Sanders, Rogier W.; Yin, Victor C.; Heck, Albert J. R.; Gottwein, Judith M.; Sliepen, Kwinten; Schinkel, Janke
作者单位：University of Amsterdam; University of Copenhagen; University of Copenhagen; Utrecht University; Utrecht University; Cornell University; Weill Cornell Medicine
摘要：Hepatitis C virus (HCV) currently causes about one million infections and 240,000 deaths worldwide each year. To reach the goal set by the World Health Organization of global HCV elimination by 2030, it is critical to develop a prophylactic vaccine. Broadly neutralizing antibodies (bNAbs) target the E1E2 envelope glycoproteins on the viral surface, can neutralize a broad range of the highly diverse circulating HCV strains, and are essential tools to inform vaccine design. However, bNAbs target...
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作者：Fan, Xinqi; Zhou, Yingjun; Bai, Wenjuan; Li, Xue; Lin, Liyuan; Lin, Huibin; Yang, Ming; Yu, Xiaofei; Wang, Jing; Lin, Liang; Wang, Wei
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Jiao Tong University
摘要：The translocation of bacteria from intestinal tracts into blood vessels and distal organs plays pivotal roles in the pathogenesis of numerous severe diseases. Intravital monitoring of bacterial translocation, however, is not yet feasible, which greatly hinders us from comprehending this spatially and temporally dynamic process. Here we report an in vivo fluorogenic labeling method, which enables in situ imaging of mouse gut microbiota and real- time tracking of the translocated bacteria. By mi...
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作者：Magesh, Shruthi; Schrope, Jonathan H.; Soto, Nayanna Mercado; Li, Chao; Hurley, Amanda I.; Huttenlocher, Anna; Beebe, David J.; Handelsman, Jo
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作者：Pelz, Setu; Ganti, Gaurav; Lamboll, Robin; Grant, Luke; Smith, Chris; Pachauri, Shonali; Rogelj, Joeri; Riahi, Keywan; Thiery, Wim; Gidden, Matthew J.
作者单位：International Institute for Applied Systems Analysis (IIASA); Humboldt University of Berlin; Imperial College London; Imperial College London; Vrije Universiteit Brussel
摘要：Current emissions trends will likely deplete a 1.5 degrees C consistent carbon budget around the year 2030, resulting in at least a temporary exceedance, or overshoot. To clarify responsibilities for this budget exceedance, we consider net- zero carbon debt, a forward- looking measure of the extent to which a party is expected to breach its fair share of the remaining budget by the time it achieves net- zero carbon emissions. We apply this measure to all vetted mitigation scenarios assessed in...
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作者：Jeon, Juwan; Roda, Mar Simonet; Chen, Zhong-Yang; Luo, Cui; Kershaw, Stephen; Kim, Daeyeong; Ma, Jun-Ye; Lee, Jeong- Hyun; Zhang, Yuan-Dong
作者单位：Korea University; Chinese Academy of Sciences; Institute for Basic Science - Korea (IBS); Korea University; Chungnam National University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Brunel University; Natural History Museum London; Korea Polar Research Institute (KOPRI); Chungnam National University
摘要：Stromatoporoid sponges were important reef-builders during the middle Paleozoic, yet their early history and integration into reef ecosystems remain poorly understood. Here, we report Lophiostroma leizunia Jeon sp. nov., the oldest known stromatoporoid from upper Tremadocian to lower Floian (similar to 480 My-old) strata of South China. L. leizunia formed complex reef structures, playing crucial roles in framework construction and binding other components, including calcimicrobes, lithistid sp...
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作者：Bednarek, Angela T.; Miyamoto, Ben; Corbett, Kristin; Hudson, Charlotte; Scarrow, Gayle; Brass, Maeghan; DuMont, Kim; Holmes, Bev; Supplee, Lauren; McLean, Robert; Bhatia, Jaspal; Chappell, Shamira; Velez, Maggie Gorman; Kolavalli, Chhaya
作者单位：National Oceanic Atmospheric Admin (NOAA) - USA; University of Michigan System; University of Michigan
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作者：Chen, Guangbo; Mohsin, Azam; Zheng, Hong; Rosenberg -Hasson, Yael; Padilla, Cindy; Sarin, Kavita Y.; Dekker, Cornelia L.; Grant, Philip; Maecker, Holden T.; Lu, Ying; Furman, David; Orr, Shai; Khatri, Purvesh; Davis, Mark M.
作者单位：Medical College of Wisconsin; Medical College of Wisconsin; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Buck Institute for Research on Aging; Stanford University; University of Southern California; Technion Israel Institute of Technology; Rappaport Faculty of Medicine
摘要：Aging is associated with increased variability and dysregulation of the immune system. We performed a system-level analysis of serum cytokines in a longitudinal cohort of 133 healthy individuals over 9 y. We found that cancer incidence is a major contributor to increased cytokine abundance variability. Circulating cytokines increase up to 4 y before a cancer diagnosis in subjects with age over 80 y. We also analyzed cytokine expression in 10 types of early-stage cancers from The Cancer Genome ...
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作者：Magrinya, Paula; Palacios-Alonso, Pablo; Llombart, Pablo; Delgado-Buscalioni, Rafael; Alexander-Katz, Alfredo; Arriaga, Laura R.; Aragones, Juan L.
作者单位：Autonomous University of Madrid; Massachusetts Institute of Technology (MIT)
摘要：Friction forces are essential for cell movement, yet they also trigger numerous active cellular responses, complicating their measurement in vivo. Here, we introduce a synthetic model designed to measure friction forces between biomimetic membranes and substrates. The model consists of a vesicle with precisely controlled properties, fabricated via microfluidics, encapsulating a single ferromagnetic particle that is magnetically driven to rotate. The rotation of the particle generates a confine...
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作者：Zhang, Wei; Li, Wenming; Du, Jun; Yang, Chen; Yu, Lei; Yang, Peng; Zhang, Haifeng; Wu, Zebin; Ge, Gaoran; Yang, Huilin; Geng, Dechun
作者单位：Soochow University - China; Yangzhou University; Shanghai Jiao Tong University
摘要：Redox imbalance contributes to aberrant osteoclastogenesis and osteoporotic bone loss. In this study, we observed lower Forkhead box protein O3 (FoxO3), a transcription factor associated with cellular oxidative stress, enhanced osteoclastogenesis in osteoporosis (OP). Single-cell RNA sequencing (scRNA-seq) analysis on the human femoral head indicated that FoxO3 is widely expressed in macrophages. Furthermore, Lysm-Cre;FoxO3f/f OVX mice showed increased reactive oxygen species (ROS), enhanced o...
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作者：Das, Saikat; Reza, Seyednejad Seyed; Copar, Simon; Dhara, Surajit
作者单位：University of Hyderabad; University of Ljubljana
摘要：In emulsions of multicomponent fluids, the dispersed phase forms tiny droplets in the continuous phase. In situ control and manipulation to achieve diversity in emulsion droplets for emerging applications is challenging. In a liquid crystal-based emulsion, the surface anchoring of the molecules at the isotropic fluid-liquid crystal interface introduces elastic distortions that result in anisotropic interparticle interactions, similar to electrostatic interactions between multipoles, which also...
