Proceedings of the National Academy of Sciences of the United States of America

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• Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling (vol 122, e2501635122, 2025) AI翻译
  作者：Ota, Naruhisa; Davies, Christopher W.; Kang, Jing; Yan, Donghong; Scherl, Alexis; Wong, Anne; Cook, Ryan; Tao, Xun; Dunlap, Debra; Klabunde, Sha; Mantik, Priscilla; Mohanan, Vishnu; Lin, WeiYu; McBride, Jacqueline; Sadekar, Shraddha; Storek, Kelly M.; Lupardus, Patrick; Ye, Zhengmao; Wallweber, Heidi Ackerly; Kiefer, James R.; Xu, Min; Chan, Pamela; Nagapudi, Karthik; Yi, Tangsheng; Koerber, James T.
• Supporting Information for Rei et al., Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway ( vol 112 , pg 7291-7296 , 2015 ) AI翻译
  作者：Rei, Damien; Mason, Xenos; Seo, Jinsoo; Rudenko, Andrii; Wang, Jun; Rueda, Richard; Siegert, Sandra; Cho, Sukhee; Canter, Rebecca G.; Mungenast, Alison E.; Deisseroth, Karl; Tsai, Li - Huei
• A twisted chromophore powers a turn- on fluorescent protein chloride sensor AI翻译
  作者：Chen, Cheng; Pathiranage, Vishaka; Ong, Whitney S. Y.; Dodani, Sheel C.; Walker, Alice R.; Fang, Chong
  作者单位：Oregon State University; Wayne State University; University of Texas System; University of Texas Dallas
  摘要：Fluorescent proteins (FPs) are noninvasive genetically encodable probes that have revolutionized bioimaging and health fields with vivid images and an ever-growing repertoire from jellyfish to sea anemones and corals. Inside the protein matrix, chromophore non-planarity and flexibility have long been argued to govern the fluorescence efficiency of FPs, yet their fundamental roles and relative importance have been elusive which hinder the rational design of versatile FPs and biosensors. Herein,...
• 撤稿声明: A bifunctional tRNA import receptor from Leishmania mitochondria AI翻译
  作者：Goswami, Srikanta; Dhar, Gunjan; Mukherjee, Saikat; Mahata, Bidesh; Chatterjee, Saibal; Home, Pratik; Adhya, Samit
• Threonine phosphorylation of STAT1 safeguards gut epithelial and restricts interferon-mediated AI翻译
  作者：Metwally, Hozaifa; Elbrashy, Maha M.; Kayama, Hisako; Okuyama, Kazuki; Taniuchi, Ichiro; Takeda, Kiyoshi; Kishimoto, Tadamitsu
  作者单位：University of Osaka; Egyptian Knowledge Bank (EKB); National Research Centre (NRC); University of Osaka; University of Osaka; RIKEN
  摘要：Barrier tissues such as the intestine are constantly challenged by environmental stressors and must adapt to maintain integrity and prevent excessive inflammation. Although traditionally viewed as a proinflammatory effector of interferon (IFN) signaling, STAT1 is shown here to play a protective role in intestinal epithelial cells (IEC) by promoting resilience to damage and restraining IFN- induced cytotoxicity. We identify phosphorylation of threonine 748 (Thr748) on STAT1 as an evolutionarily...
• A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo AI翻译
  作者：Ridelfi, Matteo; Vezzani, Giacomo; Roscioli, Emanuele; Batani, Giampiero; Boero, Elena; Nannini, Francesco; Marini, Eleonora; Bhaumik, Ushasi; Desalegn, Girmay; Serpino, Ornella; Molinaro, Antonio; Paciello, Ida; Mugnaini, Chiara; De Santi, Concetta; Maccari, Giuseppe; De Rosa, Antonella; Valensin, Silvia; Duatti, Assia; Di Benedetto, Roberta; Raso, Maria Michelina; Alfini, Renzo; Sammicheli, Chiara; Tavarini, Simona; Quigley, Christina; Podda, Audino; Kabanova, Anna; Andreano, Emanuele; Cardamone, Dario; Gasperini, Gianmarco; Necchi, Francesca; Pizza, Mariagrazia; Martin, Laura B.; Frenck Jr, Robert W.; Grassart, Alexandre; Silipo, Alba; Pasetti, Marcela F.; Scorza, Francesco Berlanda; Giannelli, Carlo; Rossi, Omar; Micoli, Francesca; Sala, Claudia; Rappuoli, Rino
  作者单位：University of Siena; GlaxoSmithKline; University System of Maryland; University of Maryland Baltimore; University of Naples Federico II; GlaxoSmithKline; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Pasteur Network; Universite de Lille; Institut Pasteur Lille; Imperial College London; United States Pharmacopeia (USP)
  摘要：Shigellosis is a global public health challenge that mostly affects low-and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi-and extensively drug-resistant Shigella sonnei strains associated with recent outbreaks in high-income countries exacerbate the problem and have prompted the World Health Organization to include Shigella spp. among the high-risk pathogens for which novel prophylactic and therapeutic tools are urgently needed. ...
• mtKO: A dedicated guide RNA library for mitochondria research AI翻译
  作者：Kaur, Karambir; Zaheer, Javeria; Lang, Fengchao; Ribeiro, Diego Luis; Zhang, Meili; Song, Hua; Zhang, Wei; Chari, Raj; Alkaissi, Hussam; Yang, Chunzhang
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
  摘要：Mitochondria are multifunctional organelles central to both physiological and pathological processes. In malignant cancer cells, mitochondrial reprogramming establishes the metabolic foundation to meet cellular demands, which is particularly important in tumor cells with existing metabolic perturbations. To identify key mitochondrial pathways supporting cancer development, we developed mitochondria Knockout (mtKO), a robust and unbiased CRISPR screening platform to pinpoint critical mitochondr...
• The RRM domain-containing protein Rbp3 interacts with ribosomes and the 3' ends of mRNAs encoding photosynthesis proteins AI翻译
  作者：Hemm, Luisa; Lichtenberg, Elisabeth; Tholen, Stefan; Reimann, Viktoria; Kakazu, Kenta; Machida, Sotaro; Mahbub, Moontaha; Schilling, Oliver; Wilde, Annegret; Watanabe, Satoru; Mullineaux, Conrad W.; Hess, Wolfgang R.
  作者单位：University of Freiburg; University of Freiburg; University of Freiburg; Tokyo University of Agriculture; University of London; Queen Mary University London
  摘要：RNA recognition motif (RRM) domain proteins are crucial RNA- binding proteins across all domains of life. In cyanobacteria, single RRM domain proteins are involved in mRNA targeting to the thylakoid membrane and acclimation to certain stress conditions, but many details of their physiological functions and molecular targets have remained unknown. The model cyanobacterium Synechocystis sp. PCC 6803 has a family of three genes encoding the RRM domain-containing proteins Rbp1, Rbp2, and Rbp3. Her...
• Inhibiting Nav1.8 for pain: Lessons from patients and from neurons AI翻译
  作者：Waxman, Stephen G.; V. Vasylyev, Dmytro
  作者单位：Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System
• The role of estrogen receptor β in maintaining basal cells and modulating the immune environment in the prostate AI翻译
  作者：Wu, Wan-fu; Song, Xiao-yu; Warner, Margaret; Imamov, Otabeck; Antonson, Per; Gustafsson, Jan-Ake
  作者单位：University of Houston System; University of Houston; Karolinska Institutet
  摘要：Estrogen receptor R (ERR) plays an important role in both the mouse and human prostate. The endogenous ligand for ERR is the dihydrotestosterone metabolite, 5R-androstane-3R, 17R-diol (3R-Adiol). Thus, treatment with 5-alpha reductase inhibitor (5-ARI) should produce a phenotype similar to that seen in ERR-/- mice. By comparing RNA-Seq of the ventral prostates (VP) of ERR knockout mice (ERRcrispr-/-) and wild-type (WT) mice, we confirmed that ERR modulates androgen receptor (AR) signaling indi...