Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Emergence of activation or repression in transcriptional control under a fixed molecular context AI翻译
  作者：Martinez-Corral, Rosa; Friedrich, Dhana; Fromel, Robert; Velten, Lars; Gunawardena, Jeremy; DePace, Angela H.
  作者单位：Harvard University; Harvard Medical School; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; Harvard University; Howard Hughes Medical Institute; Bayer AG; Pompeu Fabra University
  摘要：Transcription factors (TFs) can be both activators and repressors of gene transcription. This can manifest as duality, where the transcriptional response increases (activation) with TF concentration in one context but decreases (repression) in another context, or as nonmonotonicity, where, in the same context, the response increases in part of the concentration range and decreases outside that range. Here we use biophysical models of gene regulation to investigate how duality and nonmonotonici...
• Disentangling metabolic and neurovascular timescales supporting cognitive processes AI翻译
  作者：Saviola, Francesca; Tambalo, Stefano; Beghini, Laura; Ferrari, Asia; Cassone, Barbara; van de Ville, Dimitri; Jovicich, Jorge
  作者单位：University of Trento; University of Brescia; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Turin; University of Turin; Norwegian University of Science & Technology (NTNU); University of Brescia; University of Milano-Bicocca; University of Geneva
  摘要：The balance between neural excitation and inhibition (EIB), governed by glutamatergic and GABAergic neurotransmission, is an essential mechanism supporting cognitive processes. Yet, little is understood about how EIB shifts with engaging cognitive load and its impact on functional connectivity dynamics. Here, we combined time-resolved functional magnetic resonance spectroscopy and magnetic resonance imaging to investigate temporal profiles of the reciprocal modulation between EIB and functiona...
• A widespread family of molecular chaperones promotes the intracellular stability of type VIIb secretion system- exported toxins AI翻译
  作者：Gkragkopoulou, Polyniki; Garrett, Stephen R.; Shah, Prakhar Y.; Grebenc, Dirk W.; Klein, Timothy A.; Kim, Youngchang; Whitney, John C.
  作者单位：McMaster University; McMaster University; United States Department of Energy (DOE); Argonne National Laboratory; McMaster University
  摘要：To survive in highly competitive environments, bacteria use specialized secretion systems to deliver antibacterial toxins into neighboring cells, thereby inhibiting their growth. In many Gram-positive bacteria, the export of such toxins requires a membrane-bound molecular apparatus known as the type VIIb secretion system (T7SSb). Recently, it was shown that toxin recruitment to the T7SSb requires a physical interaction between a toxin and two or more so-called targeting factors, which harbor k...
• Intron 1 of the C9orf72 gene: The RNA that RAN AI翻译
  作者：Hagerman, Paul J.
  作者单位：University of California System; University of California Davis
• The redox rhythm gates immune- induced cell death distinctly from the genetic clock AI翻译
  作者：Karapetyan, Sargis; Mwimba, Musoki; Chen, Tianyuan; Yao, Zhujun; Dong, Xinnian
  作者单位：Duke University; Howard Hughes Medical Institute; Duke University
  摘要：Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth's day-night cycles and regulate responses to environmental signals to gain competitive advantage. While divergent genetic clocks have been studied extensively in bacteria, fungi, plants, and animals, an ancient conserved circadian redox rhythm has been recently reported. However, its biological function and physiological outputs remain elusive. Here, we uncovered the coexistence of redox and genetic r...
• In vivo Pirt- Marina voltage sensor imaging detects primary sensory neuron-specific voltage dynamics and neuronal plasticity changes AI翻译
  作者：Zhang, Yan; Son, Hyeonwi; Shannonhouse, John; Gomez, Ruben; Kim, Eungyung; Ai, Chih - Hsuan; Chung, Man - Kyo; Platisa, Jelena; Pieribone, Vincent A.; Kim, Yu Shin
  作者单位：University System of Maryland; University of Maryland Baltimore; Yale University; The John B Pierce Laboratory, Inc; Yale University; Yale University; University of Texas System; University of Texas at San Antonio; University of Alabama System; University of Alabama Birmingham
  摘要：In vivo voltage imaging is a powerful tool for monitoring action potentials and dynamic electrical events in heterogeneous sensory neurons enabling the deciphering of rapid somatosensory information processing. Virus-driven expression of genetically encoded voltage indicator (GEVI) suffers from inconsistent expression levels and offers a limited time window for optimal voltage imaging. Here, we generated and characterized a knock-in mouse line with Pirt-driven expression of Marina, a positivel...
• Evolving choice hysteresis in reinforcement learning: Comparing the adaptive value of positivity bias and gradual perseveration AI翻译
  作者：Hoxha, Isabelle; Sperber, Leo; Palminteri, Stefano
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Institut National de la Sante et de la Recherche Medicale (Inserm)
  摘要：The tendency to repeat past choices more often than expected from the history of outcomes has been repeatedly empirically observed in reinforcement learning experiments. It can be explained by at least two computational processes: asymmetric update and (gradual) choice perseveration. A recent meta-analysis showed that both mechanisms are detectable in human reinforcement learning. However, while their descriptive value seems to be well established, they have not been compared regarding their p...
• Capturing the native structure of membrane proteins AI翻译
  作者：Liu, Hang; Tse, Chun Mong; Dang, Shangyu
  作者单位：Hong Kong University of Science & Technology; Hong Kong University of Science & Technology
  摘要：Membrane proteins play crucial roles in numerous biological processes and are important drug targets. However, structural studies of membrane proteins often rely on solubilization with detergents, which may not accurately reflect their native states in a cellular context. Additionally, identifying suitable detergents for individual membrane proteins can be a detailed and time-consuming process. Here, we developed a vesicle-based method that preserves the native lipid environment for subsequent...
• Dynamic spatial representation of self and others' actions in the macaque frontal cortex (vol 121, e2403445121, 2024) AI翻译
  作者：Ninomiya, Taihei
• A thermodynamic perspective on mammalian neural crest ingression AI翻译
  作者：Pasiliao, Clarissa C.; Thomas, Evan C.; Yung, Theodora; Zhu, Min; Tao, Hirotaka; Sun, Yu; Goyal, Sidhartha; Hopyan, Sevan
  作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto
  摘要：The ingression of neural crest cells from an ectodermal to a mesodermal layer is regulated by instructive, directional cues and potentially stochastic, biophysical parameters such as differential cell adhesion and tension heterogeneity.However, a cohesive framework in which to consider how various influences contribute to ingression remains elusive. Here, we observe the cell behaviors of the murine neural crest in three dimensions over time and apply a free energy framework to more wholly unde...