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作者：Tobias, Joseph A.; Bullock, James M.; V. Dicks, Lynn; Forester, Brenna R.; Razgour, Orly
作者单位：Imperial College London; UK Centre for Ecology & Hydrology (UKCEH); University of Cambridge; United States Department of the Interior; US Fish & Wildlife Service; University of Exeter
摘要：Conservation science and policy are geared primarily toward the preservation of species and habitats, with priority often given to the rarest, most vulnerable or most charismatic forms. This pattern-based approach has broad appeal and offers a pragmatic short-cut for targeting conservation action. However, the long-term efficacy of species and landscape conservation programs remains highly uncertain, amid growing evidence that sustainable conservation action requires an increased emphasis on p...
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作者：Jacob, Anand; Willet, Alaina H.; Igarashi, Maya G.; El Nokab, Mustapha El Hariri; Turner, Lesley A.; Alsanad, Abdulrahman Khalid A.; Wang, Tuo; Gould, Kathleen L.
作者单位：Michigan State University; Vanderbilt University
摘要：Cell walls are critical structures of fungi, bacteria, and plants, providing mechanical strength, maintaining shape, and protecting cells from environmental stress. In alpha- 1,3- glucan chains essential for cell wall integrity, but how these chains are further assembled into mature polymers is not understood. Here, we identify two conserved glycosylphosphatidylinositol- anchored alpha- amylase- like enzymes, Aah1 and Aah3, which act redundantly as key contributors to alpha- glucan network for...
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作者：Zhu, Yaguang; Xiong, Qinsi; Jeon, Woo Cheol; Blum, Monika; Camino, Fernando; Schatz, George C.; Hatzell, Kelsey B.
作者单位：Princeton University; Northwestern University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Brookhaven National Laboratory; Princeton University
摘要：Separation membranes are critical for a range of processes, including but not limited to water desalination, chemical and fuel production, and recycling and recovery applications. Fundamentally, there are intrinsic trade-offs between permeability and selectivity. Local water organization and content can impact membrane structure and impact selective ion permeation. Intercalation of chaotropic cesium (Cs+) ions within the layers reduces the water content in the membrane and at the surface which...
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作者：Huotari, Simo
作者单位：University of Helsinki
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作者：Xu, Shasha; Huang, Liangfeng; Liu, Xingjie; Zhang, Linlin; Wang, Jing; Hu, Yifeng; Yang, Yi; Shi, Xiaojie; Liu, Chaohong; Wang, Rong; Miao, Zhichao; Yu, Yong
作者单位：Tongji University; Tongji University; Tongji University; Tongji University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Youjiang Medical University for Nationalities; Guangzhou Medical University; Guangzhou Laboratory
摘要：B- 1a cells, a self- renewing B cell subset essential for innate immunity, produce natural IgM antibodies that defend against pathogens, yet mechanisms sustaining their maintenance during aging remain unclear. We report that aging B- 1a cells exhibit hallmarks of decline, including DNA damage, apoptosis, and reduced proliferation, with striking sex- specific disparities: aged females retain higher B- 1a cell numbers than males, correlating with enhanced glycolysis and chromatin accessibility. ...
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作者：Wang, Mingyi; Vladimirsky, Alexander; Giometto, Andrea
作者单位：Cornell University; Cornell University; Cornell University
摘要：Antagonistic interactions are critical determinants of microbial community stability and composition, offering host benefits such as pathogen protection and providing avenues for antimicrobial control. While the ability to eliminate competitors confers an advantage to antagonistic microbes, it often incurs a fitness cost. Consequently, many microbes only produce toxins or engage in antagonistic behavior in response to specific cues like quorum sensing molecules or environmental stress. In labo...
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作者：Burtnyak, Lyubomyr; Yuan, Yifeng; Stojek, Erwina; Pan, Xiaobei; Gunaratne, Lankani; Silveira, Gabriel; Fergus, Claire; Martinelli, Maria; Reed, Colbie J.; Fernandez, Jessie; Patel, Bhargesh Indravadan; Marquez, Isaac; Ehrenhofer-Murray, Ann E.; Swairjo, Manal A.; Alfonzo, Juan D.; Green, Brian D.; Kelly, Vincent P.; de Crecy-Lagard, Valerie
作者单位：Trinity College Dublin; State University System of Florida; University of Florida; Queens University Belfast; Brown University; Brown University; University System of Ohio; Ohio State University; Humboldt University of Berlin; California State University System; San Diego State University; State University System of Florida; University of Florida
摘要：The nucleobase queuine (q) and its nucleoside queuosine (Q) are micronutrients derived from bacteria that are acquired from the gut microbiome and/or diet in humans. Following cellular uptake, Qis incorporated at the wobble base (position 34) of tRNAs that decode histidine, tyrosine, aspartate, and asparagine codons, which is important for efficient translation. Early studies suggested that cytosolic uptake of queuine is mediated by a selective transporter that is regulated by mitogenic signal...
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作者：Hu, Yanxiao; Sheng, Ye; Huang, Jing; Xu, Xiaoxin; Yang, Yuyan; Zhang, Mingqiang; Wu, Yabei; Ye, Caichao; Yang, Jiong; Zhang, Wenqing
作者单位：Southern University of Science & Technology; Southern University of Science & Technology; Shanghai University; Southern University of Science & Technology; Southern University of Science & Technology
摘要：Using machine learning (ML) to construct interatomic interactions and thus potential energy surface (PES) has become a common strategy for materials design and simulations. However, those current models of machine-learning interatomic potential (MLIP) consider no relevant physical constraints or global scaling and thus may owe intrinsic outof-domain difficulty which underlies the challenges of model generalizability and physical scalability. Here, by incorporating the global universal scaling ...
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作者：Tabuce, Rodolphe; Marandat, Bernard; Adnet, Sylvain; Gernelle, Killian; Girard, Flavia; Marivaux, Laurent; Sole, Floreal; Schnyder, Johann; Steurbaut, Etienne; Storme, Jean-Yves; Vianey-Liaud, Monique; Yans, Johan
作者单位：Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Royal Belgian Institute of Natural Sciences; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); University of Namur
摘要：A brief global warming event known as the Pre-Onset Excursion (POE) occurred just before the Paleocene-Eocene Thermal Maximum (PETM, 56 Mya). The deconvolution of the evolutionary consequences of these two hyperthermal events is puzzling because of their close temporal proximity and the lack of comprehensive, well-calibrated paleontological records, especially in terrestrial environments. As a consequence, the impact of the POE on mammalian evolution and its role in shaping PETM faunas remains...
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作者：Li, Zhan; Kim, Hyo Jung; Luoni, Laura; Conter, Carolina; Mase, Nicola; Resentini, Francesca; Xie, Peiqiao; Astegno, Alessandra; Bonza, Maria Cristina; Hua, Jian
作者单位：Cornell University; Xianghu Laboratory; University of Milan; University of Verona
摘要：Plasma membrane-localized autoinhibited Ca2+ pumps are essential for maintaining basal cytosolic Ca2+ levels for regulating growth processes and environmental responses. These pumps are known to be activated by calmodulins to maintain Ca2+ homeostasis in plants and animals. Here, we demonstrate that the evolutionarily conserved copine protein BON1 is critical for maintaining low cytosolic Ca2+ concentrations by directly regulating two plasma membrane-localized Ca2+ pumps ACA8 and ACA10 inArabi...
