Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Multiomics analysis unveils the cellular ecosystem with clinical relevance in aldosterone- producing adenomas with KCNJ5 mutations AI翻译
  作者：Yokomoto-Umakoshi, Maki; Fujita, Masamichi; Umakoshi, Hironobu; Ogasawara, Tatsuki; Iwahashi, Norifusa; Nakatani, Kohta; Kaneko, Hiroki; Fukumoto, Tazuru; Nakao, Hiroshi; Haji, Shojiro; Kawamura, Namiko; Shimma, Shuichi; Seki, Masahide; Suzuki, Yutaka; Izumi, Yoshihiro; Oda, Yoshinao; Eto, Masatoshi; Ogawa, Seishi; Bamba, Takeshi; Ogawa, Yoshihiro
  作者单位：Kyushu University; Kyushu University; University of Osaka; University of Tokyo; Kyushu University; Kyushu University; Kyoto University
  摘要：Aldosterone- producing adenomas (APA), a major endocrine tumor and leading subtype of primary aldosteronism, cause secondary hypertension with high cardiometabolic risks. Despite potentially producing multiple steroid hormones, detailed cellular mechanisms in APA remain insufficiently studied. Our multiomics analysis focusing on APA with KCNJ5 mutations, which represent the most common genetic form, revealed marked cellular heterogeneity.Tumor cell reprogramming initiated from stress- responsi...
• TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice AI翻译
  作者：Kaneda, Yuki; Lu, Yonggang; Sun, Jiang; Shimada, Keisuke; Emori, Chihiro; Noda, Taichi; Koyano, Takayuki; Matsuyama, Makoto; Miyata, Haruhiko; Ikawa, Masahito
  作者单位：University of Osaka; University of Osaka; University of Osaka; Kumamoto University; Kumamoto University; University of Tokyo; University of Osaka; University of Osaka
  摘要：Sperm morphogenesis is a tightly regulated differentiation process, disruption of which leads to sperm malfunction and male infertility. Here, we show that Tex38 knockout (KO) male mice are infertile. Tex38 KO spermatids exhibit excess retention of residual cytoplasm around the head, resulting in abnormal sperm morphology with backward head bending. TEX38 interacts and colocalizes with ZDHHC19, a testis- enriched acyltransferase catalyzing protein S- palmitoylation, at the plasma membrane of s...
• O- GalNAc glycans are enriched in neuronal tracts and regulate nodes of Ranvier AI翻译
  作者：Noel, Maxence; Suttapitugsakul, Suttipong; Cummings, Richard D.; Mealer, Robert G.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
  摘要：Protein O-glycosylation is a critical modification in the brain, as genetic variants in the pathway are associated with common and severe neuropsychiatric phenotypes. However, little is known about the most abundant O- glycans in the mammalian brain, which are N- acetylgalactosamine (O- GalNAc) linked. Here, we determined the spatial localization, protein carriers, and cellular function of O- GalNAc glycans in the mouse brain. We observed striking spatial enrichment of O- GalNAc glycans in neu...
• ATP- sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep AI翻译
  作者：Constantino, Nicholas J.; Carroll, Caitlin M.; Williams, Holden C.; Vekaria, Hemendra J.; Yuede, Carla M.; Saito, Kai; Sheehan, Patrick W.; Snipes, J. Andy; Raichle, Marcus E.; Musiek, Erik S.; Sullivan, Patrick G.; Morganti, Josh M.; Johnson, Lance A.; Macauley, Shannon L.
  作者单位：University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
  摘要：Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required explored how changes in glucose utilization affect cortical electroencephalography (EEG) glycolysis, reducing neurotransmitter biosynthesis and dampening cortical EEG activity. ISF lactate dynamics. Together, we show that Kir6.2- KAT...
• Measuring population heterogeneity requires heterogeneous populations AI翻译
  作者：Krefeld-Schwalb, Antonia; Hua, Xuwen; Johnson, Eric J.
  作者单位：Erasmus University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam; Columbia University
• Reply to Jones et al.: Opportunities and considerations for valuing seagrass ecosystem services AI翻译
  作者：Lamb, Joleah B.; Abu, Nur; Limbong, Steven R.; Jompa, Jamaluddin; Feeney, William E.; Harvell, C. Drew
  作者单位：University of California System; University of California Irvine; Universitas Muhammadiyah Sorong; Universitas Hasanuddin; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Cornell University
• Nongenetic adaptation by collective migration AI翻译
  作者：Vo, Lam; Avgidis, Fotios; Mattingly, Henry H.; Edmonds, Karah; Burger, Isabel; Balasubramanian, Ravi; Shimizu, Thomas S.; Kazmierczak, Barbara I.; Emonet, Thierry
  作者单位：Yale University; Yale University; AMOLF; Simons Foundation; Flatiron Institute; Yale University; Yale University; Yale University
  摘要：Cell populations must adjust their phenotypic composition to adapt to changing environments. One adaptation strategy is to maintain distinct phenotypic subsets within the population and to modulate their relative abundances via gene regulation. Another strategy involves genetic mutations, which can be augmented by stress- response pathways. Here, we studied how a migrating bacterial population regulates its phenotypic distribution to traverse diverse environments. We generated isogenic Escheri...
• Automated determination of transport and depositional environments in sand and sandstones ( vol 121 , e2407655121, 2024) AI翻译
  作者：Hasson, Michael; Marvin, M. Colin; Lapotre, Mathieu G. A.
• Single- nuclei sequencing of uterine serous carcinoma reveals racial differences in immune signaling (vol 121, e2402998121, 2024) AI翻译
  作者：Foley, K. Grace; Adli, Mazhar; Kim, J. Julie
• Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway AI翻译
  作者：Takikawa, Masahiro; Nakano, Airi; Krishnaraj, Jayaraman; Tabata, Yuko; Watanabe, Yuzo; Okabe, Atsushi; Sakaguchi, Yukiko; Fujiki, Ryoji; Mochizuki, Ami; Tajima, Tomoko; Sada, Akane; Matsushita, Shu; Wakabayashi, Yuichi; Araki, Kimi; Kaneda, Atsushi; Ishikawa, Fuyuki; Sadaie, Mahito; Ohki, Rieko
  作者单位：National Cancer Center - Japan; Tokyo University of Science; Nagasaki University; Kyoto University; Chiba University; Chiba University; Chiba Cancer Center; Kumamoto University; Kumamoto University; Kyoto University
  摘要：Tumor progression is suppressed by inherent cellular mechanisms such as apoptosis. The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and plays a pivotal role in tumor suppression. RPRM is a target gene of p53 known to be involved in tumor suppression, but its molecular function has remained elusive. Here, we report that Reprimo (the protein product of RPRM) is secreted and extrinsically induces apoptosis in recipient cells. We identified FAT1, FAT4, CELSR1, CELSR2...