Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Genesis and regulation of C- terminal cyclic imides from protein damage AI翻译
  作者：Xu, Wenqing; Zhao, Zhenguang; Su, Matthew; Jain, Atul D.; Lloyd, Hannah C.; Feng, Ethan Yang; Cox, Nick; Woo, Christina M.
  作者单位：Harvard University
  摘要：C- Terminal cyclic imides are posttranslational modifications that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form of irreversible protein damage. These protein damage events are recognized and removed by the E3 ligase substrate adapter cereblon (CRBN), indicating that these aging- related modifications may require cellular quality control mechanisms to prevent deleterious effects. However, the factors that determine protein or peptide...
• Sperm meet the elevated energy demands to attain fertilization competence by increasing flux through aldolase AI翻译
  作者：Violante, Sara; Kyaw, Aye; Kouatli, Lana; Paladugu, Kaushik; Apostolakis, Lauren; Jenks, Macy; Johnson, Amy; Sheldon, Ryan D.; Whitten, Douglas; Schilmiller, Anthony L.; Visconti, Pablo E.; Cross, Justin R.; Levin, Lonny R.; Buck, Jochen; Balbach, Melanie
  作者单位：Memorial Sloan Kettering Cancer Center; Michigan State University; Van Andel Institute; Michigan State University; University of Massachusetts System; University of Massachusetts Amherst; Cornell University; Weill Cornell Medicine
  摘要：Prior to ejaculation, mammalian sperm are stored in the epididymis in a resting metabolic state. Upon ejaculation, sperm must alter their metabolism to generate the energy needed to support the motility and maturation process known as capacitation to reach and fertilize the oocyte. How sperm regulate the capacitation-induced increase in carbon flux is unknown. Here, we use 13C stable isotope labeling in mouse sperm isolated from the cauda epididymis to follow glucose metabolism through central...
• A universal wind-wave-bubble formulation for air-sea gas exchange and its impact on oxygen fluxes AI翻译
  作者：Deike, Luc; Zhou, Xiaohui; Rustogi, Paridhi; Stanley, Rachel H. R.; Reichl, Brandon G.; Bushinsky, Seth M.; Resplandy, Laure
  作者单位：Princeton University; Princeton University; Princeton University; Wellesley College; National Oceanic Atmospheric Admin (NOAA) - USA; University of Hawaii System; University of Hawaii Manoa
  摘要：Bubble-mediated gas exchange associated with wave breaking is a critical pathway for ocean-atmosphere exchange of low solubility gases such as oxygen. Yet, ocean and climate models, as well as observation-based products, usually rely on wind-only air-sea flux formulations derived from carbon constraints that ignore the asymmetric nature of the bubble flux, contributing to discrepancies between estimates of oxygen inventories and their response to climate change. Without bubbles, gas exchange i...
• The cost of banning TikTok: Implications for the digital advertising market AI翻译
  作者：Donati, Dante; Fong, Hortense
  作者单位：Columbia University
  摘要：Social media platforms have become vital channels for businesses to reach consumers through advertising. But in the United States, the digital advertising market in which these platforms operate is dominated by a few major players, raising concerns for antitrust regulators. In such a concentrated market, the entry or exit of a single platform can reallocate billions in ad spending, affecting businesses and users. TikTok's temporary suspension in the United States in January 2025 provides a uni...
• Intercellular propagation of RIPK1/RIPK3 amyloid fibrils AI翻译
  作者：Ma, Yeyang; Zhang, Qiuyuan; Li, Dekang; Zhao, Kun; Li, Zefei; Liu, Yuan; Wang, Chu; Sun, Bo; Li, Dan; Yuan, Junying; Liu, Cong
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Peking University; Chinese Academy of Sciences; Peking University; ShanghaiTech University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Fudan University
  摘要：The canonical necrosome formed by receptor-interacting protein kinase 1 (RIPK1) and RIPK3 is a functional amyloid fibril structure critical to intracellularly drive necroptosis. Since necroptosis leads to the release of intracellular content, the fate of RIPK1/RIPK3 fibrils after necroptotic cell death has not been investigated. Here, we tracked RIPK1 and RIPK3 coassemblies and found that these fibrillar aggregates could be released into the culture medium after the membrane rupture in necropt...
• Sensitization of cancer cells to DNA-damaging agents by expression of the REV1 C-terminal domain: Implications for chemotherapy AI翻译
  作者：Bian, Ke; Gruber, Charley C.; Byers, Emine; Leclerc, Paul; Hemann, Michael T.; Walker, Graham C.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：The mutagenic translesion synthesis (TLS) pathway, which is critically dependent on REV1's ability to recruit inserter TLS polymerases and the POLE extender polymerase, enables cancer cells to bypass DNA lesions while introducing mutations that likely contribute to the development of chemotherapy resistance and secondary malignancies. Targeting this pathway represents a promising therapeutic strategy. Here, we demonstrate that the expression of the C-terminal domain (CTD) of human REV1, a ca. ...
• A genetically encoded nanobody sensor reveals conformational diversity in β- arrestins orchestrated by distinct seven transmembrane receptors AI翻译
  作者：Sarma, Parishmita; Markova, Vendula Nagy; Dalal, Annu; Mishra, Sudha; Zaidi, Nashrah; Tiwari, Divyanshu; Yadav, Manish K.; Roy, Nabarun; Mahajan, Gargi; Miclea, Paul; Lazar, Josef; Shukla, Arun K.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Charles University Prague; Czech Academy of Sciences; Institute of Organic Chemistry & Biochemistry of the Czech Academy of Sciences; Charles University Prague
  摘要：Agonist-induced interaction of G protein-coupled receptors (GPCRs) with beta- arrestins (beta arrs) is a critical mechanism that regulates the spatiotemporal pattern of receptor localization and signaling. While the underlying mechanism governing GPCR-beta arr interaction is primarily conserved and involves receptor activation and phosphorylation, there are several examples of receptor-specific fine-tuning of beta arr-mediated functional outcomes. Considering the key contribution of conformati...
• Characterizing population-level changes in human behavior during the COVID-19 pandemic in the United States AI翻译
  作者：Urmi, Tamanna; Pant, Binod; Dewey, George; Quintana-Mathe, Alexi; Lang, Iris; Druckman, James; Ognyanova, Katherine; Baum, Matthew; Perlis, Roy; Riedl, Christoph; Lazer, David; Santillana, Mauricio
  作者单位：Northeastern University; Northeastern University; Harvard University; University of Rochester; Harvard University; Harvard University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Northeastern University; Northeastern University; Harvard University; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：The transmission of communicable diseases in human populations is known to be modulated by behavioral patterns. However, detailed characterizations of how population-level behaviors change over time during multiple disease outbreaks and spatial resolutions are still not widely available. We used data from 431,211 survey responses collected in the United States, between April 2020 and June 2022, to provide a description of how human behaviors fluctuated during the first 2 y of the COVID-19 pand...
• Topology and kinetic pathways of colloidosome assembly and disassembly AI翻译
  作者：Adkins, Raymond; Robaszewski, Joanna; Shin, Seungwoo; Brauns, Fridtjof; Jia, Leroy; Khanra, Ayantika; Sharma, Prerna; Pelcovits, Robert A.; Powers, Thomas R.; Dogic, Zvonimir
  作者单位：University of California System; University of California Santa Barbara; Yale University; United States Department of Defense; United States Army; U.S. Army Corps of Engineers; U.S. Army Engineer Research & Development Center (ERDC); ERDC - Risk Modeling; University of California System; University of California Santa Barbara; National Institute of Standards & Technology (NIST) - USA; Indian Institute of Science (IISC) - Bangalore; Indian Institute of Science (IISC) - Bangalore; Brown University; Brown University
  摘要：Closed capsules, such as lipid vesicles, soap bubbles, and emulsion droplets, are ubiquitous throughout biology, engineered matter, and everyday life. Their creation and disintegration are defined by a singularity that separates a topologically distinct extended liquid film from a boundary-free closed shell. Such topology-changing processes are of fundamental interest. They are also essential for intercellular transport, transcellular communication, and drug delivery. However, studies of vesic...
• Long- term history of continental weathering and particle transport to the sea AI翻译
  作者：Canfield, Don E.; Zhang, Shuichang; Mitchell, Ross N.; Wang, Xiaomei; Naemi, Amin; Spencer, Christopher J.; Zhang, Pengyaun
  作者单位：University of Southern Denmark; China National Petroleum Corporation; Chinese Academy of Sciences; Institute of Geology & Geophysics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Queens University - Canada
  摘要：Here, we explore the long-term history of chemical weathering and particle transport from the continents to the oceans by leveraging the histories of Zr/Al, Rb/Al, and Na/Al in marine sediments over the last 2000 My. We interpret these data in the context of elemental behavior in modern weathering environments and modern marine sediments. We find that from 2000 Mya to ca. 650 Mya, physical erosion was effective, where braided rivers efficiently delivered particles from land to the sea. Overall...