ATP- sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

• 成果类型: Article
• 署名作者: Constantino, Nicholas J.; Carroll, Caitlin M.; Williams, Holden C.; Vekaria, Hemendra J.; Yuede, Carla M.; Saito, Kai; Sheehan, Patrick W.; Snipes, J. Andy; Raichle, Marcus E.; Musiek, Erik S.; Sullivan, Patrick G.; Morganti, Josh M.; Johnson, Lance A.; Macauley, Shannon L.
• 署名单位: University of Kentucky; University of Kentucky; University of Kentucky; University of Kentucky; Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11071
• DOI: 10.1073/pnas.2416578122
• 发表日期: 2025-02-25
• 关键词: brain energetics; oscillations; lactate; alpha; eeg; astrocytes; release; neurons; cns

摘要

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where increased interstitial fluid (ISF) lactate levels are associated with wakefulness and decreased ISF lactate is required explored how changes in glucose utilization affect cortical electroencephalography (EEG) glycolysis, reducing neurotransmitter biosynthesis and dampening cortical EEG activity. ISF lactate dynamics. Together, we show that Kir6.2- KATP channels act as metabolic sensors to gate arousal by maintaining the metabolic stability of sleep/wake states and providing the metabolic flexibility to transition between states.