Proceedings of the National Academy of Sciences of the United States of America

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• Client-scaffold interactions suppress aggregation of a client protein in model condensates AI翻译
  作者：Ahmed, Rashik; Hudson, Rhea P.; Forman-Kay, Julie D.; Kay, Lewis E.
  作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; Hospital for Sick Children (SickKids)
  摘要：Many studies have shown that sequestration of client proteins into condensates locally increases their concentrations and/or modulates their conformational landscapes to promote aberrant aggregation. Far fewer examples have emerged where the proteinaceous condensed phase environment protects clients from aggregation. Here, we show that a condensate scaffolded by the C-terminal disordered region of Cell Cycle Associated Protein 1 (CAPRIN1) suppresses aggregation of the Fused in Sarcoma (FUS) RN...
• Ensemble approaches for short-term dengue fever forecasts: A global evaluation study AI翻译
  作者：Io, Skyler Wu; Meyer, Austin G.; Clemente, Leonardo; Stolerman, Lucas M.; Lu, Fred; Majumder, Atreyee; Verbeeck, Rudi; Masyn, Serge; Santillana, Mauricio
  作者单位：Harvard University; Northeastern University; Baylor College of Medicine; Oklahoma State University System; Oklahoma State University - Stillwater; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Dengue fever, a tropical vector-borne disease, is a leading cause of hospitalization and death in many parts of the world, especially in Asia and Latin America. Where timely dengue surveillance exists, decision-makers can better implement public health measures and allocate resources. Reliable near-term forecasts may help anticipate healthcare demands and promote preparedness. We propose ensemble modeling approaches combining mechanistic, statistical, and machine learning models to forecast de...
• Phase transfer-driven formation of solid metal-organic materials with tunable optical and adsorption properties AI翻译
  作者：Du, Jia- Xing; Liu, Lingran; Yu, Mei- Lin; Zhang, Fengmin; Stang, Peter J.; Sun, Yan
  作者单位：Henan University; Yangzhou University; Utah System of Higher Education; University of Utah
  摘要：Precise control of the physicochemical properties of metal-organic materials has been a challenge in the fields of materials science and engineering and can be achieved through the construction of morphology/size-dependent supramolecular functional model systems. The development of diverse hierarchical micro/nanostructured systems based on similar molecules and the elucidation of their morphology-dependent characteristics provide the possibility for efficiently constructing this system and stu...
• Schaumann and Alastrué de Asenjo, Weakening AMOC reduces ocean carbon uptake and increases the social cost of carbon ( vol 122 , e2419543122 , 2025 ) AI翻译
  作者：Schaumann, Felix; de Asenjo, Eduardo Alastrue
• Brian Larkins, a plant science pioneer, leader, mentor, and friend AI翻译
  作者：Boston, Rebecca S.; Marks, M. David; Cohen, Jerry D.
  作者单位：North Carolina State University; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Brian Larkins died in January 2025 at the age of 78 leaving a legacy of seminal scientific contributions that were fundamental to the establishment of the field of plant molecular biology. He elucidated the key processes in maize endosperm development and delivered technical breakthroughs in isolation of polysomes and translation of associated messenger RNAs. His models for protein body structure and his work to understand the molecular basis for restoring transparency to mutant maize seeds pr...
• Early-life human CD8+T cells exhibit rapid, short-lived effector responses and a unique transcription factor landscape AI翻译
  作者：Brodsky, Nina N.; Chakder, Monisha; Kumar, Dinesh Babu Uthaya; Barmada, Anis; Wang, Julia; Gu, Weihong; Olaloye, Oluwabunmi; Ramaswamy, Anjali; Wats, Aanchal; Konnikova, Liza; Lucas, Carrie L.
  作者单位：Yale University; Yale University; Yale University; Yale University
  摘要：Neonates and infants are distinct in their clinical and cellular responses to viral infections, with neonatal CD8+ T cells displaying innate-like characteristics and a low threshold for T cell receptor activation. However, specific molecular programs that drive these unique responses are incompletely understood, particularly in humans, and targetable pathways to modulate viral illness in this vulnerable population remain to be elucidated. Early-life immune responses may be developmentally prog...
• Ancient seabed checkerboard: How setae shaped spatial distributions of Silurian brachiopods AI翻译
  作者：Huang, Bing; Rong, Jiayu
  作者单位：Chinese Academy of Sciences
  摘要：Understanding the drivers of spatial patterns in fossil communities is fundamental to paleoecology, yet direct evidence for biological mechanisms regulating interindividual spacing remains elusive. Brachiopod setae, hypothesized to function in feeding or defense, are exceedingly rare in the fossil record, especially among post-Cambrian taxa. Here, we present the report of exquisitely preserved setae from an exceptional in situ fossil assemblage of the early Silurian rhynchonelliform brachiopod...
• Epigenetic instability and hypofunctionality of fetal Tregs allow a permissive regulatory environment for T effector memory maturation AI翻译
  作者：Leong, Jing Yao; McGovern, Naomi; Mishra, Archita; Wasser, Martin; Kumar, Pavanish; Tay, Shi Huan; Hazirah, Sharifah Nur; Yeo, Joo Guan; Tan, Xiu Qi; Sutamam, Nursyuhadah; Azman, Farah Nadiah; Chua, Camillus Jian Hui; Chen, Phyllis ZiXuan; Ally, Fauziah; Dutertre, Charles- Antoine; Ramakrishna, Lakshmi; Poh, Su Li; Xie, Lian; Fan, Yiping; Donner, Catherine; Papadopoulou, Maria; Vermijlen, David; Arkachaisri, Thaschawee; Chan, Jerry Kok Yen; Ginhoux, Florent; Albani, Salvatore
  作者单位：University of Cambridge; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); University of Sydney; KK Women's & Children's Hospital; UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay; National University of Singapore; KK Women's & Children's Hospital; National University of Singapore; Universite Libre de Bruxelles; Universite Libre de Bruxelles; Universite Libre de Bruxelles
  摘要：The human gestational environment is commonly perceived to be predominantly suppressive and incompatible for T effector maturation. However, evidence of a competent effector fetal environment is mounting in the field. Here, we employed a high parametric, mass cytometry-based approach to study the fetal circulatory and microenvironmental immunomes, with the aim to understand the inception and extent of fetal effector T cell priming and its relation with regulatory mechanisms. We found evidence ...
• A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition AI翻译
  作者：Myers, Luke S.; Christian, Sarah G.; Simpson, Sean; Sper, Renan; Taylor, Clint; Montes, Laura; Jepp, Thomas B. C.; Ramos, Daniela; Schuller, Livia; Konganti, Kranti; Friedeck, Wade; Habib, Ozair; Hodge, McKaela; Taylor, Alasdair J.; Coffell, Ashley; Schlafer, Annalise; Matt, Morgan; Revell, Bradley; Knight, Carol; Barrena, Cristina C.; Murphy, William J.; Weeber, Edwin J.; Segal, David J.; Anderson, Anne; Nash, Kevin R.; Silvermanj, Jill L.; Piedrahita, Jorge A.; Dindot, Scott V.
  作者单位：Texas A&M University System; Texas A&M University College Station; University of Surrey; North Carolina State University; North Carolina State University; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station; State University System of Florida; University of South Florida; University of California System; University of California Davis; University of California System; University of California Davis; Baylor College of Medicine; Baylor College of Medicine; University of California System; University of California Davis; Ultragenyx Pharmaceutical Inc.
  摘要：Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A (UBE3A) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show that pigs (Sus scrofa) with a maternally inherited deletion of UBE3A (UBE3A-/+) hav...
• Phage-based delivery of CRISPR-associated transposases for targeted bacterial editing AI翻译
  作者：Roberts, Avery; Adler, Benjamin A.; Cress, Brady F.; Doudna, Jennifer A.; Barrangou, Rodolphe
  作者单位：North Carolina State University; University of California System; University of California Berkeley
  摘要：Phage lambda, a well- characterized temperate phage, has been recently leveraged for bacterial genome editing by selectively delivering base editors into targeted bacterial species. We extend this concept by engineering phage lambda to deliver CRISPR- guided transposases, accomplishing large insertions and targeted gene disruptions. To achieve this, we engineered phage lambda using homologous recombination paired with Cas13a- based counterselection for precise phage modifications. Initially, w...