Proceedings of the National Academy of Sciences of the United States of America

最新文章

• Hdac1 as an early determinant of intermediate- exhausted CD8+T cell fate in chronic viral infection AI翻译
  作者：Hu, Wei; Hu, Shengen Shawn; Zhu, Shaoqi; Peng, Weiqun; Badovinac, Vladimir P.; Zang, Chongzhi; Zhao, Xudong; Xue, Hai-Hui
  作者单位：Hackensack University Medical Center; University of Virginia; University of Virginia; George Washington University; Sun Yat Sen University; University of Iowa; China Medical University
  摘要：The exhausted CD8+ T (TEX) cells consist of distinct subsets including Tcf1+ stem-like, Tcf1-Cx3cr1+ intermediate (TEX-int) and Tcf1-Cx3cr1-terminally exhausted cells; yet, epigenetic determinants of TEX subset differentiation remain incompletely understood. Using chronic viral infection, we show that histone deacetylase 1 (Hdac1) was specifically required for the formation of antigen-specific TEX-int cells at the effector phase of responses. Single-cell transcriptomics validated that Hdac1 de...
• 撤稿声明: Role of test motivation in intelligence testing AI翻译
  作者：Duckworth, Angela Lee; Quinn, Patrick D.; Lynam, Donald R.
• Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells AI翻译
  作者：Ferrero, Giulio; Cardamone, Maria Dafne; Luca, Francesca; Bourk, Eliot; Ricci, Laura; Liu, Wen; Gao, Yuan; Burrone, Giulia; Muhammad, Akhirah; Chan, Stefanie; Smith, Emma; Fan, Ting-Yu Claire; Cutrupi, Santina; Garcia -Bassets, Ivan; De Bortoli, Michele; Rosenfeld, Michael G.; Perissi, Valentina
  作者单位：University of Turin; Boston University; University of California System; University of California San Diego; University of Turin
  摘要：Tight regulation of gene expression is achieved through the coordinated action of transcription factors and cofactors that often can act as both repressors and activators in response to regulatory signals, with their activity modulated by context-specific signal transduction pathways that also impinge on their transient and cyclical recruitment to chromatin. However, the mechanisms underlying the intricate interplay between the regulatory strategies controlling cofactors' activity and localiza...
• Combining live fluorescence imaging with in situ cryoelectron tomography sheds light on the septation process in Deinococcus radiodurans AI翻译
  作者：Gaifas, Lorenzo; Kleman, Jean - Philippe; Lacroix, Francoise; Schexnaydre, Erin; Trouve, Jennyfer; Morlot, Cecile; Sandblad, Linda; Gutsche, Irina; Timmins, Joanna
  作者单位：Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CEA; Centre National de la Recherche Scientifique (CNRS); Umea University; Umea University
  摘要：Cell division is a fundamental biological process that allows a single mother cell to produce two daughter cells. In walled bacteria, different modes of cell division have been reported that are notably associated with distinctive cell shapes. In all cases, division involves a step of septation, corresponding to the growth of a new dividing cell wall, followed by splitting of the two daughter cells. The radiation-resistant Deinococcus radiodurans is a spherical bacterium protected by a thick a...
• Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4 AI翻译
  作者：Kostritskii, Andrei Y.; Kostritskaia, Yulia; Dmitrieva, Natalia; Stauber, Tobias; Machtens, Jan-Philipp
  作者单位：Helmholtz Association; Research Center Julich; MSH Medical School Hamburg; Hannover Medical School
  摘要：TMEM16A is a Ca2+-activated Cl-channel that has crucial roles in various physiological and pathological processes. However, the structure of the open state of the channel and the mechanism of Ca2+-induced pore opening have remained elusive. Using extensive molecular dynamics simulations, protein structure prediction, and patch-clamp electrophysiology, we demonstrate that TMEM16A opens a hydrated Cl--conductive pore via a pi-helical transition in transmembrane segment 4 (TM4). We also describe ...
• Molecular organization of central cholinergic synapses AI翻译
  作者：Rosenthal, Justin S.; Zhang, Dean; Yin, Jun; Long, Caixia; Yang, George; Li, Yan; Lu, Zhiyuan; Li, Wei-Ping; Yu, Zhiheng; Li, Jiefu; Yuan, Quan
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Howard Hughes Medical Institute
  摘要：Synapses have undergone significant diversification and adaptation, contributing to the complexity of the central nervous system. Understanding their molecular architecture is essential for deciphering the brain's functional evolution. While nicotinic acetylcholine receptors (nAchRs) are widely distributed across metazoan brains, their associated protein networks remain poorly characterized. Using in vivo proximity labeling, we generated proteomic maps of subunit- specific nAchR interactomes i...
• Start your engines: How migratory fibroblasts respond to and remember mechanical stretch AI翻译
  作者：Weihs, Daphne
  作者单位：Technion Israel Institute of Technology; Ghent University; Ghent University Hospital; Hasselt University; Hasselt University
• The tilt illusion arises from an efficient reallocation of neural coding resources at the contextual boundary AI翻译
  作者：Zhang, Ling-Qi; Mao, Jiang; Aguirre, Geoffrey K.; Stocker, Alan A.
  作者单位：University of Pennsylvania; University of Pennsylvania
  摘要：The tilt illusion-a bias in the perceived orientation of a center stimulus induced by an oriented surround-illustrates how context shapes visual perception. Although extensively studied for decades, we still lack a comprehensive account of the illusion that connects its behavioral and neural characteristics. Here, we demonstrate that the tilt illusion originates from dynamic changes in neural coding precision induced by the surround context. We simultaneously obtained psychophysical and functi...
• tRNA selectivity during ribosome-associated quality control regulates the critical sterility-inducing temperature in two-line hybrid rice (vol 122, e2417526122, 2025) AI翻译
  作者：Zhou, Can; Liu, Chunyan; Yan, Bin; Sun, Jing; Li, Shengdong; Li, Ji; Wang, Jia; Huang, Xiahe; Yan, Wei; Yang, Shuying; Fu, Chenjian; Qin, Peng; Fu, Xingxue; Zhao, Xinghui; Wu, Yaxian; Song, Xianwei; Wang, Yingchun; Qian, Wenfeng; Yang, Yuanzhu; Cao, Xiaofeng
• A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression AI翻译
  作者：Bashyal, Sagar; Everett, Hasani; Matsuura, Suzanne; Muller, Lena Maria
  作者单位：Salk Institute; University of California System; University of California San Diego; University of Miami
  摘要：CLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides have emerged as key regulators of plant-microbe interactions, including arbuscular mycorrhizal (AM) symbiosis. Here, we identify Medicago truncatula CLE16 as a positive regulator of AM symbiosis. MtCLE16is expressed in root cells colonized by AM fungi (AMF) and its overexpression within colonized tissues increases arbuscule abundance by finetuning their growth and lifespan. Functional and transcriptomic analyses reveal that MtCLE16 acts...