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作者：Huang, Qiuyu J.; Kim, Ryan; Song, Kangkang; Grigorieff, Nikolaus; Munro, James B.; Schiffer, Celia A.; Somasundaran, Mohan
作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
摘要：Influenza viruses are enveloped, negative-sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80 to 90% of influenza glycoprotein and plays a role in host cell binding and membrane fusion. While previous studies have characterized structures of purified receptor-free and receptor-bound HA, the effect of receptor binding on HA organization and structure on virions remains unknown. Here, we used cryoelectron tomography to visualize influen...
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作者：Kalenscher, Tobias; Luepken, Luca M.; Stoop, Ron; Terburg, David; van Honk, Jack
作者单位：Heinrich Heine University Dusseldorf; Utrecht University; University of Cape Town
摘要：Translational research suggests that the basolateral part of the amygdala (BLA) computes some of the core processes underlying social preferences, but its precise role in prosocial choice remains unclear. We hypothesize that the human BLA is not necessary for prosocial behavior per se, but fine-tunes the degree of prosociality as a function of the social distance between actor and recipient of a prosocial act. We tested five participants with Urbach-Wiethe disease (UWD) who had isolated, bilat...
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作者：Ke, Bingyuan; Wang, Xinghui
作者单位：Fuzhou University; Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China
摘要：Large- scale integration of microbattery systems on chips has long been hindered by the technical barrier between electrochemistry and microelectronics, particularly in terms of the compatibility of microbattery cells and their collective manufacturability. In this work, a silicon- based all- solid- state thin- film microbattery cell is developed at low temperatures for on- chip integration applications. Stress management at the interfaces covering both the resistance to interfacial fracture a...
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作者：Singh, Gaurav; Vengayil, Vineeth; Khanna, Aayushee; Adhikary, Swagata; Laxman, Sunil
作者单位：Department of Biotechnology (DBT) India; Institute for Stem Cell Biology & Regenerative Medicine - inStem; University of Pennsylvania
摘要：Mitochondria are dynamic organelles that constantly change morphology. What controls mitochondrial morphology however remains unresolved. Using actively respiring yeast cells growing in distinct carbon sources, we find that mitochondrial morphology and activity are unrelated. Cells can exhibit fragmented or networked mitochondrial morphology in different nutrient environments independent of mitochondrial activity. Instead, mitochondrial morphology is controlled by the intracellular redox state...
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作者：Wang, Qian; Kang, Yeon Hee; Hardtke, Christian S.
作者单位：University of Lausanne
摘要：Cellular signaling processes can elicit powerful responses and may need to be amplified to be efficient or dampened to prevent overstimulation. Therefore, they often involve autoregulatory feedbacks. Receptor kinase signaling pathways are abundant in plants, where they convey the presence of both exogenous and endogenous ligands. Among them, endogenous CLAVATA3/EMBRYO SURROUNDING REGION (CLE) peptide signaling acts in an inherently quantitative manner to determine the size of stem cell pools a...
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作者：He, Ling; Azizad, Daria; Bhat, Kruttika; Ioannidis, Angeliki; Hoffmann, Carter J.; Arambula, Evelyn; Eghbali, Mansoureh; Bhaduri, Aparna; Kornblum, Harley I.; Pajonk, Frank
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作者：Itao, Kenji; Kaneko, Kunihiko
作者单位：RIKEN; University of Copenhagen; Niels Bohr Institute
摘要：Social institutions are systems of shared norms and rules that regulate people's behaviors, often emerging without external enforcement. They provide criteria to distinguish cooperation from defection and establish rules to sustain cooperation, shaped through long-term trial and error. While principles for successful institutions have been proposed, the mechanisms underlying their emergence remain poorly understood. To address this, we introduce the evolutionary dynamical-systems game theory t...
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作者：Bombari, Simone; Mondelli, Marco
作者单位：Institute of Science & Technology - Austria
摘要：Differentially private gradient descent (DP-GD) is a popular algorithm to train deep learning models with provable guarantees on the privacy of the training data. In the last decade, the problem of understanding its performance cost with respect to standard GD has received remarkable attention from the research community, which has led to upper bounds on the excess population risk RP in different learning settings. However, such bounds typically degrade with overparameterization, i.e., as the ...
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作者：Fay, Philip A.; Gherardi, Laureano A.; Yahdjian, Laura; Adler, Peter B.; Bakker, Jonathan D.; Bharath, Siddharth; Borer, Elizabeth T.; Harpole, W. Stanley; Green, Erika Hersch -; Huxman, Travis E.; Macdougall, Andrew S.; Risch, Anita C.; Seabloom, Eric W.; Bagchi, Sumanta; Barrio, Isabel C.; Biederman, Lori; Buckley, Yvonne M.; Bugalho, Miguel N.; Caldeira, Maria C.; Catford, Jane A.; Chen, Qingqing; Cleland, Elsa E.; Collins, Scott L.; Daleo, Pedro; Dickman, Christopher R.; Donohue, Ian; Dupre, Mary E.; Eisenhauer, Nico; Eskelinen, Anu; Hagenah, Nicole; Hautier, Yann; Heckman, Robert W.; Jonsdottir, Ingibjoerg S.; Knops, Johannes M. H.; Laungani, Ramesh; Martina, Jason P.; Mcculley, Rebecca L.; Morgan, John W.; Venterink, Harry Olde; Peri, Pablo L.; Power, Sally A.; Raynaud, Xavier; Ren, Zhengwei; Roscher, Christiane; Smith, Melinda D.; Spohn, Marie; Stevens, Carly J.; Tedder, Michelle J.; Virtanen, Risto; Wardle, Glenda M.; Wheeler, George R.
作者单位：United States Department of Agriculture (USDA); University of California System; University of California Berkeley; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; Utah System of Higher Education; Utah State University; Utah System of Higher Education; Utah State University; University of Minnesota System; University of Minnesota Twin Cities; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Helmholtz Association; Helmholtz Center for Environmental Research (UFZ); Martin Luther University Halle Wittenberg; Michigan Technological University; University of Guelph; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Indian Institute of Science (IISC) - Bangalore; Iowa State University; Trinity College Dublin; Universidade de Lisboa; Universidade de Lisboa; Centro de Estudos Florestais; University of London; King's College London; Australian National University; Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN); University of California System; University of California San Diego; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Mar del Plata; University of Sydney; Trinity College Dublin; Leipzig University; University of Oulu; University of Pretoria; Utrecht University; University of North Carolina; University of North Carolina Chapel Hill; University of Texas System; University of Texas Austin; University of Iceland; Xi'an Jiaotong-Liverpool University; Marist College; Texas State University System; Texas State University San Marcos; University of Kentucky; La Trobe University; Vrije Universiteit Brussel; Western Sydney University; Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Institut National de la Sante et de la Recherche Medicale (Inserm); Lanzhou University; Lanzhou University; Colorado State University System; Colorado State University Fort Collins; Swedish University of Agricultural Sciences; Lancaster University; University of Kwazulu Natal; University of Sydney; University of Nebraska System; University of Nebraska Lincoln
摘要：Ecosystems are experiencing changing global patterns of mean annual precipitation (MAP) and enrichment with multiple nutrients that potentially colimit plant biomass production. In grasslands, mean aboveground plant biomass is closely related to MAP, but how this relationship changes after enrichment with multiple nutrients remains unclear. We hypothesized the global biomass-MAP relationship becomes steeper with an increasing number of added nutrients, with increases in steepness corresponding...
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作者：Chakraborty, Saikat; Martinez-Sanchez, Antonio; Beck, Florian; Toro-Nahuelpan, Mauricio; Hwang, In-Young; Noh, Kyung-Min; Baumeister, Wolfgang; Mahamid, Julia
