Proceedings of the National Academy of Sciences of the United States of America

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• Reply to Falkingham et al.: Trackway shows flap- running in feathered dinosaurs AI翻译
  作者：Dececchi, T. Alexander; Kim, Kyung Soo; Lockley, Martin G.; Larsson, Hans C. E.; Holtz Jr, Thomas H.; Farlow, James O.; Pittman, Michael
  作者单位：Dakota State University; University of Colorado System; University of Colorado Denver; McGill University; University System of Maryland; University of Maryland College Park; Smithsonian Institution; Smithsonian National Museum of Natural History; Purdue University System; Indiana University Purdue University Fort Wayne; Chinese University of Hong Kong
• Reactivation of memory- associated neurons induces downstream suppression of competing neuronal populations AI翻译
  作者：Norman, Jacob F.; Rahsepar, Bahar; Vena, Anna; Thunemann, Martin; Devor, Anna; Ramirez, Steve; White, John A.
  作者单位：Boston University; Boston University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Boston University
  摘要：Inducing apparent memory recall by tagging and optogenetically reactivating cells in the hippocampus was demonstrated over a decade ago. However, the hippocampal dynamics resulting from this reactivation remain largely unknown. While calcium imaging is commonly used as a measure of neuronal activity, GCaMP, the most common calcium indicator, cannot be used with optogenetic neuronal reactivation because both require blue light excitation. To resolve this overlap, we demonstrate optogenetic reac...
• Unveiling Cas8 dynamics and regulation within a transposon- encoded Cascade-TniQ complex AI翻译
  作者：Patel, Amun C.; Sinha, Souvik; Arantes, Pablo R.; Palermo, Giulia
  作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
  摘要：The Vibrio cholerae Cascade-TniQ complex unveiled a new paradigm in biology, demonstrating that CRISPR-associated proteins can direct DNA transposition. Despite the tremendous potential of knocking-in genes at desired sites, the mechanisms underlying DNA binding and transposition remain elusive. In this system, a conformational change of the Cas8 protein is essential for DNA binding, yet how it occurs is unclear. Here, structural modeling and free energy simulations reconstruct the Cas8 helica...
• HIPK2 phosphorylates HDAC3 for NF-κB acetylation to ameliorate colitis-associated colorectal carcinoma and sepsis (vol 118, e2021798118, 2021) AI翻译
  作者：Zhang, Fang; Qi, Linlin; Feng, Qiuyun; Zhang, Baokai; Li, Xiangyue; Liu, Chang; Li, Weiyun; Liu, Qiaojie; Yang, Dan; Yin, Yue; Peng, Chao; Wu, Han; Tang, Zhao-Hui; Zhou, Xi; Xiang, Zou; Zhang, Zhijiang; Wang, Hongyan; Wei, Bin
• Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo AI翻译
  作者：Din, Hengwei; Liu, Zixin; Mou, Dialing; Tang, Muxue; Huang, Xiuzhen; Liu, Kuo; Zhang, Qianyu; Lui, Kathy O.; Zhou, Bin
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital
  摘要：In recent decades, the traditional paradigm of three distinct germ layers formed during gastrulation has been revised with the identification of neuromesodermal progenitors (NMPs). These progenitors emerge during gastrulation and contribute to both the neural ectoderm, particularly the spinal cord, and the adjacent paraxial mesoderm [D. Henrique et al., Development 142, 2864-2875 (2015); R. J. Garriock et al., Development 142, 1628-1638 (2015); E. Tzouanacou et al., Dev. Cell 17, 365-376 (2009...
• Allosteric mechanism in the distinctive coupling of Gq and Gs to the parathyroid hormone type 1 receptor AI翻译
  作者：Zhang, Xuan; Lee, Ji Young; Pacheco, Jonathan; Sutkeviciute, Ieva; Anitha, Anju Krishnan; Liu, Heng; Singh, Stephanie; Ventura, Carlos; Savransky, Sofya; Khatri, Ashok; Zhang, Cheng; Bahar, Ivet; Vilardaga, Jean-Pierre
  作者单位：Guangzhou Medical University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; State University of New York (SUNY) System; Stony Brook University; State University of New York (SUNY) System; Stony Brook University; Stony Brook University Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; US Department of Veterans Affairs
  摘要：The mechanism determining the preferential stimulation of one heterotrimeric G protein signaling pathway over another by a ligand remains undetermined. By reporting the cryogenic electron microscopy (cryo-EM) structure of the parathyroid hormone (PTH) type 1 receptor (PTH1R) complexed with Gq and comparing its allosteric dynamics with that of PTH1R in complex with Gs, we uncover a mechanism underlying such preferences. We show that an allosteric coupling between the ligand PTH and the C-termin...
• Predicting nature- based coastal protection by mangroves under extreme waves AI翻译
  作者：Hu, Zhan; Temmerman, Stijn; Zhu, Qin; Wang, Xinran; Wu, Jinwei; Xu, Tianping; Schoutens, Ken; Suzuki, Tomohiro; Yang, Zhifeng; Bouma, Tjeerd J.
  作者单位：Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sun Yat Sen University; Sun Yat Sen University; Guangdong Provincial Key Laboratory of Marine Resources & Coastal Engineering; University of Antwerp; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou); KU Leuven; Guangdong University of Technology; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Utrecht University
  摘要：Forested wetlands such as mangroves are considered highly valuable for nature- based mitigation of coastal flooding. However, their wave attenuation capacity during extreme storms, when risks are highest, is rarely measured and remains challenging to predict. Here, we compile a unique dataset on the largest incident wave heights (0.39 to 1.44 m) ever recorded in forested wetlands, including our own measurements and literature data. Our analysis reveals that forested wetlands can significantly ...
• Efficient mapping of the thalamocortical monosynaptic connectivity in vivo by tangential insertions of high-density electrodes in the cortex (vol 121, e2313048121, 2024) AI翻译
  作者：[Anonymous]
• Infant EEG microstate dynamics relate to fine- grained patterns of infant attention during naturalistic play with caregivers AI翻译
  作者：Bagdasarov, Armen; Markert, Sarah; Gaffrey, Michael S.
  作者单位：Duke University; Children's Hospital of Wisconsin; Medical College of Wisconsin
  摘要：As infants grow, they develop greater attentional control during interactions with others, shifting from patterns of attention primarily driven by caregivers (exogenous) to those that are also self- directed (endogenous). The ability to endogenously control attention during infancy is thought to reflect ongoing brain development and is influenced by patterns of joint attention between infant and caregiver. However, whether measures of infant attentional control and caregiver behavior during in...
• Resilient tree- planting strategies for carbon dioxide removal under compounding climate and economic uncertainties AI翻译
  作者：Cho, Frankie H. T.; Aglonucci, Paolo; Bateman, Ian J.; Lee, Christopher F.; Lovett, Andrew; Mancini, Mattia C.; Rapti, Chrysanthi; Day, Brett H.
  作者单位：University of Exeter; University of Queensland; University of Queensland; University of London; University College London; University of East Anglia
  摘要：To meet decarbonization targets, nations around the globe have made ambitious commitments to expand forested land. Operationalizing these commitments requires choosing a planting strategy: How many trees should be planted, of which species, and where? Given those choices must be made now but have long- term consequences, such decisions are plagued by uncertainty. For example, species that are well suited to present conditions may perform poorly under future climates, yet those future climates ...