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作者:Wilke, Claus O.; Vieira, Luiz C.
作者单位:University of Texas System; University of Texas Austin
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作者:Yang, Bao; Wang, Xuelian
作者单位:Nanjing University; Chinese Academy of Sciences
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作者:Dubilier, Nicole
作者单位:Max Planck Society
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作者:Takeuchi, Marie; Matsunaga, Mami; Kita, Tomoko; Nishimura, Koji; Tona, Yosuke; Omori, Koichi; Katsuno, Tatsuya; Nakagawa, Takayuki
作者单位:Kyoto University; Kyoto University
摘要:The mammalian cochlea loses its ability to regenerate hair cells (HCs) after birth. In contrast, in the avian auditory epithelium, the basilar papilla (BP), supporting cells (SCs) retain the capability for HC regeneration throughout life. Our previous study using single-cell RNA sequencing indicated a stepwise fate conversion of SCs to HCs via a precursor state, in which endothelin receptor type B2 (EDNRB2) exhibited specifically high expression during HC regeneration in chick BP. This study a...
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作者:Fang, Yanan; Olsen, Paul E.; Sha, Jingeng; Whiteside, Jessica H.; Guan, Chengguo; Ikeda, Masayuki; Li, Sha; Zheng, Daran; Zhang, Haichun; Wang, Bo
作者单位:Chinese Academy of Sciences; Columbia University; Columbia University; California State University System; San Diego State University; University of Tokyo
摘要:Solar system gravitational interactions are embedded in Earth's record of climate, providing a way to bypass the 60 Myr limit imposed by chaos. Presently with a 2.4 Myr period, the Mars-Earth beat cycle of orbital perihelion frequencies is particularly sensitive to chaotic diffusion, potentially varying by more than a million years. Early Mesozoic (252 to 145 Ma) strata provide some constraints on this cycle, with evidence of a swing through most of the solution space from 1.8 Myr at 210 Ma to...
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作者:Hoshikawa, Yojiro; Shirota, Natsuho; Tsugawa, Hiroshi; Kimura, Satoshi; Matsuyama, Akihisa; Yashiroda, Yoko; Kakeya, Hideaki; Arita, Makoto; Iizumi, Reiko; Yoshida, Minoru; Nishimura, Shinichi
作者单位:University of Tokyo; Hiroshima University; Hiroshima University; RIKEN; RIKEN; Yokohama City University; Tokyo University of Agriculture & Technology; University of Tokyo; RIKEN; Kyoto University; Keio University; Keio University; University of California System; University of California San Diego; Scripps Institution of Oceanography; University of Tokyo; University of Tokyo; RIKEN
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作者:Miao, Runze; Howard, Alan D.; Dietrich, William E.
作者单位:University of California System; University of California Berkeley; University of Virginia
摘要:The discovery of paleo-meanders on Mars and debates about the occurrence of meandering on prevegetation early Earth have stimulated field studies of channel morphology and deposit stratigraphy in arid environments. They show that mud can provide the cohesive strength to retard outer bank erosion, enabling inner bank lateral accretion (including mud deposition) to keep pace and thus sustain meandering. The process by which mud is deposited in the lateral accretion deposits, however, is poorly k...
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作者:Ruby, Carolyn; Novick, Richard P.
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作者:Kao, Kevin S.; Pihlstrom, Nicole L.; Niejadlik, Emily G.; Cantaert, Tineke; Ahmed, Rafi; Ravetch, Jeffrey, V; Bournazos, Stylianos
作者单位:Rockefeller University; Pasteur Network; Institut Pasteur Cambodia; Emory University; Emory University; Emory University
摘要:A critical component of the function of IgG antibodies is their capacity to engage specialized cellular receptors, Fc gamma receptors (Fc gamma Rs), expressed on effector leukocytes. Highlighting the importance of Fc gamma R-mediated signaling in the regulation of the fate, activation, and differentiation status of leukocytes, Fc gamma Rs are ubiquitously expressed by nearly all leukocyte populations. Here, we report that while at steady state, T cells are negative for all classes of Fc gamma ...
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作者:Maher, Christina; Tortolero, Lea; Jun, Soyeon; Cummins, Daniel D.; Saad, Adam; Young, James; Martinez, Lizbeth Nunez; Schulman, Zachary; Marcuse, Lara; Waters, Allison; Mayberg, Helen S.; Davidson, Richard J.; Panov, Fedor; Saez, Ignacio