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作者：Kanugovi, Abhijnya; Aguiari, Paola; Choi, Rachel; Kim, Soochi; Wu, Di; De Morree, Antoine; Bui, Summer; Lam, Richard; Biressi, Stefano; Liu, Ling; Rando, Thomas A.
作者单位：Stanford Medicine; Stanford University; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of Trento; Korea University; Aarhus University
摘要：Skeletal muscle fibrosis, as occurs with age, in response to injury, or in the setting of degenerative diseases, results in impairments of muscle regeneration and function. chymal progenitor cells that reside in the muscle interstitium, play a crucial role in normal muscle regeneration by supporting muscle stem cell proliferation. However, in pathological conditions such as severe or recurrent muscle injury, FAPs can aberrantly differentiate into fibrogenic cells, resulting in excessive deposi...
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作者：Ye, Yang; Pandey, Abhishek; Fitzpatrick, Meagan C.; Potter-Schwartz, Lilia; Bawden, Carolyn; Bilori, Bilori; Singer, Burton H.; Galvani, Alison P.
作者单位：Yale University; University System of Maryland; University of Maryland Baltimore; State University System of Florida; University of Florida
摘要：The exorbitant cost of prescription pharmaceuticals is a critical and long-standing concern facing the United States (US). To curb rising drug costs, international reference pricing, aligning drug prices with those in other high-income countries, has emerged as a prominent policy option. We evaluated the potential national savings from such a strategy in the United States through a comprehensive analysis of utilization patterns and global price differentials for over 8,000 drugs. We project an...
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作者：Hsu, Ku-Lung
作者单位：University of Texas System; University of Texas Austin
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作者：Kobayashi, Kyogo S.; Sogabe, Ren; Tatsukawa, Tsuyoshi; Teramae, Jun- Nosuke; Matsuo, Naoki; Nestler, Eric
作者单位：Kyushu University; Kyushu University; Kyoto University
摘要：Associative learning allows animals to learn the predictive relationships between events. Presentation of a conditioned stimulus (CS) preceding an unconditioned stimulus (US) within a short interval associates these events. However, little is known about the neural substrates that represent CSs. By combining in vivo calcium imaging with retrospective identification of dorsal hippocampal CA1 neurons, in which c- fos is induced during contextual fear conditioning in mice, we found that prospecti...
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作者：Liu, Pengchuan; Zhou, Lianjie; Xu, Dian; An, Dongqi; Lu, Yifei; Hu, Bofan; Shao, Yuting; Huang, Ningge; Guo, Chengjie; Chen, Li; Li, Jinbao; Li, Jiahao; Liang, Fuying; Liu, Junhan; Huang, Gaoshan; Mei, Yongfeng; Li, Rui; Song, Enming
作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Dalian University of Technology; Dalian University of Technology; Tongji University; Fudan University; Fudan University; Fudan University
摘要：High-precision in vivo therapeutic technologies that establish three-dimensional (3D), multimodal neural interfaces with targeted biotissues offer significant clinical potential for the timely treatments of localized peripheral nerve injury (PNI). Current approaches for this purpose such as implantable devices face challenges in terms of percutaneous wires and/or nondegradable designs, and support only single-mode operation that lack microscale spatial resolution. Here, we develop a miniaturiz...
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作者：Makarov, Dmitrii E.; Sollich, Peter
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Gottingen; University of London; King's College London
摘要：Molecules in dense environments, such as biological cells, are subjected to forces that fluctuate both in time and in space. While spatial fluctuations are captured by Lifson-Jackson-Zwanzig's model of diffusion in a rough potential, and temporal fluctuations are often viewed as leading to additional friction effects, a unified view where the environment fluctuates both in time and in space is currently lacking. Here, we introduce a discrete-state model of a landscape fluctuating both in time ...
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作者：Wang, Wenchao; Huang, Rongyao; Lv, Longbao; Ma, Xia; Li, Zhenhui; Zhang, Yuhua; Wu, Jing; Wu, Shihao; Xu, Jianglei; Hu, Yingzhou; Turck, Christoph W.; Li, Hao; Hu, Xintian
作者单位：Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Yunnan University; Max Planck Society
摘要：Based mainly on rodents studies, forty-hertz (40-Hz) physical stimulation has been regarded as a potential noninvasive treatment for Alzheimer's disease (AD). Considering the brain differences between rodents and humans, the effects of 40-Hz physical stimulation need to be further validated using nonhuman primates before its clinical application. Here, we took advantage of a rare opportunity to expose nine aged rhesus monkeys (26 to 31 y old) to 40-Hz auditory stimulation. Given the strong cor...
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作者：Yao, Yuxuan; Zhao, Qinyue; Yao, Shun; Xu, Yamei; Liu, Kaien; Cao, Tianyi; Sun, Bo; Zhou, Jingmin; Liu, Cong; Li, Dan
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; ShanghaiTech University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS
摘要：Systemic light chain amyloidosis (AL) is characterized by amyloid fibril deposition in multiple organs, often severely affecting cardiac function. In this study, we extracted amyloid fibrils directly from abdominal fat and cardiac tissue biopsies obtained from three AL patients. Using cryo-electron microscopy, we determined five distinct structures of light chain (LC) amyloid fibrils. Our results demonstrate that LC fibrils from different patients adopt unique structural conformations, highlig...
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作者：Gerchen, John F.; Villamil-Buenrostro, Nora; Li, Xinji; Le Faou, Ehouarn; Pannell, John R.
作者单位：University of Lausanne; Charles University Prague
摘要：The theory of sex allocation is hailed as one of evolutionary biology's great successes. But while it has successfully predicted strategies of resource allocation to male versus female offspring under a wide range of conditions in species with separate sexes, it has been difficult to verify the fundamental assumption of a direct genetic trade-off between male and female allocations when both sexes are expressed together in the same individuals. This trade-off assumption supposes that mutations...
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作者：Lee, Stephen A.; Leconte, Alexis; Wu, Alice; Kinugasa, Joshua; Palacios, Gerardo Ramos; Poree, Jonathan; Sadikot, Abbas F.; Linninger, Andreas; Provost, Jean
作者单位：Universite de Montreal; Polytechnique Montreal; Chiba University; McGill University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Universite de Montreal
摘要：While transcranial neuroimaging of individual capillary function holds transformative potential for diagnostics, it has proven difficult to achieve. Superresolution ultrasound, while capable of achieving micron-scale resolution, relies on the accumulation of multiple microbubble events, a method inherently limited by the exceedingly low probability of observing such events within capillaries. We present single capillary reporters (SCaRe), a paradigm-shifting approach that utilizes the complete...
