2期

最新文章

• Nonsense-mediated decay controls a negative feedback loop in innate immune sensing AI翻译
  作者：Boudreault, Simon; -Lopez, Yahira Rivera; Ferretti, Max B.; Tracey, Matthew A.; Bonner, James; Jacobs, Bertram L.; Lynch, Kristen W.
  作者单位：University of Pennsylvania; Pennsylvania Medicine; Arizona State University; Arizona State University
  摘要：Nonsense-mediated decay (NMD) is an mRNA decay pathway which degrades poten-tial harmful transcripts that contain premature termination codons. However, NMD's importance also extends to the control of isoform abundance under physiological con-ditions. During viral infection, NMD is inhibited through numerous mechanisms; however, NMD has been shown to have both antiviral as well as proviral activities, raising further questions into the role and control of NMD during viral infection. These obse...
• The anticipation of imminent events is time-scale invariant AI翻译
  作者：Grabenhorst, Matthias; Poeppel, David; Michalareas, Georgios
  作者单位：Max Planck Society; New York University; Goethe University Frankfurt
  摘要：Humans predict the timing of imminent events to generate fast and precise actions, decisions, and other behaviors. Such temporal anticipation is critical over wide timescales, and especially salient over the range from hundreds of milliseconds to a few seconds. Despite advances in our understanding of basic timing behavior and its underlying neural mechanisms, it remains an open question whether anticipation is stable across these short time scales. Recent work shows that the brain models the ...
• Enhanced episodic specificity and socioemotional content in older adults' everyday autobiographical thoughts AI翻译
  作者：Rivera, Vannia A. Puig; Andrews, Eric; Cervantes, Leelu J.; Freveletti, Delaney; Huentelman, Matt; Grilli, Matthew D.; Andrews-Hanna, Jessica R.
  作者单位：University of Arizona; Northeastern University; Translational Genomics Research Institute; University of Arizona; University of Arizona
  摘要：Cognitive aging research has long observed that older adults' autobiographical memories and future thoughts, as assessed in laboratory contexts, lack spatiotemporal detail compared to young adults. Does this pattern also hold in everyday contexts? Across two studies, we examined characteristics of autobiographical thinking in real-world settings using ecological momentary assessment (EMA). Study 1 included an adult lifespan sample (N = 3,847). Study 2 (preregistered) included 217 young and old...
• Linking culture and individual behavior: The concept and measurement of cultural consonance AI翻译
  作者：Dressler, William W.
  作者单位：University of Alabama System; University of Alabama Tuscaloosa
  摘要：Culture has been a central concept in the social sciences for well over a century. Yet, a theory of culture with an associated measurement model providing the means to systematically study its effects has proven elusive. Developments in cognitive culture theory over the past several years provide a new perspective and a new set of tools. Culture can be conceptualized as a set of shared cognitive models that encode the information required for individuals to function in a given social setting. ...
• M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT 17 cells in Peyer's patches AI翻译
  作者：Komiyama, Seiga; Kodaira, Yotaro; Maeda, Rae; Sugiura, Yuki; Suzuki, Koichiro; Saeki, Aiko; Kinashi, Yusuke; Oguchi, Hiroyuki; Takano, Kokona; Onawa, Satoshi; Matsui, Ako; Sasaki, Eita; -Muroi, Kisara Hattori; Kimura, Shunsuke; Fujimura, Yumiko; Ka, Yuyo; Ogura, Tomoyuki; Hanaoka, Kenjiro; Ito, Minako; Watarai, Hiroshi; Kaisho, Tsuneyasu; Udagawa, Nobuyuki; Takahashi, Daisuke; Hase, Koji
  作者单位：Keio University; Keio University; Kyoto University; Keio University; Kanagawa Academy Science & Technology; Kyushu University; Keio University; Kanazawa University; Wakayama Medical University; Matsumoto Dental University; Fukushima University; University of Tokyo; Francis Crick Institute; Hokkaido University
  摘要：Interleukin-17-producing gamma delta T cells (gamma delta T17 cells) play a dual role in immune regulation, serving as both protectors in various tissues and orchestrators of inflammatory responses in autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis. However, the ontology and repertoires of encepha-litogenic gamma delta T17 cells remain unclear. In this study, we demonstrate that the encephalitogenicity of gamma delta T17 cell...
• Early life-stage thermal resilience is determined by climate-linked regulatory variation AI翻译
  作者：Nunez, Joaquin C. B.; Tangwancharoen, Sumaetee; Finnegan, Kylie M.; Bufferd, Eliza M.; King, Olin C.; Proud, Luke A.; Lockwood, Brent L.
  作者单位：University of Vermont; Chulalongkorn University; Harvard University
  摘要：The ecological context of developmental physiology remains largely unexplored. We previously showed that thermal selection primarily targets early embryos in Drosophila melanogaster. Here, we used advanced introgression and pooled whole-genome resequencing to map the genomic basis of enhanced embryonic heat tolerance in a neotropical line of D. melanogaster. We identified two loci on chromosomes 2R and X that were consistently targeted by 16 generations of thermal selection across six replicat...
• SARS-CoV-2 peptide fragments selectively dysregulate specific immune cell populations via Gaussian curvature targeting AI翻译
  作者：Zhang, Yue; Silvestre-Roig, Carlos; Fu, Han; Alimohamadi, Haleh; Mandal, Taraknath; Chen, Jonathan W.; Luo, Elizabeth Wei-Chia; de Anda, Jaime; Mato, Anna Livia Linard; Richter, Mathis; Mennella, Anna; Lee, HongKyu; Chan, Liana C.; Wang, Yingrui; Wang, Naixin; Wang, Hongyu; Wang, Xiaohan; Lee, Calvin K.; Ghosh, Susmita; Matsui, Tsutomu; Weiss, Thomas M.; Guo, Tiannan; Zhang, Maomao; Li, Dapeng; Wolfgang, Matthew C.; Hagan, Robert S.; Li, Melody M. H.; Gunzert, Matthiasc; Sickmannt, Albert; Frascal, Loredana; .Yeaman, Michaelr; Landel, Roberto; Cui, Qiang; Soehnleing, Oliver; Wong, Gerard C. . L.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Westlake University; Westlake University; University of Munster; Boston University; Boston University; Boston University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; Harbin Medical University; Westlake University; Westlake University; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Duisburg Essen; Ruhr University Bochum; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center
  摘要：Immune cell populations are dysregulated in COVID-19 for currently unknown reasons: Plasmacytoid dendritic cell (pDC) populations are reduced, thus hampering antiviral responses. CD8(+)T cell populations are reduced, the level of which has emerged as an index of disease severity. Recent work has shown that the proteome of SARS-CoV-2 is a rich reservoir of antimicrobial peptide-like sequence motifs (xenoAMPs) which can chaperone and organize dsRNA for amplified Toll-Like Receptor 3 (TLR3)-media...
• Pathogenic role of MIF receptor (CD74) expressing T cells in inflammatory arthritis AI翻译
  作者：Doherty, Edward; Osmani, Lais; Bilsborrow, Joshua; Par-Young, Jennefer; Choi, Susanna; Tilstam, Pathricia; Shin, Min; Piecychna, Marta; Cai, Helen; Leng, Lin; Kim, Wan-Uk; Kang, Insoo; Bucala, Richard
  作者单位：Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Korea Institute of Oriental Medicine (KIOM); Catholic University of Korea
  摘要：High expression alleles of the innate cytokine, macrophage migration inhibitory factor (MIF), are associated with the development or the severity of autoimmune inflammatory diseases, including rheumatoid arthritis. Numerous studies support MIF's role in activating inflammatory pathways and MIF inhibition reduces joint pathology in different experimental models of arthritis. We examined the impact of gene deletion of MIF or its cognate receptor CD74 in the T cell-dependent model of collagen-ind...
• Chlamydomonas chloroplast genes tolerate compression of the genetic code to just 51 codons AI翻译
  作者：Mordaka, Pawel M.; Clouston, Kitty; Cui, Jing; Holzer, Andre; Jackson, Harry O.; Purton, Saul; Smith, Alison G.
  作者单位：University of Cambridge; University of London; University College London; Saarland University
  摘要：Genome scale engineering has enabled codon compression of the universal genetic code to eliminate seven codons in Escherichia coli, but to allow more radical schemes for codon compression and reassignment to be tested at genome scale, while avoiding significant technical challenges, smaller, simpler genetic systems are needed. Here, we report a recoding scheme for the 205 kb Chlamydomonas reinhardtii chloroplast genome, in which two stop codons and one or more of the codons for arginine, glyci...
• Unveiling a proton-coupled electron-transfer mechanistic library of nitrate to ammonia via ultramicroelectrode-hyphenated mass spectrometry AI翻译
  作者：Zhao, Xiang; Gu, Chaoyue; Liu, Junjie; Kong, Bingjie; Liang, Sen; Tian, Yang; Fu, Hongbing; Shao, Yuanhua
  作者单位：Capital Normal University; Peking University; Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Process Engineering, CAS; Nanjing Institute of Geology & Paleontology, CAS
  摘要：For valuable ammonia synthesis and green nitrogen recycling, electrocatalytic nitrate reduction reaction (NO3RR) presents a sustainable alternative to the conventional Haber-Bosch process. The NO3RR involves intricate, multi-step proton-coupled electron transfers (PCET) featuring multiple nitrogen-oxygen intermediates and reaction branches. Unveiling this complex reaction library is crucial for rational tailoring of NO3RR for improved practical application, yet it remains a formidable challeng...