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作者：Pourshafie, Naemeh; Alexander, Desi C.; Xu, Hong; Yang, Kechun; Donahue, Greg; Lei, Xue; Zhang, Shuo; Shcherbakova, Oksana; Hogan, Connor; Gilbert, Michael; Hoxha, Kevt'her; Chaboub, Lesley; Lee, Virginia M-Y; Adams, Peter D.; Dani, John A.; Bonini, Nancy M.; Berger, Shelley L.
作者单位：University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; University of Pennsylvania; Pennsylvania Medicine; Sanford Burnham Prebys Medical Discovery Institute; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine
摘要：Epigenetic mechanisms, including histone acetylation, regulate learning and memory and underlie Alzheimer's disease and related dementia (ADRD). Acetyl-CoA synthetase 2 (ACSS2), an enzyme generating acetyl-CoA, locally regulates histone acetylation and gene expression in neuronal nuclei. This regulatory mechanism may be a promising target for therapeutic intervention in neurodegenerative diseases. Previously, we showed that systemic ACSS2 knockout mice, although largely normal in physiology, e...
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作者：Turicek, Jack S.; Phillips, Zachary J.; Nakshatrala, Kalyana B.; Patrick, Jason F.
作者单位：North Carolina State University; North Carolina State University; University of Houston System; University of Houston
摘要：Nature's structural composites, such as bone and wood, achieve mechanical performance through hierarchical multimaterial design. Though, their real vantage lies in the exceptional ability to repeatedly heal after damage. Synthetic fiber-reinforced polymer (FRP) composites also leverage material hierarchy via fibrous reinforcement encapsulated within a polymer matrix, maximizing stiffness and strength. However, the layered architecture of laminated FRP composites makes them vulnerable to interl...
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作者：Xu, Yanqi; Jin, Keshuo; Chen, Jiaqing; Li, Zhongding; Zhu, Zhenhu; Su, Xian; Shen, Jiangyun; Zhou, Bincheng; Cao, Zijun; Lou, Liyan; Deng, Deyu; Zhang, Jianzhao; Liu, Baohua; Shentu, Yangping; Wang, Xu
作者单位：Wenzhou Medical University; Oujiang Laboratory; Wenzhou Medical University; Wenzhou Medical University
摘要：Parkinson's disease (PD) is a progressive neurodegenerative disease that casts a significant shadow over global health and the identification of therapeutic targets for PD will empower more effective clinical treatment. The gene encoding the deubiquitinating enzyme USP25 has been identified as a susceptible locus for PD, but the role of USP25 in PD remains unknown. In this study, we found that USP25 exacerbated dopaminergic neuronal loss and motor deficits in murine models of PD by sabotaging ...
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作者：Elliott, Blake L.; O'Brien, Kathleen J.; Fain, Matthew; Ellman, Lauren M.; Murty, Vishnu P.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University; University of Oregon; University of California System; University of California San Diego
摘要：The ability to adapt to a dynamic world relies on detecting, learning, and responding to environmental changes. The detection of novelty serves as a critical indicator of such changes, priming mechanisms to detect and respond to goal-relevant information. However, neural regions that support novelty detection (hippocampus) and goal-directed behavior [dopaminergic midbrain (VTA) and prefrontal cortex (PFC)] have yet to be described as a sequential process that unfolds over time. Using a forward...
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作者：Evans, David; Rosenthal, Yair; Erez, Jonathan; Hauzer, Hagar; Cotton, Laura J.; Zhou, Xiaoli; Nambiar, Romi; Stassen, Peter; Pearson, Paul N.; Renema, Willem; Saraswati, Pratul Kumar; Todd, Jonathan A.; Muller, Wolfgang; Affek, Hagit P.
作者单位：NERC National Oceanography Centre; University of Southampton; Rutgers University System; Rutgers University New Brunswick; Tongji University; Hebrew University of Jerusalem; Israel Oceanographic & Limnological Research Institute; Rutgers University System; Rutgers University New Brunswick; Goethe University Frankfurt; KU Leuven; Royal Belgian Institute of Natural Sciences; University of London; Birkbeck University London; Naturalis Biodiversity Center; University of Amsterdam; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Natural History Museum London
摘要：A similar to fivefold decrease in the atmospheric concentration of CO2 took place during the Cenozoic. This has often been viewed within the context of silicate weathering changes, although the specific contributions of the potential drivers remain poorly understood. Indeed, it has been alternatively argued that changes in the sea floor spreading rate contributed to the Cenozoic pCO(2) decline, although the magnitude of the decrease means that this is unlikely to account for the entirety of th...
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作者：McDermott, Amy
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作者：Su, Jie; Cai, Fang; Zhao, Shu-Kuo; Wang, Xin-Yi; Qian, Tian-Yi; Wang, Da-Hui; Hong, Bo
作者单位：Qiyuan Laboratory; Beijing Normal University; Beijing Normal University
摘要：The human brain excels at complex tasks with remarkable efficiency, adaptability, and resilience, making it a powerful source of inspiration for AI. Here, we present a neural dynamics model inspired by the primate dorsal visual pathway, a circuit crucial for motion and spatial processing. Incorporating key neuronal and synaptic dynamics, the model reproduces human-like decision-making behaviors and neural activity patterns without the need for extensive training. Compared with conventional art...
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作者：Yang, Jingrui; Van Groenigen, Kees Jan; Meng, Jun; Yan, Xiaoyuan; Xiaa, Longlong
作者单位：Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Exeter
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作者：Foote, Andrew D.
作者单位：University of Oslo
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作者：Freitas, Carla
