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作者：Rosenwasser, Zohar; Cohen-Fultheim, Roni; Levitt, Michael; Levanon, Erez Y.; Oren, Gal
作者单位：Stanford Medicine; Stanford University; Technion Israel Institute of Technology
摘要：Adenosine-to-inosine (A-to-I) RNA editing by ADAR enzymes shapes transcript fate and underpins emerging RNA editing therapeutics, yet predicting which adenosines are edited remains difficult. We introduce ADAR-GPT, a model-agnostic fine-tuning framework that adapts a GPT-class language model to classify editing at candidate sites using sequence context in standardized 201 nt windows with the target adenosine explicitly marked. We train and evaluate on GTEx liver data (n = 131 samples) at a cli...
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作者：Zhao, Yuxi; Tong, Man; Tian, Li; Luo, Genming; Li, Ping; Song, Haijun; Chen, Zhong-qiang; Xie, Shucheng; Kappler, Andreas; Yuan, Songhu
作者单位：China University of Geosciences; Eberhard Karls University of Tubingen
摘要：The great phytoplanktonic shift from green to red plastid lineage dominance in the early Mesozoic marks a primary producer revolution in marine ecosystems, facilitating the rise of modern ecosystems and impacting global carbon cycling and energy flows. The causes driving this evolutionary transition have been attributed to the changes in essential nutrients and the environmental crises of the Permian-Triassic mass extinction. Nonetheless, the underlying mechanisms driving this transition remai...
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作者：Ansaldo, Eduard; Yong, Daniel; Carrillo, Nathan; McFadden, Taryn; Abid, Mahnoor; Corral, Dan; Rivera, Claudia; Farley, Taylor; Bouladoux, Nicolas; Gribonika, Inta; Belkaid, Yasmine
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; University of Pennsylvania; Pennsylvania Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; University System of Maryland; University of Maryland Baltimore; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Lund University
摘要：Intestinal immunity defends against enteric pathogens, mediates symbiotic relationships with the resident microbiota, and provides tolerance to food antigens, safeguarding critical nutrient absorption and barrier functions of this mucosal tissue. Despite the abundance of tissue resident activated T cells, their contributions to these various roles remain poorly understood. Here, we identify a dominant population of IL-10 producing, T-bet-expressing Tr1 T cells, residing in the small intestinal...
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作者：Edmonsond, Stacey; Dyer, Blake
作者单位：University of Victoria
摘要：The rise of atmospheric oxygen during the Great Oxidation Event (GOE) (ca. 2.5 to 2.1 billion years ago) permanently transformed Earth's biogeochemical cycles. The chemistry of contemporaneous marine carbonates provides a window into operation of the carbon cycle across this transition. Specifically, carbonate rocks co-eval with the GOE preserve a large and long-lived positive carbon isotope (delta C-13) excursion, the Lomagundi-Jatuli excursion (LJE), that canonically is interpreted as an inc...
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作者：Su, Zhi -Fei; Wu, Chen -Zhou; Ding, Hao -Ran; Zhan, Qi; Ba, Yong -Bing; Cheng, Lei; Li, Ji -Yao; Zhou, Xue -Dong; Li, Long -Jiang; Zhang, Li -Xin; Li, Jing; Li, Yi; Ren, Biao
作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; East China University of Science and Technology; Tianfu Jiangxi Laboratory
摘要：Head and neck squamous cell carcinoma (HNSCC) involves aggressive invasion at the tumor-host interface, particularly at the leading edge. However, the mechanisms sustaining this invasive front remain unclear. Here, we performed spatially resolved multiomics profiling to characterize the leading-edge multicellular ecosystem (LEMCE) of HNSCC. We identified a set of twelve autocrine ligands, including TGFB1, ICAM1, and TNC, that support a stable invasive transcriptional state. Impaired fatty acid...
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作者：Wan, Xuan; Cohen, Sarah M.; Yu, Yan; Le, Henry Hoan; Park, Heenam; Groaz, Alessandro; Moreno, Rachel; Tan, Minyi; Schneider, Jessica; Gronquist, Matthew R.; Shinya, Ryoji; Schroeder, Frank C.; Sternberg, Paul W.
作者单位：California Institute of Technology; Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Mount Holyoke College; State University of New York (SUNY) System; SUNY Fredonia; Meiji University
摘要：Gene family expansions are critical for functional diversification, yet the contributions of paralogs to metabolic pathways are often unclear. In Caenorhabditis, the expanded O-acyltransferase (OAC) family-enzymes that transfer acyl groups to hydroxylated substrates-remains poorly characterized despite having been implicated in lipid metabOAC-family protein-coding genes to define their roles in regulating signaling molecules. We found that four adjacent paralogs (oac-13, oac-16, oac-25, and oa...
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作者：Zhu, Biyue; Liu, Zhenhua; Van, Richard; Wang, Huizhe; Kuang, Shi; Jia, Yuntao; Leon, Erick Calderon; Yang, Fan; Zhang, Jing; Yang, Jun; Hong, Howard; Lobo, Fleur; Yu, Astra; Wang, Johnson; Tanzi, Rudolph E.; Zhang, Can; Mao, Xiaobo; Shao, Yihan; Ran, Chongzhao
作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Chongqing Medical University; Central South University; University of Oklahoma System; University of Oklahoma - Norman; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Johns Hopkins University; Johns Hopkins Medicine
摘要：Protein misfolding in the brain is a key pathological hallmark of neurodegenerative diseases. Optical imaging of misfolded proteins in disease models is essential for elucidating etiology and early diagnosis. However, developing specific optical imaging probes for each misfolded protein is time-consuming and challenging, leaving many pathological targets without effective detection tools, especially for in vivo imaging. Here, we present a dual-mode chemiluminescence strategy that enables both ...
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作者：Chu, Yun-Hui; Zhang, Lu-Yang; He, Jia-Yi; Wang, Ya-Fang; Dong, Ming-Hao; You, Yun-Fan; Pang, Xiao-Wei; Zhu, Li-Fang; Zhang, Hang; Xu, Lu-Lu; Chen, Lian; Zhou, Luo-Qi; Xiao, Jun; Shang, Ke; Gong, Jian-Ke; Wang, Wei; Tian, Dai-Shi; Qin, Chuan
作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology
摘要：Ischemic white matter damage is a significant pathological feature of chronic cerebral hypoperfusion, leading to cognitive impairments. However, the underlying molecular mechanisms remain poorly understood. In this study, we identify a causal association between genetically predicted extracellular signal-regulated kinase 5 (ERK5) expression and higher white matter hyperintensity volume through druggable target screening, suggesting its potential as a therapeutic target for white matter damage....
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作者：Fields, Eviatar; Rogers, Ben C.; Leung, Tsz Chui Sophia; Huang, Andy; Kern, Megan; Kontowicz, Nell; Dolin, Hannah; Watt, Alanna J.
作者单位：McGill University; McGill University
摘要：Aging is associated with the decline of many bodily functions including motor coordination. Aging-related impairment in motor coordination can result in falls, which reduce independence, health span, and quality of life in the elderly. To study the neural mechanisms that underlie this decline, we studied aged mice and observed a progressive decline in motor coordination on multiple motor coordination assays. The cerebellum is critically involved in motor coordination and balance, and cerebella...
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作者：Mondal, Susanta; Kundu, Madhuchhanda; Jana, Malabendu; Roy, Avik; Modi, Khushbu K.; Albalawi, Yasmeen A.; Pahan, Kalipada
