2期

最新文章

• Network structure shapes consensus dynamics through individual decisions AI翻译
  作者：Priniski, J. Hunter; Linford, Bryce; Hirschmann, Anna; Venumuddala, Sai Krishna; Morstatter, Fred; Rodriguez, Nancy; Brantingham, P. Jeffrey; Lu, Hongjing
  作者单位：University of California System; University of California Los Angeles; University of Colorado System; University of Colorado Boulder; University of Southern California; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：How do shared narratives emerge in decentralized online networks? Prior research using simplified group coordination tasks (e.g., face-naming) shows network structure shapes group consensus, but the underlying cognitive mechanisms remain unclear. Here, we examine how network structure influences the emergence and semantic content of shared narrative beliefs in experimental online social networks, using natural language processing measures and agent-based modeling. Media content with complex ca...
• Reconstructing the early spatial spread of pandemic respiratory viruses in the United States AI翻译
  作者：Zhang, Renquan; Deng, Rui; Liu, Sitong; Yao, Qing; Shaman, Jeffrey; Grenfell, Bryan T.; Viboud, Cecile; Pei, Sen
  作者单位：Dalian University of Technology; Columbia University; Columbia University; Princeton University; National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC)
  摘要：Understanding the geographic spread of emerging respiratory viruses is critical for pandemic preparedness, yet the early spatiotemporal dynamics of the 2009 H1N1 pandemic influenza and severe acute respiratory syndrome coronavirus 2 in the United States remain unclear. While mobility and genomic data have revealed important aspects of pandemic spatial spread, several key questions remain: Did the two pandemics follow similar spatial transmission routes? How rapidly did they spread across the U...
• Mutation rate variability in viral populations: Implications for lethal mutagenesis AI翻译
  作者：Arcos, Sarah; Lauring, Adam S.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Lethal mutagenesis is a strategy to achieve viral extinction by drugging viral mutation rates beyond an extinction threshold. Accurate estimation of the extinction threshold is critical, as elevating viral mutation rates near, but not past this threshold increases the likelihood of mutations that could result in drug resistance, vaccine escape, or increased pathogenesis. Traditional models of lethal mutagenesis rely on the Poisson distribution, which assumes a uniform mutation rate across indi...
• Primate gut microbiota induce evolutionarily salient changes in mouse neurodevelopment AI翻译
  作者：Decasien, Alex R.; Aronoff, Jacob E.; Mallott, Elizabeth K.; Kuthyar, Sahana; Chitta, Sriram; Layden, Brian T.; Sardaro, Maria L. Savo; Gray, Stanton; Williams, Lawrence E.; Liechty, Emma R.; Lee, Hyo M.; Lee, Won; Curley, James P.; Kuzawa, Christopher W.; Amato, Katherine R.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); New York University; Arizona State University; Arizona State University-Tempe; Northwestern University; Washington University (WUSTL); University of California System; University of California San Diego; University of Texas System; UTMD Anderson Cancer Center; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; Northwestern University; Feinberg School of Medicine; University of Texas System; University of Texas Austin; Jackson Laboratory; Harvard University
  摘要：Multiple primate species, including humans, evolved brains that are exceptionally large relative to their body sizes. These large brains coevolved with metabolic adaptations that enhance cerebral energy supply, including increased circulating glucose levels. While the gut microbiota (GM) is known to influence host metabolism, its potential role in primate brain evolution remains unclear. To investigate this, we inoculated germ-free mice with the GMs of primate species selected to separate the ...
• Mesoscale imaging of the human cerebellum reveals converging regional specialization of its morphology, vasculature, and cytoarchitecture AI翻译
  作者：Priovoulos, Nikos; Bazin, Pierre-Louis; Brouwer, Emma J. P.; Mejias, Jorge F.; de Buck, Matthijs H. S.; Alkemade, Anneke; van der Zwaag, Wietske; Caan, Matthan W. A.
  作者单位：University of Amsterdam; Royal Netherlands Academy of Arts & Sciences; Spinoza Centre for Neuroimaging (KNAW); University of Oxford; Maastricht University; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute for Neuroscience (NIN-KNAW); University of Amsterdam; University of Amsterdam; University of Amsterdam
  摘要：The human cerebellar cortex, despite containing the majority of the brain's neurons, remains poorly characterized in vivo due to its extreme folding and thin laminar architecture. Here, we present a high-resolution imaging framework based on parallel-transmit, motion-corrected, ultra-high-field (7T) MRI paired with an automated, anatomically faithful cerebellar segmentation pipeline. This enables detailed quantification of cerebellar morphology and vascular architecture at scales previously in...
• Multimetallic synergies in tandem plasmonic photocatalysis AI翻译
  作者：Swearer, Dayne F.
  作者单位：Northwestern University; Northwestern University; Northwestern University
• Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection AI翻译
  作者：Verma, Abhishek Kumar; Tan, Lu; Schuster, Noah; Moye, Skyler L.; Lin, Li-Chun; Lowery, Shea; Duraisami, Eazhisaivallabi; Llorens, Juan E. Abrahante; Qiu, Qiang; Hefti, Marco; Meyerholz, David K.; Coleman, Mitchell C.; Yu, C. Ron; Albers, Mark W.; Perlman, Stanley
  作者单位：University of Iowa; University of Iowa; University of Iowa; University of Minnesota System; University of Minnesota Twin Cities; Stowers Institute for Medical Research; University of Iowa; University of Iowa; University System of Ohio; Case Western Reserve University; Harvard University; Harvard Medical School
  摘要：Post-acute sequelae of COVID-19 (PASC) encompasses persistent neurological disease, including olfactory and cognitive dysfunction. The basis for this dysfunction is poorly understood. Here, we report neurological dysfunction for at least 120 d postinfection in mice infected with a virulent nonneurotropic mouse-adapted SARS-CoV-2. Long after recovery from nasal infection, we observed diminished tyrosine hydroxylase expression in olfactory bulb glomeruli and in substantia nigra. Similar changes ...