-
作者：Theeuwen, Tom P. J. M.; Wijfjes, Raul Y.; Dorussen, Delfi; Lawson, Aaron W.; Lind, Jorrit; Jin, Kaining; Boekeloo, Janhenk; Tijink, Dillian; Hall, David; Hanhart, Corrie; Becker, Frank F. M.; van Eeuwijk, Fred A.; Kramer, David M.; Wijnker, Erik; Harbinson, Jeremy; Koornneef, Maarten; Aarts, Mark G. M.
作者单位：Wageningen University & Research; Wageningen University & Research; Michigan State University; Wageningen University & Research; Wageningen University & Research; University of Munich; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; Max Planck Society; Wageningen University & Research; Wageningen University & Research
摘要：Efforts to improve photosynthetic performance are increasingly employing natural genetic variation. However, genetic variation in the organellar genomes (plasmotypes) is often disregarded due to the difficulty of studying the plasmotypes and the lack of evidence that this is a worthwhile investment. Here, we systematically phenotyped plasmotype diversity using Arabidopsis thaliana as a model species. A reanalysis of whole- genome resequencing data of 1,541 representative accessions shows that ...
-
作者：Bringas, Fernando R. Rosas; Yin, Ziqing; Yao, Yue; Boudeman, Jonathan; Ollivaud, Sandra; Chang, Michael
作者单位：University of Groningen
摘要：Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being at chromosome ends, telomere repeats are also present at internal locations within chromosomes, known as interstitial telomeric sequences (ITSs). These sequences are unstable and prone to triggering gross chromosomal rearrangements (GCRs). In this study, we quantitatively examined the effect of ITSs on the GCR ...
-
作者：Hwang, Hyeona; Lim, Yookyung; Oh, Myung - Min; Choi, Hyunmo; Shim, Donghwan; Song, Young Hun; Cho, Hyunwoo
作者单位：Chungbuk National University; Chungbuk National University; National Institute of Forest Science (NIFOS), Republic of South Korea; Korea Forest Research Institute (KFRI); Chungnam National University; Seoul National University (SNU)
摘要：Plants have evolved photoreceptors to optimize their development during primary growth, including germination, hypocotyl elongation, cotyledon opening, and root growth, allowing them to adapt to challenging light conditions. The light signaling transduction pathway during seedling establishment has been extensively studied, but little molecular evidence is available for light- regulated secondary growth, and how light regulates cambium- derived tissue production remains largely unexplored. Her...
-
作者：Susperreguy, Sebastian; Yamashita, Megumi; Choi, Chan-il; Liao, Yanhong; Burch, Lauranell H.; Blankenship, Terry L.; Hayes, Erika; Sliwa, Thomas; Zhang, Yingpei; Grenet, Dagoberto; Walker, Mitzie; Plummer, Nicholas W.; Abramowitz, Joel; Kinet, Jean Pierre; Formoso, Karina; Johnson, Brandon E.; Fleig, Andrea; Hazlehurst, Lori; Penner, Reinhold; Freichel, Marc; Flockerzi, Veit; Prakriya, Murali; Birnbaumer, Lutz
作者单位：Pontificia Universidad Catolica Argentina; Northwestern University; Feinberg School of Medicine; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Huazhong University of Science & Technology; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; The Queen's Medical Center; University of Hawaii System; Cancer Research Center of Hawaii; University of Hawaii System; West Virginia University; Saarland University; Ruprecht Karls University Heidelberg
摘要：Using genetically engineered mice and cell lines derived from genetically engineered mice depend obligatorily on functionally intact TRPC molecules, as SOCE monitored with have been structurally and functionally inactivated. Unexpectedly as well, we found that unaffected by ablation of all seven TRPC genes. We refer to mice and cells carrying the seven- fold disruption of TRPC genes as TRPC heptaKO mice and cells. TRPC heptaKO mice are fertile allowing the creation of a new homozygous inbred s...
-
作者：Trentin, Caterina; Falanga, Luigi; Jeske, Jannik; Olivers, Christian N. L.; Slagter, Heleen A.
作者单位：Vrije Universiteit Amsterdam
摘要：Visual working memory (VWM) retains representations of past visual information for future action. Yet to date, most studies have approached VWM as just serving perception beyond the immediate. Whether and how prospective actions shape information in VWM remains largely unknown, in part because typical experimental setups limit behavior to simple button presses. In two experiments (one preregistered), using a novel interactive VWM task, we show that the similarity of the actions that we intend ...
-
作者：Vankuren, Nicholas W.; Kronforst, Marcus R.
作者单位：University of Chicago
-
作者：Bateman, Ian J.; Binner, Amy; Addicott, Ethan T.; Balmford, Ben; Cho, Frankie H. T.; Daily, Gretchen C.; De-Gol, Anthony; Eisenbarth, Sabrina; Faccioli, Michela; Ferguson-Gow, Henry; Ferrini, Silvia; Fezzi, Carlo; Gannon, Kate; Groom, Ben; Harper, Anna B.; Harwood, Amii; Hillier, Jon; Hulme, Mark F.; Lee, Christopher F.; Liuzzo, Lorena; Lovett, Andrew; Mancini, Mattia C.; Matthews, Robert; Morison, James I. L.; Owen, Nathan; Pearson, Richard G.; Polasky, Stephen; Siriwardena, Gavin; Smith, Pete; Snowdon, Pat Pat; Tippett, Peter; Vetter, Sylvia H.; Vinjili, Shailaja; Vossler, Christian A.; Watson, Robert T.; Williamson, Daniel; Day, Brett H.
作者单位：University of Exeter; Stanford University; University of East Anglia; University of St Gallen; University of Trento; University of London; University College London; University of Trento; University of London; London School Economics & Political Science; University System of Georgia; University of Georgia; University of Edinburgh; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Roslin Institute; British Trust for Ornithology; University of Minnesota System; University of Minnesota Twin Cities; University of Aberdeen; University of Exeter; University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville
摘要：Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek et al., Science 376, 1416-1421 (2022)]. The interconnected and spatially varying nature of the impacts of land use change means that these challenges must be addressed simultaneously [H.- O. P & ouml;rtner et al., Science 380, eabl4881 (2023)]. However, governments commonly focus on single issues, incentivizing land use change via Flat- Rate subsidies...
-
作者：Chu, Fengyun; Hou, Peili; Zhu, Hongchao; Gao, Yan; Wang, Xiaomeng; He, Wenqi; Ren, Juan; Li, Min; Liu, Yu; He, Daniel Chang; Wang, Hongmei; Gao, Yuwei; He, Hongbin
作者单位：Shandong Normal University; Shandong Agricultural University; Jilin University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Chinese Academy of Agricultural Sciences
摘要：Phenazine biosynthesis- like domain- containing protein (PBLD) has been reported to be involved in the development of many cancers. However, whether PBLD regulates innate immune responses and viral replication is unclear. In this study, although it was found that the activity of PBLD extends to other PRRs, we focused on the RLR pathway activated via the p53-USP4-MAVS axis in response to virus infections. We found that PBLD deubiquitinates and stabilizes MAVS through ubiquitin- specific proteas...
-
作者：Johnson, Martin T.; Gudlur, Aparna; Zhang, Xuexin; Xin, Ping; Emrich, Scott M.; Yoast, Ryan E.; Courjaret, Raphael; Nwokonko, Robert M.; Li, Wei; Hempel, Nadine; Machaca, Khaled; Gill, Donald L.; Hogan, Patrick G.; Trebak, Mohamed
-
作者：Klein, Eili Y.; Impalli, Isabella; Poleon, Suprena; Denoel, Philippe; Cipriano, Mariateresa; Boeckel, Thomas P. Van; Pecetta, Simone; Bloom, David E.; Nandi, Arindam
作者单位：Johns Hopkins University; Johns Hopkins Medicine; GlaxoSmithKline; GlaxoSmithKline; University of Zurich; Universite Libre de Bruxelles; Harvard University; Harvard T.H. Chan School of Public Health; Population Council
摘要：Antibiotic resistance is a global public health threat. Many factors contribute to this issue, with human antibiotic consumption being significant among them. Analyzing trends and patterns in consumption can aid in developing policies to mitigate the burden of antimicrobial resistance and global disparities in access to antibiotics. Using pharmaceutical sales data licensed from IQVIA, we estimate national- level trends in antibiotic consumption in 67 countries during 2016-2023 and analyze the ...
