49期

最新文章

• BCL2 regulates antibacterial autophagy in the intestinal epithelium AI翻译
  作者：Li, Yun; Bel, Shai; Benjamin, Jamaal L.; Ruhn, Kelly A.; Hassell, Brian; Behrendt, Cassie L.; Kuang, Zheng; Hooper, Lora, V
  作者单位：Bar Ilan University; University of Texas System; University of Texas Southwestern Medical Center; Carnegie Mellon University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
  摘要：Autophagy is a key innate immune defense mechanism in intestinal epithelial cells. Bacterial invasion of epithelial cells activates antibacterial autophagy through a process that requires the innate immune adaptor protein MYD88, yet how MYD88 signaling connects to the autophagy machinery is unknown. Here, we show that the mouse intestriggers MYD88 signaling that regulates binding of the anti- autophagy factor B cell lymcomplex and releasing BECN1 to initiate autophagy. Mice with BCL2 phosphory...
• Staggered immunization with mRNA vaccines encoding SARS- CoV-2 polymerase or spike antigens broadens the T cell epitope repertoire AI翻译
  作者：Abt, Evan R.; Lam, Alex K.; Noguchi, Miyako; Rashid, Khalid; Mclaughlin, Jami; Teng, Pu - Lin; Tran, Wendy; Cheng, Donghui; Nesterenko, Pavlo A.; Mao, Zhiyuan; Creech, Amanda L.; Sojo, Giselle Burton; Jeyachandran, Arjit Vijey; Tam, Ying K.; Henley, Jill E.; Comai, Lucio; Pardi, Norbert; Arumugaswami, Vaithilingaraja; Witte, Owen N.; Radu, Caius G.; Wu, Ting- Ting
  作者单位：University of California System; University of California Los Angeles; University of Southern California; University of Pennsylvania; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
  摘要：Combining a T cell- targeting mRNA vaccine encoding the conserved SARS-CoV-2 RNA- dependent RNA polymerase, RdRp, with a Spike- encoding mRNA vaccine may offer an additional pathway toward COVID-19 protection. Here, we show that a nucleoside- modified RdRp mRNA vaccine raises robust and durable CD8+ T cell responses in mice. Immunization drives a CD8+ T cell response enriched toward a specific RdRp epitope. Unexpectedly, coadministration of mRNA vaccines encoding RdRp or the Spike Receptor Bin...
• The July 2024 Trump assassination attempt was followed by lower in-group support for partisan violence and increased group unity AI翻译
  作者：Holliday, Derek E.; Lelkes, Yphtach; Westwood, Sean J.
  作者单位：Stanford University; University of Pennsylvania; Dartmouth College
  摘要：The attempted assassination of Donald Trump led to widespread concern that the event would escalate political violence between U.S. partisans. While some politicians pleaded for Americans to unite against political violence and turn down the temperature on partisan hostility, others continued to engage in inflammatory rhetoric and blame. Using a national survey in the field at the time of the assassination attempt, we take the temperature of America's partisans before and after the event. We e...
• ER- tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis AI翻译
  作者：Kim, Hyunbae; Chen, Qi; Ju, Donghong; Purandare, Neeraja; Chen, Xuequn; Samavati, Lobelia; Li, Li; Zhang, Ren; Grossman, Lawrence I.; Zhang, Kezhong
  作者单位：Wayne State University; Wayne State University; Wayne State University
  摘要：The Mitochondrial Unfolded Protein Response (UPRmt), a mitochondria- originated stress response to altered mitochondrial proteostasis, plays important roles in various pathophysiological processes. In this study, we revealed that the endoplasmic reticulum (ER)- tethered stress sensor CREBH regulates UPRmt to maintain mitochondrial homeostasis and function in the liver. CREBH is enriched in and required for hepatic Mitochondria- Associated Membrane (MAM) expansion induced by energy demands. Und...
• Metamorphism in a wet Martian middle crust AI翻译
  作者：Palin, Richard; Wade, Jon; Dyck, Brendan
  作者单位：University of Oxford; University of British Columbia
• Pharmacological inhibition of HIF2 protects against bone loss in an experimental model of estrogen deficiency AI翻译
  作者：Lanzolla, Giulia; Sabini, Elena; Beigel, Katherine; Khan, Mohd Parvez; Liu, Xiaowei Sherry; Wang, Dian; Laslow, Brittany; Taylor, Deanne; Bellido, Teresita; Giaccia, Amato; Schipani, Ernestina
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Arkansas System; University of Arkansas Little Rock; University of Arkansas Fayetteville; US Department of Veterans Affairs; Veterans Health Administration (VHA); Central Arkansas Veterans Healthcare System; University of Oxford
  摘要：Estrogen deficiency, which is linked to various pathological conditions such as primary ovarian insufficiency and postmenopausal osteoporosis, disrupts the delicate balance between bone formation and resorption. This imbalance leads to bone loss and an increased risk of fractures, primarily due to a significant reduction in trabecular bone mass. Trabecular osteoblasts, the cells responsible for bone formation within the trabecular compartment, originate from skeletal progenitors located in the...
• AtFH5 recruits and transports the arabinogalactan protein AGP23 to maintain the tip growth of pollen tube AI翻译
  作者：Li, Jiang; Fan, Ligang; Yang, Ting; Zhang, Puzhi; Ruan, Huaqiang; Li, Yihao; Wang, Ting; Zhang, Yi; Zhang, Fanfan; Ren, Haiyun
  作者单位：Beijing Normal University; Beijing Normal University
  摘要：Actin cytoskeleton drives the targeted transport of cell wall components to sustain the tip growth of pollen tubes for double fertilization; however, the underlying mechanism remains largely unknown. Arabidopsis formin 5 (AtFH5), an actin-nucleating protein, localizes at secretory vesicles and mediates actin polymerization-based vesicle trafficking in pollen. Here, we demonstrate that AtFH5 determines the recruitment and transport of cell wall components in AtFH5-labeled vesicles during the ti...
• Flexible bioelectronic systems with large- scale temperature sensor arrays for monitoring and treatments of localized wound inflammation AI翻译
  作者：Liu, Junhan; Li, Zhongzheng; Sun, Mubai; Zhou, Lianjie; Wu, Xiaojun; Lu, Yifei; Shao, Yuting; Liu, Chang; Huang, Ningge; Hu, Bofan; Wu, Zhongyuan; You, Chunyu; Li, Lizhu; Wang, Ming; Tao, Ling; Di, Zengfeng; Sheng, Xing; Mei, Yongfeng; Song, Enming
  作者单位：Fudan University; Fudan University; Fudan University; Fudan University; Fudan University; Jilin Academy of Agricultural Sciences; Tongji University; University of Electronic Science & Technology of China; University of Electronic Science & Technology of China; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Microsystem & Information Technology, CAS; Tsinghua University; Tsinghua University
  摘要：Continuous monitoring and closed- loop therapy of soft wound tissues is of particular interest in biomedical research and clinical practices. An important focus is on the development of implantable bioelectronics that can measure time- dependent temperature distribution related to localized inflammation over large areas ofwound and offer in situ treatment. Existing approaches such as thermometers/thermocouples provide limited spatial resolution, inapplicable to a wearable/implantable format. H...
• Magnetic soft microrobots for erectile dysfunction therapy AI翻译
  作者：Wang, Shuting; Wang, Zhenqing; Shen, Zongshan; Zhang, Min; Jin, Dongdong; Zheng, Ke; Liu, Xuemin; Chai, Muyuan; Wang, Zhenxing; Chi, Ani; Ostrovidov, Serge; Wu, Hongkai; Shao, Dan; Liu, Guihua; Wu, Kai; Leong, Kam W.; Shi, Xuetao
  作者单位：South China University of Technology; South China University of Technology; South China University of Technology; Shandong First Medical University & Shandong Academy of Medical Sciences; Sun Yat Sen University; Sun Yat Sen University; Harbin Institute of Technology; Dongguan University of Technology; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Hong Kong University of Science & Technology; South China University of Technology; Columbia University; Sun Yat Sen University
  摘要：Erectile dysfunction (ED) is a major threat to male fertility and quality of life, and mesenchymal stromal cells (MSCs) are a promising therapeutic option. However, therapeutic outcomes are compromised by low MSC retention and survival rates in corpus cavernosum tissue. Here, we developed an innovative magnetic soft microrobot comprising an ultrasoft hydrogel microsphere embedded with a magnetic nanoparticle chain for MSC delivery. This design also features phenylboronic acid groups for scaven...
• Long- term stability of productivity increases with tree diversity in Canadian forests AI翻译
  作者：Ding, Xiaxia; Reich, Peter B.; Hisano, Masumi; Chen, Han Y. H.
  作者单位：Lakehead University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Minnesota System; University of Minnesota Twin Cities; Hiroshima University
  摘要：The temporal stability of forest productivity is a key ecosystem function and an essential service to humanity. Plot- scale tree diversity experiments with observations over 10 to 11 y indicate that tree diversity increases stability under various environmental changes. However, it remains unknown whether these small- scale experimental findings are relevant to the longer- term stability of natural forests. Using 7,500 natural forest plots across much of Canada, monitored over three to four de...