49期

最新文章

• Cultural tightness and resilience against environmental shocks in nonindustrial societies AI翻译
  作者：Tverskoi, Denis; Ember, Carol R.; Gelfand, Michele J.; Jones, Eric C.; Skoggard, Ian; Toutee, Louise; Gavrilets, Sergey
  作者单位：University of Tennessee System; University of Tennessee Knoxville; University of Tennessee System; University of Tennessee Knoxville; University System of Ohio; Ohio State University; Yale University; Stanford University; Stanford University; University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; University of Tennessee System; University of Tennessee Knoxville
  摘要：With climate change intensifying, building resilience against climate-related shocks is now a global imperative. Historically, many societies have faced natural hazards, with some adapting through specific social and cultural practices. Understanding these responses is key to developing modern sustainability strategies. Here, we address this issue by developing a mathematical model explicitly accounting for various environmental shock dimensions, cooperative activities common in nonindustrial ...
• Nanoscale dynamics of Dynamin 1 helices reveals squeeze-twist deformation mode critical for membrane fission AI翻译
  作者：Zhang, Yuliang; Lillo, Javier Vera; Abdelrasoul, Mahmoud Shaaban Mohamed; Wang, Yaqing; Arrasate, Pedro; Frolov, Vadim A.; Noy, Aleksandr
  作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory; Consejo Superior de Investigaciones Cientificas (CSIC); University of Basque Country; CSIC - UPV EHU - Instituto Biofisika; University of Basque Country; Basque Foundation for Science; University of California System; University of California Merced; Barcelona Institute of Science & Technology; Universitat Politecnica de Catalunya; Institut de Ciencies Fotoniques (ICFO); Egyptian Knowledge Bank (EKB); Assiut University
  摘要：Dynamin 1 (Dyn1) GTPase, a principal driver of membrane fission during synaptic endocytosis, self-assembles into short mechanoactive helices cleaving the necks of endocytic vesicles. While structural information about Dyn1 helix is abundant, little is known about the nanoscale dynamics of the helical scaffolding at the moment of fission, complicating mechanistic understanding of Dyn1 action. To address the role of the helix dynamics in fission, we used High-Speed Atomic Force Microscopy (HS-AF...
• CB1R activates the epilepsy- associated protein Go to regulate neurotransmitter release and synaptic plasticity in the cerebellum AI翻译
  作者：Choi, Jung-Mi; Acharya, Rakshya; Cha, Hye Lim; Lee, Kwang-Wook; Seo, Jewoo; Yang, Esther; Kim, Hyun; Yoon, Jong Hyuk; Chang, Da-Young; Kim, Sung-Soo; Kim, Sang Jeong; Birnbaumer, Lutz; Suh-Kim, Haeyoung
  作者单位：Ajou University; Seoul National University (SNU); Korea University; Korea University Medicine (KU Medicine); Korea Brain Research Institute (KBRI); Pontificia Universidad Catolica Argentina; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Ajou University
  摘要：GNAO1 encodes the alpha subunit of the heterotrimeric Go protein. Despite being the most abundant G protein at synapses, the role of Go in the brain remains unclear, primarily because of the high mortality associated with developmental and epileptic encephalopathy (DEE) 17 in Gnao1 mutated animals. Here, we conducted proteomic analyses with a brain synaptosomal fraction to investigate the Go- interactome and then generated a non-DEE model using Gli1 CreERT2 mice to selectively knockout (KO) th...
• Phase separation of planetary ices explains nondipolar magnetic fields of Uranus and Neptune AI翻译
  作者：Militzer, Burkhard
  作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：The Voyager spacecraft discovered that the ice giants Uranus and Neptune have nondipolar magnetic fields, defying expectations that a thick interior layer of planetary ices would generate strong dipolar fields. Stanley and Bloxham showed that nondipolar fields emerge if the magnetic field is only generated in a thin outer layer. However, the origin and composition of this dynamo active layer has so far remained elusive. Here, we show with ab initio computer simulations that a mixture of H2O, C...
• Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis AI翻译
  作者：Lanz, Tobias V.; Robinson, William H.
  作者单位：Stanford University; Stanford University; Geriatric Research Education & Clinical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care System
• Molecular insights into the interaction between a disordered protein and a folded RNA AI翻译
  作者：Mitra, Rishav; Usher, Emery T.; Dedeoglu, Selin; Crotteau, Matthew J.; Fraser, Olivia A.; Yennawar, Neela H.; Gadkari, Varun V.; Ruotolo, Brandon T.; Holehouse, Alex S.; Salmon, Loic; Showalter, Scott A.; Bardwell, James C. A.
  作者单位：University of Michigan System; University of Michigan; Howard Hughes Medical Institute; University of Michigan System; University of Michigan; Washington University (WUSTL); Washington University (WUSTL); Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California San Francisco; University of Minnesota System; University of Minnesota Twin Cities; University of California System; University of California San Francisco
  摘要：Intrinsically disordered protein regions (IDRs) are well established as contributors to intermolecular interactions and the formation of biomolecular condensates. In particular, RNA- binding proteins (RBPs) often harbor IDRs in addition to folded RNA- binding domains that contribute to RBP function. To understand the dynamic interactions of an IDR-RNA complex, we characterized the RNA- binding features of a small (68 residues), positively charged IDR- containing protein, Small ERDK-Rich Factor...
• Synthesizing ordered polar patterns in nonpolar SrTiO3 nanofilms via wrinkle- induced flexoelectricity AI翻译
  作者：Shang, Hongxing; Sheng, Tang; Dong, Huiting; Wu, Yihan; Ma, Qianqian; Zhang, Xin; Lv, Lingtong; Cao, Hongyu; Deng, Feng; Liang, Xu; Hu, Shuling; Shen, Shengping
  作者单位：Xi'an Jiaotong University; Fuzhou University
  摘要：Ordered polar structures in oxide nanofilms play a pivotal role in the development of nanoelectronic applications. Hitherto, ordered polar structures have been restricted to a limited number of ferroelectric materials, and there is no effective scheme to induce and manipulate ordered polar patterns in centrosymmetric nonpolar nanofilms due to the absence of spontaneous symmetry breaking. Here, we circumvent these limitations by utilizing the wrinkle- induced strain gradient modulation associat...
• Using the phenotype differences model to identify genetic effects in samples of partially genotyped sibling pairs AI翻译
  作者：Trejo, Sam; Kanopka, Klint
  作者单位：Princeton University; New York University
  摘要：The identification of causal relationships between specific genes and social, behavioral, and health outcomes is challenging due to environmental confounding from population stratification and dynastic genetic effects. Existing methods to eliminate environmental confounding leverage random genetic variation resulting from recombination and require within-family dyadic genetic data (i.e., parent-child and/or sibling pairs), meaning they can only be applied in relatively small and selected sampl...