49期

最新文章

• Recurrent DNA nicks drive massive expansions of (GAA)n repeats AI翻译
  作者：Li, Liangzi; Scott, W. Shem; Khristich, Alexandra N.; Armenia, Jillian F.; Mirkin, Sergei M.
  作者单位：Tufts University; Stanford University; Vanderbilt University
  摘要：Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA)n repeat expansions are responsible for Friedreich's ataxia as well as late- onset cerebellar ataxias (LOCAs). Thus, the mechanisms of (GAA)n repeat expansions attract broad scientific attention. To investigate the role of DNA nicks in this process, we utilized a CRISPR-Cas9 nickase system to introduce targeted nicks adjacent to the (GAA)n repeat tract. We found that DNA nicks 5 ' of the...
• Molecular architecture of synaptic vesicles AI翻译
  作者：Kravcenko, Uljana; Ruwolt, Max; Kroll, Jana; Yushkevich, Artsemi; Zenkner, Martina; Ruta, Julia; Lotfy, Rowaa; Wanker, Erich E.; Rosenmund, Christian; Liu, Fan; Kudryashev, Mikhail
  作者单位：Helmholtz Association; Max Delbruck Center for Molecular Medicine; Humboldt University of Berlin; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Helmholtz Association; Max Delbruck Center for Molecular Medicine; Free University of Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：Synaptic vesicles (SVs) store and transport neurotransmitters to the presynaptic active zone for release by exocytosis. After release, SV proteins and excess membrane are recycled via endocytosis, and new SVs can be formed in a clathrin- dependent manner. This process maintains complex molecular composition of SVs through multiple recycling rounds. Previous studies explored the molecular composition of SVs through proteomic analysis and fluorescent microscopy, proposing a model for an average ...
• Impression management in research reporting: When effects are not really as pronounced as claimed AI翻译
  作者：Rippon, Gina
  作者单位：Aston University
• Nebulized vasopressin penetrates CSF and improves social cognition without inducing aggression in a rhesus monkey model of autism AI翻译
  作者：Talbot, Catherine F.; Oztan, Ozge; Simmons, Sierra M. V.; Trainor, Callum; Ceniceros, Lesly C.; Nguyen, Duyen K. K.; Del Rosso, Laura A.; Garner, Joseph P.; Capitanio, John P.; Parker, Karen J.
  作者单位：Florida Institute of Technology; Stanford University; University of California System; University of California Davis; Stanford University
  摘要：Low cerebrospinal (CSF) arginine vasopressin (AVP) concentration is a biomarker of social impairment in low- social monkeys and children with autism, suggesting that AVP administration may improve primate social functioning. However, AVP administration also increases aggression, at least in neurotypical animals with intact AVP signaling. Here, we tested the effects of a voluntary drug administration method in low- social male rhesus monkeys with high autistic- like trait burden. Monkeys receiv...
• Universal moiré buckling of freestanding 2D bilayers AI翻译
  作者：Wang, Jin; Tosatti, Erio
  作者单位：International School for Advanced Studies (SISSA); Abdus Salam International Centre for Theoretical Physics (ICTP)
  摘要：The physics of membranes, a classic subject, acquires new momentum from twodimensional (2D) materials multilayers. This work reports the surprising results emerged during a theoretical study of equilibrium geometry of bilayers as freestanding membranes. While ordinary membranes are prone to buckle around compressive impurities, we predict that all 2D material freestanding bilayers universally undergo, even if impurity-free, a spontaneous out-of-plane buckling. The moir & eacute; network nodes ...
• MR1 presents vitamin B6-related compounds for recognition by MR1-reactive T cells AI翻译
  作者：Mcinerney, Mitchell P.; Awad, Wael; Souter, Michael N. T.; Kang, Yang; Wang, Carl J. H.; Poa, Kean Chan Yew; Abdelaal, Mohamed R.; Le, Ngoc H.; Shepherd, Chloe M.; Mcneice, Conor; Meehan, Lucy J.; Nelson, Adam G.; Raynes, Jeremy M.; Mak, Jeffrey Y. W.; Mccluskey, James; Chen, Zhenjun; Ang, Ching-Seng; Fairlie, David P.; Le Nours, Jerome; Illing, Patricia T.; Rossjohn, Jamie; Purcell, Anthony W.
  作者单位：Monash University; Monash University; University of Melbourne; Peter Doherty Institute; University of Queensland; University of Queensland; University of Melbourne; Cardiff University
  摘要：The major histocompatibility complex class I related protein (MR1) presents microbially derived vitamin B2 precursors to mucosal- associated invariant T (MAIT) cells. MR1 can also present other metabolites to activate MR1- restricted T cells expressing more diverse T cell receptors (TCRs), some with anti- tumor reactivity. However, knowledge of the range of the antigen(s) that can activate diverse MR1- reactive T cells remains incomplete. Here, we identify pyridoxal (vitamin B6) as a naturally...
• The HUSH epigenetic repressor complex silences PML nuclear body- associated HSV-1 quiescent genomes AI翻译
  作者：Roubille, Simon; Escure, Tristan; Juillard, Franceline; Corpet, Armelle; Neplaz, Remi; Binda, Olivier; Seurre, Coline; Gonin, Mathilde; Bloor, Stuart; Cohen, Camille; Texier, Pascale; Haigh, Oscar; Pascual, Olivier; Ganor, Yonatan; Magdinier, Frederique; Labetoulle, Marc; Lehner, Paul J.; Lomonte, Patrick
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Institut Universitaire de France; University of Ottawa; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Paris Saclay; Universite Claude Bernard Lyon 1; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Hopital Universitaire Antoine-Beclere - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay
  摘要：Herpes simplex virus 1 (HSV-1) latently infected neurons display diverse patterns in the distribution of the viral genomes within the nucleus. A key pattern involves quiescent HSV-1 genomes sequestered in promyelocytic leukemia nuclear bodies (PML NBs) forming viral DNA- containing PML-NBs (vDCP NBs). Using a cellular model that replicates vDCP NB formation, we previously demonstrated that these viral genomes are chromatinized with the H3.3 histone variant modified on its lysine 9 by trimethyl...
• Lethal COVID-19 associates with RAAS- induced inflammation for multiple organ damage including mediastinal lymph nodes AI翻译
  作者：Topper, Michael J.; Guarnieri, Joseph W.; Haltom, Jeffrey A.; Chadburn, Amy; Cope, Henry; Frere, Justin; An, Julia; Borczuk, Alain; Sinha, Saloni; Kim, Jangkeun; Park, Jiwoon; Butler, Daniel; Meydan, Cem; Foox, Jonathan; Bram, Yaron; Richard, Stephanie A.; Epsi, Nusrat J.; Agan, Brian; Chenoweth, Josh G.; Simons, Mark P.; Tribble, David; Burgess, Timothy; Dalgard, Clifton; Heise, Mark T.; Moorman, Nathaniel J.; Baxter, Victoria K.; Madden, Emily A.; Taft-Benz, Sharon A.; Anderson, Elizabeth J.; Sanders, Wes A.; Dickmander, Rebekah J.; Beigel, Katherine; Widjaja, Gabrielle A.; Janssen, Kevin A.; Lie, Timothy; Murdock, Deborah G.; Angelin, Alessia; Albrecht, Yentli E. Soto; Olali, Arnold Z.; Cen, Zimu; Dybas, Joseph; Priebe, Waldemar; Emmett, Mark R.; Best, Sonja M.; Johnson, Maya Kelsey; Trovao, Nidia S.; Clark, Kevin B.; Zaksas, Victoria; Meller, Robert; Grabham, Peter; Schisler, Jonathan C.; Moraes-Vieira, Pedro M.; Pollett, Simon; Mason, Christopher E.; Wurtele, Eve Syrkin; Taylor, Deanne; Schwartz, Robert E.; Beheshti, Afshin; Wallace, Douglas C.; Baylin, Stephen B.
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; Cornell University; Weill Cornell Medicine; University of Nottingham; Icahn School of Medicine at Mount Sinai; Cornell University; Weill Cornell Medicine; Uniformed Services University of the Health Sciences - USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; Uniformed Services University of the Health Sciences - USA; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Texas System; University of Texas Medical Branch Galveston; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH Fogarty International Center (FIC); Carnegie Mellon University; University of Chicago; Morehouse School of Medicine; Columbia University; Universidade Estadual de Campinas; Universidade de Sao Paulo; Iowa State University; Iowa State University; Iowa State University; University of Pennsylvania; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pennsylvania; Van Andel Institute
  摘要：Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS- CoV-2. Subsets of the 100 top- upregulated genes in nasal swabs are upregulated in the heart, lung, kidney, and liver, but not mediastinal lymph nodes. Twenty- two of these are noncanonical immune genes, which we link to components of the renin- angiotensin- activation- system that manifest as increased fibrin deposition, ...
• Intercellular friction and motility drive orientational order in cell monolayers, (vol 121, e2319310121, 2024) AI翻译
  作者：Chiang, Michael; Hopkins, Austin; Loewe, Benjamin; Marchetti, M. Cristina; Marenduzzo, Davide
• Hominin brain size increase has emerged from within-species encephalization AI翻译
  作者：Pueschel, Thomas A.; Nicholson, Samuel L.; Baker, Joanna; Barton, Robert A.; Venditti, Chris
  作者单位：University of Oxford; University of Reading; Max Planck Society; Durham University
  摘要：The fact that rapid brain size increase was clearly a key aspect of human evolution has prompted many studies focusing on this phenomenon, and many suggestions as to the underlying evolutionary patterns and processes. No study to date has however separated out the contributions of change through time within vs. between hominin species while simultaneously incorporating effects of body size. Using a phylogenetic approach never applied before to paleoanthropological data, we show that relative b...