49期

最新文章

• Cognitive reflection is a distinct and measurable trait AI翻译
  作者：Meyer, Andrew; Attali, Yigal; Bar-Hillel, Maya; Frederick, Shane; Kahneman, Daniel
  作者单位：Chinese University of Hong Kong; Hebrew University of Jerusalem; Yale University; Princeton University
  摘要：We report the findings of an adversarial collaboration examining whether the cognitive reflection test (CRT) measures anything beyond mathematical aptitude and, if so, whether its incremental predictive validity can be attributed to reflection, per se. We found that an 8-item CRT has greater predictive validity than an 8-item Mathematical Aptitude Test (MAT) consisting of comparably difficult items which lack dominant intuitive lures. Further, the incremental predictive validity stems from the...
• Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member AI翻译
  作者：Padhi, Chandrashekhar; Field, Christopher M.; Forneris, Clarissa C.; Olszewski, Dominik; Fraley, Amy E.; Sandu, Ioana; Scott, Thomas A.; Farnung, Jakob; Ruscheweyh, Hans - Joachim; Panda, Ananta Narayan; Oxenius, Annette; Greber, Urs F.; Bode, Jeffrey W.; Sunagawa, Shinichi; Raina, Vishakha; Suar, Mrutyunjay; Piel, Joern
  作者单位：University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Kalinga Institute of Industrial Technology (KIIT)
  摘要：In contrast to the large body of work on bioactive natural products from individually cultivated bacteria, the chemistry of environmental microbial communities remains largely elusive. Here, we present a comprehensive bioinformatic and functional study on a complex and interaction-rich ecosystem, algal-bacterial (microbial) mats of Lake Chilika in India, Asia's largest brackish water body. We report the bacterial compositional dynamics over the mat life cycle, >1,300 reconstructed environmenta...
• PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity AI翻译
  作者：Varuzhanyan, Grigor; Chen, Chia-Chun; Freeland, Jack; He, Tian; Tran, Wendy; Song, Kai; Wang, Liang; Cheng, Donghui; Xu, Shili; Dibernardo, Gabriella A.; Esedebe, Favour N.; Bhatia, Vipul; Han, Mingqi; Abt, Evan R.; Park, Jung Wook; Memarzadeh, Sanaz; Shackelford, David B.; Lee, John K.; Graeber, Thomas G.; Shirihai, Orian S.; Witte, Owen N.
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; Fred Hutchinson Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Duke University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare System; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Ben-Gurion University of the Negev; University of California System; University of California Los Angeles
  摘要：Adenocarcinomas from multiple tissues can converge to treatment- resistant small cell neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 subtypes. We investigated how mitochondrial metabolism influences SCN cancer (SCNC) progression. Extensive bioinformatics analyses encompassing thousands of patient tumors and human cancer cell lines uncovered enhanced expression of proliferator- activatedreceptor gamma coactivator 1- alpha (PGC-1 alpha), a potent regulator of mitochond...
• Constitutive opening of the Kv7.2 pore activation gate causes KCNQ2- developmental encephalopathy AI翻译
  作者：Nappi, Mario; Alberini, Giulio; Berselli, Alessandro; Roscioni, Agnese; Soldovieri, Maria Virginia; Servettini, Ilenio; Barrese, Vincenzo; Weckhuysen, Sarah; Chiu, Ting-Gee Annie; Scheffer, Ingrid E.; Benfenati, Fabio; Maragliano, Luca; Miceli, Francesco; Taglialatela, Maurizio
  作者单位：University of Naples Federico II; Istituto Italiano di Tecnologia - IIT; Marche Polytechnic University; University of Molise; Flanders Institute for Biotechnology (VIB); University of Antwerp; University of Antwerp; University of Antwerp; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; University of Melbourne; University of Melbourne; Florey Institute of Neuroscience & Mental Health; University of Melbourne; Murdoch Children's Research Institute; Royal Children's Hospital Melbourne
  摘要：Pathogenic variants in KCNQ2 encoding Kv7.2 voltage- gated potassium channel subunits cause developmental encephalopathies ( KCNQ2- encephalopathies), both with and without epilepsy. We herein describe the clinical, in vitro, and in silico features of two encephalopathy- causing variants (A317T, L318V) in Kv7.2 affecting two consecutive residues in the S6 activation gate that undergoes large structural rearrangements during pore opening; the disease- causing A356T variant in KCNQ3, paralogous ...
• Profile of Susan Goldin-Meadow AI翻译
  作者：Ravindran, Sandeep
• Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration AI翻译
  作者：Zhu, Dong; Liu, Shu-Yue; Sun, Ming-Ming; Yi, Xing-Yun; Duan, Gui-Lan; Ye, Mao; Gillings, Michael R.; Zhu, Yong-Guan
  作者单位：Chinese Academy of Sciences; Institute of Urban Environment, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS; Nanjing Agricultural University; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Macquarie University
  摘要：Habitats with intermittent flooding, such as paddy soils, are crucial reservoirs in the global carbon pool; however, the effect of phage-host interactions on the biogeochemical cycling of carbon in paddy soils remains unclear. Hence, this study applied multiomics and global datasets integrated with validation experiments to investigate phage-host community interactions and the potential of phages to impact carbon sequestration in paddy soils. The results demonstrated that paddy soil phages har...
• Compartmentalized pooling generates orientation selectivity in wide- field amacrine cells AI翻译
  作者：Lei, Wanyu; Clark, Damon A.; Demb, Jonathan B.
  作者单位：Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University; Yale University
  摘要：Orientation is one of the most salient features in visual scenes. Neurons at multiple levels of the visual system detect orientation, but in many cases, the underlying biophysical mechanisms remain unresolved. Here, we studied mechanisms for orientation detection at the earliest stage in the visual system, in B/Kwide-field amacrine cells (B/KWACs), a group of giant, nonspiking interneurons in the mouse retina that coexpress Bhlhe22 (B) and Kappa Opioid Receptor (K). B/K WACs exhibit orientatio...
• Inhibition of zDHHC7-driven protein S- palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease AI翻译
  作者：Natale, Francesca; Spinelli, Matteo; Rinaudo, Marco; Gulisano, Walter; Sarrapochiello, Ida Nifo; Aceto, Giuseppe; Puzzo, Daniela; Fusco, Salvatore; Grassi, Claudio
  作者单位：Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; University of Catania; IRCCS - Oasi Research Institute
  摘要：Protein post- translational modifications (PTM) play a crucial role in the modulation of synaptic function and their alterations are involved in the onset and progression of neurodegenerative disorders. S- palmitoylation is a PTM catalyzed by zinc finger DHHC domain containing (zDHHC) S- acyltransferases that affects both localization and activity of proteins regulating synaptic plasticity and amyloid-f3 (Af3) metabolism. Here, we found significant increases of both zDHHC7 expression and prote...
• Reply to Fine et al. and Rippon: Significant sex differences in accelerated cortical thinning associated with the COVID-19 lockdowns AI翻译
  作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
• The global spread of Oriental Horses in the past 1,500 years through the lens of the Y chromosome AI翻译
  作者：Radovic, Lara; Remer, Viktoria; Rigler, Doris; Bozlak, Elif; Allen, Lucy; Brem, Gottfried; Reissman, Monika; Brockmann, Gudrun A.; Ropka-Molik, Katarzyna; Stefaniuk-Szmukier, Monika; Kalinkova, Liliya; Kalashnikov, Valery V.; Zaitev, Alexander M.; Raudsepp, Terje; Castaneda, Caitlin; von Butler-Wemken, Ines; Rosa, Laura Patterson; Brooks, Samantha A.; Novoa-Bravo, Miguel; Kostaras, Nikos; Abdurasulov, Abdugani; Antczak, Douglas F.; Miller, Donald C.; Lopes, Maria Susana; Machado, Artur da Camara; Lindgren, Gabriella; Juras, Rytis; Cothran, Gus; Wallner, Barbara
  作者单位：University of Veterinary Medicine Vienna; University of Veterinary Medicine Vienna; Humboldt University of Berlin; National Research Institute of Animal Production; Texas A&M University System; Texas A&M University College Station; Long Island University; Long Island University Post; State University System of Florida; University of Florida; Osh State University; Cornell University; Universidade dos Acores; Swedish University of Agricultural Sciences
  摘要：Since their domestication, horses have accompanied mankind, and humans have constantly shaped horses according to their needs through stallion- centered breeding. Consequently, the male- specific portion of the Y chromosome (MSY) is extremely uniform in modern horse breeds. The majority of stallions worldwide carry MSY haplotypes inance of the Crown in modern horse breeds is thought to represent a footprint of the vast impact of stallions of Oriental origin in the past millennium. Here, we rep...