6期

最新文章

• Underlying and proximate drivers of biodiversity changes in Mesoamerican biosphere reserves AI翻译
  作者：Auliz-Ortiz, Daniel Martin; Benitez-Malvido, Julieta; Arroyo- Rodriguez, Victor; Dirzo, Rodolfo; Perez-Farrera, Miguel Angel; Luna-Reyes, Roberto; Mendoza, Eduardo; Alvarez-Anorve, Mariana Yolotl; Alvarez-Sanchez, Javier; Arias-Ataide, Dulce Maria; Avila-Cabadilla, Luis Daniel; Botello, Francisco; Braasch, Marco; Casas, Alejandro; Campos-Villanueva, Delfino Alvaro; Cedeno-Vazquez, Jose Rogelio; Chavez-Tovar, Jose Cuauhtemoc; Coates, Rosamond; Dechnik-Vazquez, Yanus; Arizmendi, Maria del Coro; Dias, Pedro Americo; Dorado, Oscar; Enriquez, Paula; Escalona-Seguras, Griselda; Farias-Gonzalez, Veronica; Favilat, Mario E.; Garcia, Andres; Garcia-Moralesv, Leccinum Jesus; Gavito-Perez, Fernando; Gomez-Domingueze, Hector; Gonzalez-Garcia, Fernando; Gonzalez-Zamora, Arturo; Cuevas-Guzman, Ramon; Haro-Belchez, Enrique; Hernandez-Huerta, Arturo Heriberto; Hernandez-Ordonez, Omar; Horvat, Anna; Ibarra-Manriquez, Guillermo; Lavin-Murcio, Pablo Antonio; Lira-Saade, Rafael; Lopez-Diaze, Karime; Macswiney, G. M. Cristina; Mandujano, Salvador; Martinez-Camilo, Ruben; Martinez-Avaloshh, Jose Guadalupe; Martinez-Melendezii, Nayely; Monroy-Ojeda, Alan; Mora, Francisco; Mora-Olivo, Arturo; Muench, Carlos; Pena-Mondragon, Juan L.; Percino-Daniel, Ruth; Ramirez-Marcial, Neptali; Reyna-Hurtado, Rafael; Rodriguez-Ruiz, Erick Ruben; Sanchez-Cordero, Victor; Suazo-Ortuno, Ireri; Teran-Juarez, Sergio Alejandro; Valdivieso-Perez, Ingrid Abril; Valencia, Vivian; Valenzuela-Galvan, David; Vargas-Contreras, Jorge Albino; Vazquez-Perez, Jose Raul; Vega-Rivera, Jorge Humberto; Venegas-Barrera, Crystian Sadiel; Martinez-Ramosa, Miguel
  作者单位：Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Stanford University; Stanford University; Universidad Michoacana de San Nicolas de Hidalgo; Universidad Nacional Autonoma de Mexico; Universidad Autonoma del Estado de Morelos; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; El Colegio de la Frontera Sur (ECOSUR); Universidad Autonoma Metropolitana - Mexico; Universidad Nacional Autonoma de Mexico; Universidad Veracruzana; El Colegio de la Frontera Sur (ECOSUR); El Colegio de la Frontera Sur (ECOSUR); Instituto de Ecologia - Mexico; Universidad Nacional Autonoma de Mexico; Instituto de Ecologia - Mexico; Universidad Veracruzana; Universidad de Guadalajara; Instituto de Ecologia - Mexico; Universidad Autonoma de Ciudad Juarez; Universidad Autonoma del Estado de Morelos; Universidad Veracruzana; Universidad Autonoma de Tamaulipas; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Bishops University; Universidad Autonoma del Estado de Morelos
  摘要：Protected areas are of paramount relevance to conserving wildlife and ecosystem contributions to people. Yet, their conservation success is increasingly threatened by human activities including habitat loss, climate change, pollution, and species overexploitation. Thus, understanding the underlying and proximate drivers of anthropogenic threats is urgently needed to improve protected areas' effectiveness, especially in the biodiversity-rich tropics. We addressed this issue by analyzing expert-...
• Aqueous chemimemristor based on proton- permeable graphene membranes AI翻译
  作者：Wang, Yongkang; Seki, Takakazu; Gkoupidenis, Paschalis; Chen, Yunfei; Nagata, Yuki; Bonn, Mischa
  作者单位：Southeast University - China; Max Planck Society
  摘要：Memristive devices, electrical elements whose resistance depends on the history of applied electrical signals, are leading candidates for future data storage and neuromorphic computing. Memristive devices typically rely on solid - state technology, while aqueous memristive devices are crucial for biology- related applications such as next- generation brain- machine interfaces. Here, we report a simple graphene-based aqueous memristive device with long - term and tunable memory regulated by rev...
• SonoTransformers: Transformable acoustically activated wireless microscale machines AI翻译
  作者：Zhang, Zhiyuan; Shi, Zhan; Ahmed, Daniel; Zhang, Yihui
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Shape transformation, a key mechanism for organismal survival and adaptation, has gained importance in developing synthetic shape- shifting systems with diverse applications ranging from robotics to bioengineering. However, designing and controlling microscale shape- shifting materials remains a fundamental challenge in various actuation modalities. As materials and structures are scaled down to the microscale, they often exhibit size- dependent characteristics, and the underlying physical mec...
• Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains AI翻译
  作者：Nonaka, Hiroshi; Sakamoto, Seiji; Shiraiwa, Kazuki; Ishikawa, Mamoru; Tamura, Tomonori; Okuno, Kyohei; Kondo, Takumi; Kiyonaka, Shigeki; Susaki, Etsuo A.; Shimizu, Chika; Ueda, Hiroki R.; Kakegawa, Wataru; Arai, Itaru; Yuzaki, Michisuke; Hamachi, Itaru
  作者单位：Kyoto University; Japan Science & Technology Agency (JST); Nagoya University; Juntendo University; RIKEN; University of Tokyo; Keio University
  摘要：Neurotransmitter receptors are essential components of synapses for communication between neurons in the brain. Because the spatiotemporal expression profiles and dynamics of neurotransmitter receptors involved in many functions are delicately governed in the brain, in vivo research tools with high spatiotemporal resolution for receptors in intact brains are highly desirable. Covalent labeling by chemical reaction (chemical labeling) of proteins without genetic manipulation is now a powerful m...
• Malignant tumor cells engender second membrane-lined organelles for self- protection and tumor progression AI翻译
  作者：Yi, Tingfang; Wagner, Gerhard
  作者单位：Harvard University; Harvard Medical School
  摘要：Cancer is a leading cause of mortality in humans, but the efficacy of current treatments for many cancers is limited, as they lack unique mechanistically defined targets. Here, we show that, upon malignant transformation, aggressive oncocells generate a second membrane exterior to their plasma membrane to form cytocapsulas (CCs) and cytocapsular tubes (CCTs), which all together constitute cytocapsular oncocells with pleotropic biological functions in cancer patient tissues in vivo. Proteomic a...
• Single- cell analysis of refractory anti- SRP necrotizing myopathy treated with anti- BCMA CAR- T cell therapy AI翻译
  作者：Qin, Chuan; Dong, Ming-Hao; Zhou, Luo-Qi; Wang, Wen; Cai, Song-Bai; You, Yun-Fan; Shang, Ke; Xiao, Jun; Wang, Di; Li, Chun-Rui; Zhang, Min; Bu, Bi-Tao; Tian, Dai-Shi; Wang, Wei
  作者单位：Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology
  摘要：Immune- mediated necrotizing myopathy (IMNM) is an autoimmune disorder associated with the presence of autoantibodies, characterized by severe clinical presentation with rapidly progressive muscular weakness and elevated levels of creatine kinase, while traditional pharmacological approaches possess varying and often limited effects. Considering the pathogenic role of autoantibodies, chimeric antigen receptor (CAR) - T cells targeting B cell maturation antigen (BCMA) have emerged as a promisin...
• Marsquakes shake up views of the Red Planet's deep interior AI翻译
  作者：Croswell, Ken
• Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I AI翻译
  作者：Sun, Xin; Watanabe, Toshiyuki; Oda, Yoshitaka; Shen, Weidong; Ahmad, Alaa; Ouda, Ryota; de Figueiredo, Paul; Kitamura, Hidemitsu; Tanaka, Shinya; Kobayashi, Koichi S.
  作者单位：Hokkaido University; Hokkaido University; Hokkaido University; Texas A&M University System; Texas A&M University College Station; Texas A&M Health Science Center; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; Toyo University; Hokkaido University; Hokkaido University
  摘要：Impaired expression of MHC (major histocompatibility complex) class I in cancers constitutes a major mechanism of immune evasion. It has been well documented that the low level of MHC class I is associated with poor prognosis and resistance to checkpoint blockade therapies. However, there is lmited approaches to specifically induce MHC class I to date. Here, we show an approach for robust and specific induction of MHC class I by targeting an MHC class I transactivator (CITA)/NLRC5, using a CRI...
• A novel cysteine-rich adaptor protein is required for mucin packaging and secretory granule stability in vivo AI翻译
  作者：Zhang, Liping; Muirhead, Kayla J.; Syed, Zulfeqhar A.; Dimitriadis, Emilios K.; Hagen, Kelly G. Ten
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
  摘要：Mucins are large, highly glycosylated extracellular matrix proteins that line and protect epithelia of the respiratory, digestive, and urogenital tracts. Previous work has shown that mucins form large, interconnected polymeric networks that mediate their biological functions once secreted. However, how these large matrix molecules are compacted and packaged into much smaller secretory granules within cells prior to secretion is largely unknown. Here, we demonstrate that a small cysteine-rich a...